Endothelin-1 in Human Skin: Immunolocalization, Receptor Binding, mRNA Expression, and Effects on Cutaneous Microvascular Endothelial Cells

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

The Blood Vessels of the Human Skin and Their Responses.

1928 • 882 citations

Relationships between calcium and cyclic nucleotides in cell activation.

1977 • 849 citations

Increased concentrations of nonesterified arachidonic acid, 12L-hydroxy-5,8,10,14-eicosatetraenoic acid, prostaglandin E2, and prostaglandin F2alpha in epidermis of psoriasis.

1975 • 583 citations

Receptor-coupled, Permeabilized Smooth Muscle

1989 • 429 citations

Cellular mechanism of action by a novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells

1988 • 385 citations

Endothelin: visualization of mRNAs by in situ hybridization provides evidence for local action.

1989 • 354 citations

Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in vascular smooth muscle.

1989 • 353 citations

Endothelin 1, an endothelium-derived peptide, is expressed in neurons of the human spinal cord and dorsal root ganglia.

1989 • 349 citations

Cutaneous reactions to intradermal prostaglandins

1971 • 337 citations

Differential role of extra‐ and intracellular calcium in the release of EDRF and prostacyclin from cultured endothelial cells

1988 • 321 citations

Recovery of Prostaglandins in Human Cutaneous Inflammation

1971 • 206 citations

Isolation and Growth of Endothelial Cells from the Microvessels of the Newborn Human Foreskin in Cell Culture

1980 • 177 citations

Stimulation of Phosphatidylinositol Hydrolysis, Diacylglycerol Release, and Gene Expression in Response to Endothelin, a Potent New Agonist for Fibroblasts and Smooth Muscle Cells

1989 • 166 citations

Endothelin-1 stimulates contraction of rat glomerular mesangial cells and potentiates beta-adrenergic-mediated cyclic adenosine monophosphate accumulation.

1990 • 161 citations

Endothelin stimulates phosphatidylinositol hydrolysis and DNA synthesis in brain capillary endothelial cells

1990 • 149 citations

Time course changes in levels of arachidonic acid and prostaglandins D2, E2, F2 alpha in human skin following ultraviolet B irradiation.

1980 • 144 citations

Localization of atrial natriuretic peptide mRNA and immunoreactivity in the rat heart and human atrial appendage.

1987 • 144 citations

Role of Ca2+ and cyclic AMP in the regulation of the production of prostacyclin by the vascular endothelium.

1982 • 140 citations

Effects of endothelin on the mechanical activity and cytosolic calcium levels of various types of smooth muscle

1989 • 133 citations

Cyclic nucleotides and the contraction of smooth muscle.

1975 • 88 citations

The use of 14C-labeled tissue paste standards for the calibration of 125I-labeled ligands in quantitative autoradiography

1987 • 84 citations

Endothelin-1

1989 • 79 citations

Cytosolic calcium regulates phorbol diester binding affinity in intact phagocytes.

1986 • 76 citations

Human Recombinant Interleukin-1α Is Proinflammatory in Normal Human Skin

1988 • 41 citations

Prostacyclin biosynthesis in vascular endothelium is not inhibited by cyclic AMP. Studies with 3-isobutyl-1-methylxanthine and forskolin

1982 • 36 citations

PROSTAGLANDINS AND SMOOTH MUSCLE

1979 • 33 citations

Pro-inflammatory mediators induce sustained release of prostaglandin E2 from human dermal microvascular endothelial cells

1990 • 30 citations

Digital Cutaneous Vascular Responses to Histamine and Neuropeptides in Raynaud's Phenomenon

1991 • 30 citations

Cyclic AMP Enhances Inositol Trisphosphate-Induced Mobilization of Intracellular Ca2+ in Cultured Aortic Smooth Muscle Cells1

1988 • 16 citations

Interleukin‐1 potentiates histamine‐induced release of prostacyclin from human endothelial cells

1990 • 10 citations

The Inflammatory Properties of Eicosanoids in Human Skin

1985 • 3 citations