Pharmacological and biochemical activities of some monomethylxanthine and methyluric acid derivatives of theophylline and caffeine

Adenosine 3‘,5‘-Phosphate in Biological Materials

1962 • 2,102 citations

The Pharmacological Basis of Therapeutics

1976 • 1,403 citations

Multiple cyclic nucleotide phosphodiesterase activities from rat brain

1971 • 1,054 citations

Membrane formation in Tetrahymena pyriformis. 4. Lipid composition and biochemical properties of Tetrahymena pyriformis membrane systems

1971 • 674 citations

Pharmacokinetics of theophylline; Application to adjustment of the clinical dose of aminophylline

1972 • 507 citations

Log-normal distribution of equiefective doses of norepinephrine and acetylcholine in several tissues.

1972 • 430 citations

A STUDY OF THE METABOLISM OF THEOBROMINE, THEOPHYLLINE, AND CAFFEINE IN MAN

1957 • 304 citations

Effect of smoking on theophylline disposition

1976 • 228 citations

Theophylline metabolism by the rat liver microsomal system.

1976 • 155 citations

The tracheal chain; a preparation for the study of antispasmodics with particular reference to bronchodilator drugs.

1947 • 151 citations

Determination of theophylline and its metabolites in human urine and serum by high-pressure liquid chromatography.

1974 • 130 citations

Decreased theophylline half-life in cigarette smokers

1975 • 124 citations

Physiological Disposition of Caffeine

1975 • 117 citations

Force-velocity characteristics of respiratory airway smooth muscle

1969 • 116 citations

METABOLISM OF THEOPHYLLINE (1, 3-DIMETHYLXANTHINE) IN MAN

1952 • 71 citations

Elevation of cyclic amp in C-1300 murine neuroblastoma by adenosine and related compounds and the antagonism of this response by methylxanthines

1977 • 52 citations

A STUDY OF ANTISPASMODIC DRUGS ON THE BRONCHUS

1921 • 48 citations

Studies on the inhibition of phosphodiesterase-catalyzed cyclic AMP and cyclic GMP breakdown and relaxation of canine tracheal smooth muscle

1978 • 41 citations

Metabolism of caffeine-3H in the rat*1, *2

1972 • 38 citations

The effect of methylxanthines on chromosomes of human lymphocytes in culture

1975 • 35 citations

The effects of aminophylline and other xanthines on the pulmonary circulation.

1958 • 29 citations

Further study of some l-substituted theobromine compounds.

1946 • 12 citations

STRUCTURE‐ACTIVITY RELATIONSHIPS IN A SERIES OF 6‐THIOXANTHINES WITH BRONCHODILATOR AND CORONARY DILATOR PROPERTIES

1961 • 7 citations