Multistage carcinogenesis involves multiple genes and multiple mechanisms

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

DNA Methylation and Gene Function

1980 • 2,069 citations

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1983 • 1,952 citations

Cellular differentiation, cytidine analogs and DNA methylation

1980 • 1,803 citations

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

1982 • 1,790 citations

Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis

1981 • 1,611 citations

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

1982 • 1,398 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address.

1978 • 938 citations

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 • 890 citations

Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas

1982 • 624 citations

Cellular Transforming Genes

1982 • 622 citations

Specific chromosomal translocations and the genesis of B-cell-derived tumors in mice and men

1983 • 517 citations

Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

1983 • 446 citations

Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1

1983 • 377 citations

Human Cell Hybrids: Analysis of Transformation and Tumorigenicity

1982 • 349 citations

Studies on the mechanism of skin tumor promotion: Evidence for several stages in promotion

1980 • 336 citations

Malignant conversion of mouse skin tumours is increased by tumour initiators and unaffected by tumour promoters

1983 • 325 citations

Carcinogenesis—A Comprehensive survey

1982 • 311 citations

Tumour promotion by TCDD in skin of HRS/J hairless mice

1982 • 293 citations

Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C.

1983 • 291 citations

Tumour promoter induces anchorage independence irreversibly

1979 • 285 citations

Inhibition of DNA methylation by chemical carcinogens in vitro

1983 • 252 citations

Activation of mouse genes in transformed cells

1983 • 252 citations

Activation of the Transforming Potential of a Normal Cell Sequence: A Molecular Model for Oncogenesis

1981 • 246 citations

Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like element

1982 • 232 citations

Retroviral transforming genes in normal cells?

1983 • 225 citations

Retrovirus-like particles containing RNA homologous to the transposable element copia in Drosophila melanogaster

1983 • 215 citations

Phorbol ester and diacylglycerol induce protein phosphorylation at tyrosine

1983 • 214 citations

Tumor promoter induces sister chromatid exchanges: relevance to mechanisms of carcinogenesis.

1978 • 206 citations

Identification and molecular cloning of the human Blym transforming gene activated in Burkitt's lymphomas

1983 • 192 citations

Intracisternal A-particle genes as movable elements in the mouse genome.

1983 • 162 citations

Cancer a Comprehensive Treatise 2

1975 • 160 citations

Tumor cell heterogeneity : origins and implications

1982 • 159 citations

Specific binding of phorbol ester tumor promoters to mouse skin

1980 • 152 citations

Cloned endogenous retroviral sequences from human DNA.

1982 • 150 citations

Molecular and Cellular Aspects of Carcinogen Screening Tests

1981 • 150 citations

Function of the retrovirus long terminal repeat

1982 • 148 citations

Tumour promoters induce mitotic aneuploidy in yeast

1981 • 144 citations

A Molecular Basis of Cancer

1983 • 133 citations

Current concepts and controversies in chemical carcinogenesis

1981 • 126 citations

Similarity of teleocidin B and phorbol ester tumour promoters in effects on membrane receptors

1981 • 116 citations

Identification of receptors for phorbol ester tumor promoters in intact mammalian cells and of an inhibitor of receptor binding in biologic fluids.

1981 • 114 citations

Effect of tumor promoters, protease inhibitors, and repair processes on x-ray-induced sister chromatid exchanges in mouse cells.

1979 • 104 citations

Cancer genes come of age

1983 • 98 citations

A tumor promoter stimulates phosphorylation on tyrosine

1983 • 92 citations

Endogenous murine leukemia proviral long terminal repeats contain a unique 190-base-pair insert.

1983 • 91 citations

Characterization and partial nucleotide sequence of endogenous type C retrovirus segments in human chromosomal DNA.

1983 • 88 citations

Organization of the endogenous proviruses of chickens: Implications for origin and expression

1981 • 86 citations

Rearranged c-mos locus in a MOPC 21 murine myeloma cell line and its persistence in hybridomas

1983 • 84 citations

Phorbol esters stimulate the rapid release of choline from prelabelled cells

1981 • 83 citations

Suppression of tumor promoter phorbolmyristate acetate-induced chromosome breakage by antioxidants and inhibitors of arachidonic acid metabolism

1983 • 82 citations

Carcinogen-mediated induction of SV40 DNA synthesis in SV40 transformed Chinese hamster embryo cells

1981 • 81 citations

The U3 portion of feline leukemia virus DNA identifies horizontally acquired proviruses in leukemic cats.

1981 • 80 citations

Interaction of benzo(a)pyrene and its dihydrodiol-epoxide derivative with nuclear and mitochondrial DNA in C3H10T 1/2 cell cultures.

