Altered GABA neurotransmission and prefrontal cortical dysfunction in schizophrenia

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

1996 • 2,452 citations

Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia

1986 • 2,026 citations

Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey

1979 • 1,496 citations

D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory

1991 • 1,365 citations

Gene Expression for Glutamic Acid Decarboxylase Is Reduced Without Loss of Neurons in Prefrontal Cortex of Schizophrenics

1995 • 1,007 citations

The pyramidal neuron of the cerebral cortex: Morphological and chemical characteristics of the synaptic inputs

1992 • 954 citations

Schizophrenics Show Spatial Working Memory Deficits

1992 • 953 citations

Synaptic patterns on different cell types in the different laminae of the cat visual cortex. An electron microscope study

1968 • 947 citations

Deficits in Small Interneurons in Prefrontal and Cingulate Cortices of Schizophrenic and Schizoaffective Patients

1991 • 889 citations

Abnormally High Neuronal Density in the Schizophrenic Cortex

1995 • 866 citations

Regional and cellular fractionation of working memory

1996 • 821 citations

Parvalbumin in Most γ-Aminobutyric Acid-Containing Neurons of the Rat Cerebral Cortex

1986 • 744 citations

The projections of cells in different layers of the cat's visual cortex

1975 • 726 citations

Local and diffuse synaptic actions of GABA in the hippocampus

1993 • 709 citations

Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia

1998 • 705 citations

Thalamic Abnormalities in Schizophrenia Visualized Through Magnetic Resonance Image Averaging

1994 • 699 citations

The origin of efferent pathways from the primary visual cortex, area 17, of the macaque monkey as shown by retrograde transport of horseradish peroxidase

1975 • 684 citations

Synaptogenesis in the Prefrontal Cortex of Rhesus Monkeys

1994 • 669 citations

Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys

1994 • 574 citations

Pronounced Reduction of Total Neuron Number in Mediodorsal Thalamic Nucleus and Nucleus Accumbens in Schizophrenics

1990 • 558 citations

Physiological subgroups of nonpyramidal cells with specific morphological characteristics in layer II/III of rat frontal cortex

1995 • 548 citations

AN ELECTRON MICROSCOPE STUDY*

1957 • 541 citations

Neuronal and Glial Somal Size in the Prefrontal Cortex

1998 • 530 citations

Mediodorsal nucleus: Areal, laminar, and tangential distribution of afferents and efferents in the frontal lobe of rhesus monkeys

1988 • 516 citations

Brain Morphology and Schizophrenia

1992 • 508 citations

Local circuit neurons immunoreactive for calretinin, calbindin D‐28k or parvalbumin in monkey prefronatal cortex: Distribution and morphology

1994 • 505 citations

Alterations in Brain High-Energy Phosphate and Membrane Phospholipid Metabolism in First-Episode, Drug-Naive Schizophrenics

1991 • 481 citations

Dopamine synaptic complex with pyramidal neurons in primate cerebral cortex.

1989 • 435 citations

Widespread Cerebral Gray Matter Volume Deficits in Schizophrenia

1992 • 421 citations

6-Hydroxydopamine lesions of the prefrontal cortex in monkeys enhance performance on an analog of the Wisconsin Card Sort Test: possible interactions with subcortical dopamine

1994 • 420 citations

A subclass of prefrontal γ-aminobutyric acid axon terminals are selectively altered in schizophrenia

1998 • 408 citations

Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients: Application of a three-dimensional, stereologic counting method

1998 • 394 citations

Functional interactions between inferotemporal and prefrontal cortex in a cognitive task

1985 • 377 citations

Parvalbumin, and intracellular calcium-binding protein; distribution, properties and possible roles in mammalian cells

1984 • 365 citations

Decreased regional cortical gray matter volume in schizophrenia

1994 • 356 citations

Visualization of chandelier cell axons by parvalbumin immunoreactivity in monkey cerebral cortex.

1989 • 341 citations

Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1

1994 • 338 citations

Reduction of Synaptophysin Immunoreactivity in the Prefrontal Cortex of Subjects With Schizophrenia

1997 • 334 citations

Steady states, charge movements, and rates for a cloned GABA transporter expressed in Xenopus oocytes

1993 • 328 citations

PET and MRI of the thalamus in never-medicated patients with schizophrenia

1996 • 319 citations

Regional Brain Abnormalities in Schizophrenia Measured With Magnetic Resonance Imaging

1994 • 318 citations

GAT-1, a high-affinity GABA plasma membrane transporter, is localized to neurons and astroglia in the cerebral cortex

1995 • 318 citations

Coactivation of prefrontal cortex and inferior parietal cortex in working memory tasks revealed by 2DG functional mapping in the rhesus monkey

1994 • 313 citations

Activity-dependent regulation of GABA expression in the visual cortex of adult monkeys

1988 • 278 citations

Up-regulation of GABAA receptor binding on neurons of the prefrontal cortex in schizophrenic subjects

1996 • 275 citations

Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging

1996 • 263 citations

Topography of pyramidal neuron intrinsic connections in macaque monkey prefrontal cortex (areas 9 and 46)

1993 • 260 citations

Synchronous development of pyramidal neuron dendritic spines and parvalbumin-immunoreactive chandelier neuron axon terminals in layer III of monkey prefrontal cortex

