Encapsulated Islets in Diabetes Treatment

Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

2000 • 5,125 citations

Microencapsulated Islets as Bioartificial Endocrine Pancreas

1980 • 2,325 citations

Differentiation of Embryonic Stem Cells to Insulin-Secreting Structures Similar to Pancreatic Islets

2001 • 1,468 citations

Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells

2000 • 695 citations

Insulin independence in a type 1 diabetic patient after encapsulated islet transplantation

1994 • 650 citations

Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue

2000 • 435 citations

Maintenance of Normoglycemia in Diabetic Mice by Subcutaneous Xenografts of Encapsulated Islets

1991 • 344 citations

Pancreatic stem cells

2002 • 292 citations

Complete Protection of Islets Against Allorejection and Autoimmunity by a Simple Barium-Alginate Membrane

2001 • 285 citations

Prolonged survival of transplanted islets of Langerhans encapsulated in a biocompatible membrane

1984 • 253 citations

SUCCESSFUL REVERSAL OF SPONTANEOUS DIABETES IN DOGS BY INTRAPERITONEAL MICROENCAPSULATED ISLETS

1992 • 204 citations

Xenotransplantation of canine, bovine, and porcine islets in diabetic rats without immunosuppression.

1991 • 149 citations

The effects of alginate composition on encapsulated βTC3 cells

2001 • 139 citations

Survival and Maturation of Microencapsulated Porcine Neonatal Pancreatic Cell Clusters Transplanted into Immunocompetent Diabetic Mice

2003 • 134 citations

Regulated hepatic insulin gene therapy of STZ-diabetic rats

2000 • 115 citations

Glucose regulated production of human insulin in rat hepatocytes

2000 • 111 citations

Islet cell transplantation

2001 • 85 citations

Auto-regulated Hepatic Insulin Gene Expression in Type 1 Diabetic Rats

2001 • 75 citations

Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity.

2000 • 69 citations

Effects of alginate composition on the metabolic, secretory, and growth characteristics of entrapped βTC3 mouse insulinoma cells

1999 • 65 citations

The Effect of Capsule Composition in the Reversal of Hyperglycemia in Diabetic Mice Transplanted with Microencapsulated Allogeneic Islets

2003 • 50 citations

Xenotransplantation of Pig Islets in Diabetic Dogs with Use of a Microcapsule Composed of Agarose and Polystyrene Sulfonic Acid Mixed Gel

2002 • 47 citations

Development of genetically engineered human intestinal cells for regulated insulin secretion using rAAV-mediated gene transfer

2003 • 38 citations

Normalization of diabetes in cynomolgus monkeys by xenotransplantation of microencapsulated porcine islets.

1994 • 21 citations

Generation of islets of Langerhans from adult pancreatic stem cells

2002 • 20 citations

In Vitro and In Vivo Evaluation of Microencapsulated Porcine Islets

1992 • 18 citations

Transplantation of porcine and bovine islets into mice without immunosuppression using uncoated alginate microspheres.

1995 • 18 citations

Preproinsulin mRNA engineering and its application to the regulation of insulin secretion from human hepatomas

2003 • 17 citations

Effects of Alginate Composition on the Growth and Overall Metabolic Activity of βTC3 Cells

2002 • 14 citations

Xenotransplantation of bovine islets into dogs using biodegradable, injectable microreactors.

1996 • 5 citations