1982 • 76 citations

Tumor promoters and epidermal growth factor stimulate anchorage-independent growth of adenovirus-transformed rat embryo cells

1979 • 69 citations

Cellular Moloney Murine Sarcoma (c-mos) Sequences Are Hypermethylated and Transcriptionally Silent in Normal and Transformed Rodent Cells

1982 • 66 citations

Mitogenic hormones and tumor promoters greatly increase the incidence of colony-forming cells bearing amplified dihydrofolate reductase genes.

1983 • 61 citations

Genetics of Susceptibility to Plasmacytoma Induction. I. BALB/cAnN (C), C57BL/6N (B6), C57BL/Ka (BK), (C × B6)F 1 , (C × BK) F 1 , and C × B Recombinant-Inbred Strains

1975 • 59 citations

Design of a Retrovirus-Derived Vector for Expression and Transduction of Exogenous Genes in Mammalian Cells

1983 • 56 citations

Comparative effects of aplysiatoxin, debromoaplysiatoxin, and teleocidin on receptor binding and phospholipid metabolism.

1983 • 55 citations

Use of epithelial cell cultures for studies on the mechanism of transformation by chemical carcinogens

1975 • 54 citations

Tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate enhances sister chromatid exchanges and numerical and structural chromosome aberrations in primary mouse epidermal cell cultures

1982 • 54 citations

Factors which affect DNA strand breakage in human leukocytes exposed to a tumor promoter, phorbol myristate acetate

1982 • 52 citations

Tumour promoters:Protein kinase, phospholipid and control of growth

1983 • 50 citations

Epstein-Barr virus activation by tung oil, extracts of Aleurites fordii and its diterpene ester 12-O-hexadecanoyl-16-hydroxyphorbol-13-acetate

1983 • 48 citations

Benzo[a]pyrene induction of extrachromosomal viral DNA synthesis in rat cells transformed by polyoma virus

1983 • 47 citations

Alteration of Enzymatic Methylation of DNA Cytosines by Chemical Carcinogens: A Mechanism Involved in the Initiation of Carcinogenesis<xref ref-type="fn" rid="FN3">3</xref>

1983 • 45 citations

Benzo[a]pyrene and other inducers of cytochrome P₁-450 inhibit binding of epidermal growth factor to cell surface receptors

1982 • 42 citations

Retrovirus-related sequences in human DNA: detection and cloning of sequences which hybridize with the long terminal repeat of baboon endogenous virus

1982 • 38 citations

Cellular Moloney murine sarcoma (c-mos) sequences are hypermethylated and transcriptionally silent in normal and transformed rodent cells.

1982 • 38 citations

Organization and expression of endogenous virus-like (VL30) DNA sequences in nontransformed and chemically transformed mouse embryo cells in culture.

1982 • 37 citations

Carcinogen- and radiation-transformed C3H 10T1/2 cells contain RNAs homologous to the long terminal repeat sequence of a murine leukemia virus.

1982 • 35 citations

Effects of teleocidin and the phorbol ester tumor promoters on cell transformation, differentiation, and phospholipid metabolism.

1982 • 30 citations

DNA hypomethylation in Morris hepatomas

1983 • 29 citations

Normal cells of patients with high cancer risk syndromes lack transforming activity in the NIH/3T3 transfection assay

1983 • 29 citations

Studies on the mechanism by which a tumor promoter inhibits binding of epidermal growth factor to cellular receptors

1980 • 17 citations

Evidence for a new form of retroviral env transcript in leukemic and normal mouse lymphoid cells

1983 • 17 citations

Chemical-viral interactions and multistep aspects of cell transformation.

1980 • 16 citations

Inhibition of respiration by a phorbol ester tumor promoter in murine cultured cells

1982 • 15 citations

Analysis of recombinant DNA clones of the endogenous BALB/c murine leukemia virus WN1802N: variation in long terminal repeat length

1983 • 15 citations

Common multigenic activation in different human neoplasias.

1983 • 13 citations

Tumor promoter 12-O-tetradecanoylphorbol 13-acetate alters state, fluidity and hydration of 1,2-diacyl-sn-glycero-3-phosphocholine bilayers

1983 • 13 citations

Interaction between phorbol esters and phospholipid in a monolayer model membrane

1982 • 9 citations

Differential Effect of Tumor Promoters on Phorbol‐Ester‐Receptor Binding and Membrane Fluorescence Anisotropy in C3H 10 T 1/2 Cells

1983 • 9 citations

Presence of a novel recombinant murine leukemia virus-like glycoprotein on the surface of virus-negative C57BL lymphoma cells.

1982 • 7 citations