Vaccines prepared with sialyl-Tn and sialyl-Tn trimers using the 4-(4-maleimidomethyl)cyclohexane-1-carboxyl hydrazide linker group result in optimal antibody titers against ovine submaxillary mucin and sialyl-Tn-positive tumor cells

CHROMATOGRAPHlC SEPARATION OF HUMAN BRAIN GANGLIOSIDES*

1963 • 1,644 citations

The Specificity of Serological Reactions

1945 • 1,104 citations

Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex.

1991 • 628 citations

Tumor-Associated Carbohydrate Antigens

1984 • 622 citations

Expression of Tn, sialosyl-Tn, and T antigens in human colon cancer.

1989 • 510 citations

Sialosyl-Tn. A novel mucin antigen associated with prognosis in colorectal cancer patients

1990 • 380 citations

Comparison of O-Linked Carbohydrate Chains in MUC-1 Mucin from Normal Breast Epithelial Cell Lines and Breast Carcinoma Cell Lines:

1996 • 354 citations

Selection of tumor antigens as targets for immune attack using immunohistochemistry: II. Blood group-related antigens

1997 • 292 citations

Efficacy ofHaemophilus IinfluenzaeType b Polysaccharide–Diphtheria Toxoid Conjugate Vaccine in Infancy

1987 • 256 citations

Phase 1 trial of immunological adjuvant QS-21 with a GM2 ganglioside-keyhole limpet haemocyanin conjugate vaccine in patients with malignant melanoma

1994 • 214 citations

GM2-KLH conjugate vaccine: increased immunogenicity in melanoma patients after administration with immunological adjuvant QS-21.

1995 • 207 citations

Antibodies Against Mucin-Associated Sialyl-Tn Epitopes Correlate with Survival of Metastatic Adenocarcinoma Patients Undergoing Active Specific Immunotherapy with Synthetic STn Vaccine

1996 • 184 citations

Immunization of breast cancer patients using a synthetic sialyl-Tn glycoconjugate plus Detox adjuvant

1993 • 183 citations

GD3 vaccines for melanoma: superior immunogenicity of keyhole limpet hemocyanin conjugate vaccines.

1994 • 181 citations

Active specific immunotherapy of a murine mammary adenocarcinoma using a synthetic tumor-associated glycoconjugate.

1990 • 165 citations

Approaches to Augmenting the Immunogenicity of Melanoma Gangliosides: From Whole Melanoma Cells to Ganglioside‐KLH Conjugate Vaccines

1995 • 161 citations

Enhancing the Effect of THERATOPE STn-KLH Cancer Vaccine in Patients with Metastatic Breast Cancer by Pretreatment with Low-Dose Intravenous Cyclophosphamide

1996 • 155 citations

Therapeutic advantage of high-affinity anticarcinoma radioimmunoconjugates.

1992 • 127 citations

Principles and methods for the preparation of drug protein conjugates for immunological studies.

1973 • 125 citations

Carbohydrate antigens as targets for active specific immunotherapy

1996 • 115 citations

Immunogenicity of a Haemophilus influenzae polysaccharide-Neisseria meningitidis outer membrane protein complex conjugate vaccine.

1990 • 110 citations

Epitopic structure of Tn glycophorin A for an anti-Tn antibody (MLS 128).

1993 • 105 citations

Monoclonal antibody-based therapy of a human tumor xenograft with a 177lutetium-labeled immunoconjugate.

1991 • 102 citations

Carbohydrate vaccines that induce antibodies against cancer. 1. Rationale

1997 • 100 citations

A monoclonal antibody that recognizes a cluster of a disaccharide, NeuAc alpha(2—-6)GalNAc, in mucin-type glycoproteins.

1988 • 97 citations

Immune sera and monoclonal antibodies define two configurations for the sialyl Tn tumor antigen.

1995 • 95 citations

Carbohydrate vaccines that induce antibodies against cancer. 2. Previous experience and future plans

1997 • 92 citations

Immune Responses of Mice and Human Breast Cancer Patients following Immunization with Synthetic Sialyl‐Tn Conjugated to KLH Plus Detox Adjuvant

1993 • 83 citations

Phase I trial of iodine-131-chimeric B72.3 (human IgG4) in metastatic colorectal cancer.

1992 • 76 citations

Augmenting the immunogenicity of carbohydrate tumor antigens

1995 • 74 citations

A novel and efficient method for synthetic carbohydrate conjugate vaccine preparation: synthesis of sialyl Tn-KLH conjugate using a 4-(4-N-maleimidomethyl) cyclohexane-1-carboxyl hydrazide (MMCCH) linker arm.

1998 • 70 citations

The influence of epitope density on the immunological properties of hapten-protein conjugates

1974 • 67 citations

Mucin-associated sialosyl-Tn antigen expression in gastric cancer correlates with an adverse outcome

1994 • 66 citations

Immunogenicity of synthetic conjugates of Lewis y oligosaccharide with proteins in mice: towards the design of anticancer vaccines

1998 • 58 citations

Active Specific Immunotherapy Against Adenocarcinomas

1994 • 48 citations

Use of model cell lines to study the biosynthesis and biological role of cancer-associated sialosyl-Tn antigen.

1994 • 41 citations

Tumor-associated glycoprotein-72 serum levels complement carcinoembryonic antigen levels in monitoring patients with gastrointestinal carcinoma. A lingitudinal study

1991 • 39 citations

Analysis of a heterogeneous group of human breast carcinoma associated glycoproteins bearing the Tn determinant

1994 • 25 citations

CONJUGATION PROCEDURES IN ENZYME IMMUNOASSAY

1986 • 3 citations