Paracrine effects of hepatocyte growth factor/scatter factor on non-small-cell lung carcinoma cell lines

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1991 • 2,230 citations

Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth.

1992 • 1,345 citations

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

1987 • 1,333 citations

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

1994 • 983 citations

Scatter factor induces blood vessel formation in vivo.

1993 • 704 citations

Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells.

1990 • 695 citations

Emerging Multipotent Aspects of Hepatocyte Growth Factor

1996 • 662 citations

Evidence for the identity of human scatter factor and human hepatocyte growth factor.

1991 • 651 citations

Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.

1992 • 571 citations

Purification and subunit structure of hepatocyte growth factor from rat platelets

1987 • 557 citations

Mechanism of met oncogene activation

1986 • 551 citations

Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors

1991 • 491 citations

Expression of the Met/HGF receptor in normal and neoplastic human tissues.

1991 • 481 citations

Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII

1993 • 373 citations

Clinical significance of ras oncogene activation in human lung cancer

1993 • 361 citations

Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells.

1994 • 320 citations

Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells.

1995 • 301 citations

NCI-navy medical oncology branch cell line data base

1996 • 297 citations

Scatter factor and the c-met receptor: a paradigm for mesenchymal/epithelial interaction.

1994 • 279 citations

Growth of cell lines and clinical specimens of human non-small cell lung cancer in a serum-free defined medium

1987 • 263 citations

The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase.

1991 • 259 citations

Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells.

1992 • 256 citations

Hepatocyte growth factor/hepatopoietin A stimulates the growth of rat kidney proximal tubule epithelial cells (RPTE), rat nonparenchymal liver cells, human melanoma cells, mouse keratinocytes and stimulates anchorage-independent growth of SV-40 transformed RPTE

1991 • 253 citations

Hepatocyte Growth Factor-induced Scatter of Madin-Darby Canine Kidney Cells Requires Phosphatidylinositol 3-Kinase

1995 • 239 citations

Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor).

1994 • 220 citations

Marked stimulation of growth and motility of human keratinocytes by hepatocyte growth factor

1991 • 217 citations

Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger

1993 • 206 citations

Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas

1996 • 193 citations

Met and hepatocyte growth factor/scatter factor signal transduction in normal melanocytes and melanoma cells.

1992 • 185 citations

The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein.

1995 • 180 citations

Regulation of cell growth and motility by hepatocyte growth factor and receptor expression in various cell species

1992 • 171 citations

HGF/SF: a potent cytokine for mammary growth, morphogenesis and development

1995 • 171 citations

Sulfated Oligosaccharides Promote Hepatocyte Growth Factor Association and Govern Its Mitogenic Activity

1995 • 170 citations

ras gene mutations as a prognostic marker in adenocarcinoma of the human lung without lymph node metastasis.

1992 • 168 citations

Association of immunoreactive hepatocyte growth factor with poor survival in resectable non-small cell lung cancer.

1997 • 167 citations

Expression of the proto-oncogenes c-met and c-kit and their ligands, hepatocyte growth factor/scatter factor and stem cell factor, in SCLC cell lines and xenografts

1993 • 164 citations

Specific Uncoupling of GRB2 from the Met Receptor

1996 • 156 citations

Tyrosine 1356 in the carboxyl-terminal tail of the HGF/SF receptor is essential for the transduction of signals for cell motility and morphogenesis.

1994 • 130 citations

Hepatocyte growth factor induces proliferation and morphogenesis in nonparenchymal epithelial liver cells

1993 • 113 citations

Hepatocyte growth factor/scatter factor is an autocrine factor for human normal bronchial epithelial and lung carcinoma cells.

1993 • 111 citations

Hepatocyte Growth Factor and c-Met/Hepatocyte Growth Factor Receptor in Pulmonary Adenocarcinomas: An Evaluation of Their Expression as Prognostic Markers

1996 • 98 citations

IMMUNOREACTIVITY FOR HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR AND ITS RECEPTOR, met, IN HUMAN LUNG CARCINOMAS AND MALIGNANT MESOTHELIOMAS

1996 • 78 citations

Stimulatory effects of hepatocyte growth factor on normal and neoplastic human bronchial epithelial cells

1995 • 78 citations

Branching Tubulogenesis but Not Scatter of Madin-Darby Canine Kidney Cells Requires a Functional Grb2 Binding Site in the Met Receptor Tyrosine Kinase

1996 • 77 citations

Receptor chimeras indicate that the met tyrosine kinase mediates the motility and morphogenic responses of hepatocyte growth/scatter factor.

1994 • 64 citations

Tyrosine Phosphorylation of Phospholipase Cγ in c-met/HGF Receptor-Stimulated Hepatocytes: Comparison with HepG2 Hepatocarcinoma Cells

1993 • 55 citations

Angiogenesis correlates with vascular endothelial growth factor expression but not with Ki-ras oncogene activation in non-small cell lung carcinoma.

1997 • 47 citations

Effect of hepatocyte growth factor on the expression of E- and P-cadherin in gastric carcinoma cell lines

1994 • 46 citations

Characterization of biliary epithelial cells isolated from needle biopsies of human liver in the presence of hepatocyte growth factor.

1995 • 39 citations

Proto-oncogene and growth factor/receptor expression in the establishment of primary human non-small cell lung carcinoma cell lines.

1993 • 35 citations

Hepatocyte growth factor/scatter factor-Met signaling induces proliferation, migration, and morphogenesis of pancreatic oval cells.

1996 • 33 citations

Human Lung Cancer Cell Line Producing Hepatocyte Growth Factor/Scatter Factor

1992 • 29 citations

Dissociation of C‐fos Induction and Mitogen‐Activated‐Protein Kinase Activation from the Hepatocyte‐Growth‐Factor‐Induced Motility Response in Human Gastric Carcinoma Cells

1996 • 17 citations

Activation of Overexpressed Receptors for Insulin and Epidermal Growth Factor Interferes in Mitogenic Signaling without Affecting the Activation of p21ras

1994 • 8 citations

Hepatocyte growth factor induces proliferation and morphogenesis in nonparenchymal epithelial liver cells

1993 • 8 citations

Expression of the proto-oncogenes c-met and c-kit and their ligands, hepatocyte growth factor/scatter factor and stem cell factor, in SCLC cell lines and xenografts

1993 • 3 citations