1995 • 247 citations

Axon terminals immunolabeled for dopamine or tyrosine hydroxylase synapse on GABA‐immunoreactive dendrites in rat and monkey cortex

1995 • 230 citations

Heterogeneity of chandelier neurons in monkey neocortex: Corticotropin‐releasing factor‐and parvalbumin‐immunoreactive populations

1990 • 221 citations

Local circuit neurons of developing and mature macaque prefrontal cortex: Golgi and immunocytochemical characteristics

1993 • 217 citations

Alterations in synaptic proteins and their encoding mRNAs in prefrontal cortex in schizophrenia: a possible neurochemical basis for ‘hypofrontality’

1999 • 216 citations

Levels of the growth-associated protein GAP-43 are selectively increased in association cortices in schizophrenia

1996 • 210 citations

Total nerve cell number in neocortex in chronic schizophrenics and controls estimated using optical disectors

1993 • 208 citations

Local circuit neurons in the medial prefrontal cortex (areas 24a,b,c, 25 and 32) in the monkey: II. Quantitative areal and laminar distributions

1996 • 206 citations

Patterns of intrinsic and associational circuitry in monkey prefrontal cortex

1996 • 204 citations

INCREASED DOPAMINE CONCENTRATION IN LIMBIC AREAS OF BRAIN FROM PATIENTS DYING WITH SCHIZOPHRENIA

1979 • 203 citations

An In Vivo Study of the Prefrontal Cortex of Schizophrenic Patients at Different Stages of Illness via Phosphorus Magnetic Resonance Spectroscopy

1995 • 203 citations

Deficit and hemispheric asymmetry of GABA uptake sites in the hippocampus in schizophrenia

1990 • 202 citations

Reduced GABA uptake sites in the temporal lobe in schizophrenia

1989 • 198 citations

Brain Anatomic Magnetic Resonance Imaging in Childhood-Onset Schizophrenia

1996 • 198 citations

Schizophrenia and the parvalbumin-containing class of cortical local circuit neurons

1997 • 194 citations

Local circuit neurons of the prefrontal cortex in schizophrenia: selective increase in the density of calbindin-immunoreactive neurons

1995 • 186 citations

GABA_A Receptor Subunit Gene Expression in Human Prefrontal Cortex: Comparison of Schizophrenics and Controls

1995 • 182 citations

Prefrontal Cortex and Schizophrenia

1995 • 170 citations

Peripubertal refinement of the intrinsic and associational circuitry in monkey prefrontal cortex

1997 • 160 citations

Evidence of glutamatergic deficiency in schizophrenia

1991 • 154 citations

Dopamine innervation of a subclass of local circuit neurons in monkey prefrontal cortex: ultrastructural analysis of tyrosine hydroxylase and parvalbumin immunoreactive structures

1998 • 151 citations

Altered ratios of alternatively spliced long and short γ2 subunit mRNAs of the γ-amino butyrate type A receptor in prefrontal cortex of schizophrenics

1998 • 138 citations

Activity-dependent Changes in GAD and Preprotachykinin mRNAs in Visual Cortex of Adult Monkeys

1994 • 135 citations

Increased Concentrations of Presynaptic Proteins in the Cingulate Cortex of Subjects With Schizophrenia

1997 • 127 citations

Synaptic targets of pyramidal neurons providing intrinsic horizontal connections in monkey prefrontal cortex

1998 • 122 citations

Neurodevelopment and Adult Psychopathology

1997 • 111 citations

An In Vivo Proton Magnetic Resonance Spectroscopy Study of Schizophrenia Patients

1996 • 98 citations

The hierarchical development of monkey visual cortical regions as revealed by the maturation of parvalbumin-immunoreactive neurons

1996 • 98 citations

Parvalbumin-immunoreactive axon terminals in macaque monkey and human prefrontal cortex: Laminar, regional, and target specificity of type I and type II synapses

1999 • 91 citations

Proton magnetic resonance spectroscopy of the left medial temporal and frontal lobes in chronic schizophrenia: preliminary report

1995 • 86 citations

Decreased left frontal lobe N-acetylaspartate in schizophrenia

1997 • 83 citations

The functional architecture of the prefrontal cortex and schizophrenia

1995 • 78 citations

Neurodevelopment and Adult Psychopathology

1998 • 77 citations

Correlations of phosphomonoesters measured by phosphorus-31 magnetic resonance spectroscopy in the frontal lobes and negative symptoms in schizophrenia

1994 • 75 citations

Synaptic Connections of Calretinin-Immunoreactive Neurons in the Human Neocortex

1997 • 75 citations

Ultrastructural associations between dopamine terminals and local circuit neurons in the monkey prefrontal cortex: a study of calretinin-immunoreactive cells

1995 • 72 citations

Spine formation and maturation of type 1 synapses on spiny stellate neurons in primate visual cortex

1983 • 59 citations

Differential distribution of parvalbumin-immunoreactive pericellular clusters of terminal boutons in developing and adult monkey neocortex

1992 • 59 citations

Postnatal development of thalamic recipient neurons in the monkey striate cortex: Comparison of spine acquisition and dendritic growth of layer 4C alpha and beta spiny stellate neurons

1991 • 53 citations

Magnetic resonance imaging volumetric and phosphorus 31 magnetic resonance spectroscopy measurements in schizophrenia.

1997 • 35 citations

Specificity of decreased spine density on layer III pyramidal cells in schizophrenia

1997 • 7 citations