Molecular Basis for High Virulence of Hong Kong H5N1 Influenza A Viruses

Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus

1998 • 1,386 citations

Characterization of an Avian Influenza A (H5N1) Virus Isolated from a Child with a Fatal Respiratory Illness

1998 • 1,351 citations

Generation of influenza A viruses entirely from cloned cDNAs

1999 • 1,258 citations

Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system.

1987 • 1,087 citations

A single amino acid in the PB2 gene of influenza A virus is a determinant of host range

1993 • 891 citations

A Mouse Model for the Evaluation of Pathogenesis and Immunity to Influenza A (H5N1) Viruses Isolated from Humans

1999 • 373 citations

Comparisons of Highly Virulent H5N1 Influenza A Viruses Isolated from Humans and Chickens from Hong Kong

1998 • 347 citations

Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and x-ray crystallography

1992 • 339 citations

Influenza virus a pathogenicity: The pivotal role of hemagglutinin

1987 • 276 citations

Biological Heterogeneity, Including Systemic Replication in Mice, of H5N1 Influenza A Virus Isolates from Humans in Hong Kong

1999 • 275 citations

Sequence requirements for cleavage activation of influenza virus hemagglutinin expressed in mammalian cells.

1988 • 253 citations

Role of two of the influenza virus core P proteins in recognizing cap 1 structures (m ⁷ GpppNm) on RNAs and in initiating viral RNA transcription

1981 • 252 citations

Molecular Correlates of Influenza A H5N1 Virus Pathogenesis in Mice

2000 • 195 citations

Direct sequencing of the HA gene of influenza (H3N2) virus in original clinical samples reveals sequence identity with mammalian cell-grown virus

1990 • 176 citations

A single gene determines the host range of influenza virus

1977 • 169 citations

Identification of the cap binding protein of influenza virus

1982 • 150 citations

Reassortant Virus Derived from Avian and Human Influenza A Viruses Is Attenuated and Immunogenic in Monkeys

1982 • 89 citations

The role of the two influenza virus core P proteins in recognizing caplstructure (m^7GpppNm) on RNAs and in initiating viral RNA transcription

1981 • 89 citations

Attenuation of pathogenicity of fowl plague virus by recombination with other influenza A viruses nonpathogenic for fowl: nonexculsive dependence of pathogenicity on hemagglutinin and neuraminidase of the virus

1976 • 85 citations

Use of single-gene reassortant viruses to study the role of avian influenza A virus genes in attenuation of wild-type human influenza A virus for squirrel monkeys and adult human volunteers

1992 • 83 citations