Xenotransplantation of Pig Islets in Diabetic Dogs with Use of a Microcapsule Composed of Agarose and Polystyrene Sulfonic Acid Mixed Gel

Normalization of diabetes in spontaneously diabetic cynomologus monkeys by xenografts of microencapsulated porcine islets without immunosuppression.

1996 • 453 citations

SUCCESSFUL REVERSAL OF SPONTANEOUS DIABETES IN DOGS BY INTRAPERITONEAL MICROENCAPSULATED ISLETS

1992 • 204 citations

Isolation of the elusive pig islet.

1990 • 183 citations

Agarose for a bioartificial pancreas

1992 • 144 citations

Microencapsulated islet grafts in the BB/E rat: a possible role for cytokines in graft failure

1992 • 143 citations

Critical Mass of Purified Islets That Induce Normoglycemia After Implantation Into Dogs

1988 • 135 citations

Treatment of Diabetes by Xenogeneic Islets Without Immunosuppression: Use of a Vascularized Bioartificial Pancreas

1996 • 112 citations

Beneficial Influence of Glycemic Control Upon the Growth and Function of Transplanted Islets

1994 • 111 citations

Complement activation and inflammation triggered by model biomaterial surfaces

1998 • 104 citations

Hyperglycemia-induced B cell toxicity. The fate of pancreatic islets transplanted into diabetic mice is dependent on their genetic background.

1990 • 92 citations

The complement system in xenotransplantation

1992 • 89 citations

Strategy for developing microbeads applicable to islet xenotransplantation into a spotaneous diabetic NOD mouse

1994 • 73 citations

A newly developed three-layer agarose microcapsule for a promising biohybrid artificial pancreas: Rat to mouse xenotransplantation

1996 • 64 citations

INTACT PIG PANCREATIC ISLET FUNCTION IN THE PRESENCE OF HUMAN XENOREACTIVE NATURAL ANTIBODY BINDING AND COMPLEMENT ACTIVATION1

1997 • 51 citations

PORCINE ISLET CELLS OF LANGERHANS ARE DESTROYED BY HUMAN COMPLEMENT AND NOT BY ANTIBODY-DEPENDENT CELL-MEDIATED MECHANISMS1

1996 • 43 citations

Critical mass of purified islets that induce normoglycemia after implantation into dogs

1988 • 39 citations

Treatment of diabetes by xenogeneic islets without immunosuppression. Use of a vascularized bioartificial pancreas

1996 • 35 citations

Total pancreatectomy in dogs

1984 • 33 citations

Control of Complement Activities for Immunoisolation

1999 • 30 citations

Histological Analysis of Microencapsulated Dopamine-Secreting Cells in Agarose/Poly(styrene sulfonic acid) Mixed Gel Xenotransplanted into the Brain

1996 • 30 citations

Beneficial influence of glycemic control upon the growth and function of transplanted islets

1994 • 30 citations

Specific interactions of polystyrene biomaterials with factor D of human complement

1993 • 24 citations

Characterization and transplantation of agarose microencapsulated canine islets of Langerhans.

1997 • 20 citations

Humoral Human Xenoreactivity Against Isolated Pig Pancreatic Islets

2000 • 13 citations

An immuno-isolative membrane capable of consuming cytolytic complement proteins

1997 • 11 citations

Long-term normalization of diabetes by xenotransplantation of newly developed encapsulated pancreatic islets

1998 • 8 citations