Therapeutic Implications of the Cancer Stem Cell Hypothesis

Prospective identification of tumorigenic breast cancer cells

2003 • 10,067 citations

Stem cells, cancer, and cancer stem cells

2001 • 9,488 citations

Identification of human brain tumour initiating cells

2004 • 7,166 citations

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

1997 • 6,760 citations

Identification of stem cells in small intestine and colon by marker gene Lgr5

2007 • 5,173 citations

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

1994 • 4,563 citations

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

2006 • 4,012 citations

ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome

2007 • 3,824 citations

Tumour stem cells and drug resistance

2005 • 3,535 citations

Identification of Pancreatic Cancer Stem Cells

2007 • 3,239 citations

Prospective Identification of Tumorigenic Prostate Cancer Stem Cells

2005 • 2,784 citations

Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer

2007 • 2,743 citations

CD44: From adhesion molecules to signalling regulators

2003 • 2,236 citations

Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma

2007 • 2,139 citations

Phenotypic characterization of human colorectal cancer stem cells

2007 • 2,114 citations

Generation of a functional mammary gland from a single stem cell

2006 • 1,939 citations

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

2003 • 1,851 citations

Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy

2008 • 1,755 citations

Primary Bioassay of Human Tumor Stem Cells

1977 • 1,625 citations

Purification and unique properties of mammary epithelial stem cells

2006 • 1,502 citations

Granulocyte–Macrophage Progenitors as Candidate Leukemic Stem Cells in Blast-Crisis CML

2004 • 1,472 citations

Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9

2006 • 1,430 citations

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

2006 • 1,273 citations

A distinct “side population” of cells with high drug efflux capacity in human tumor cells

2004 • 1,259 citations

Hedgehog Signaling and Bmi-1 Regulate Self-renewal of Normal and Malignant Human Mammary Stem Cells

2006 • 1,209 citations

Targeting of CD44 eradicates human acute myeloid leukemic stem cells

2006 • 1,177 citations

Significance of CD90+ Cancer Stem Cells in Human Liver Cancer

2008 • 1,154 citations

Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells

2006 • 1,148 citations

Colon Cancer Stem Cells Dictate Tumor Growth and Resist Cell Death by Production of Interleukin-4

2007 • 1,004 citations

Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice.

1959 • 985 citations

The Prognostic Role of a Gene Signature from Tumorigenic Breast-Cancer Cells

2007 • 985 citations

Side Population in Human Lung Cancer Cell Lines and Tumors Is Enriched with Stem-like Cancer Cells

2007 • 939 citations

Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region

2007 • 921 citations

Side Population Is Enriched in Tumorigenic, Stem-Like Cancer Cells, whereas ABCG2+ and ABCG2− Cancer Cells Are Similarly Tumorigenic

2005 • 905 citations

Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells

2004 • 739 citations

The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells

2005 • 666 citations

Most Early Disseminated Cancer Cells Detected in Bone Marrow of Breast Cancer Patients Have a Putative Breast Cancer Stem Cell Phenotype

2006 • 654 citations

Irinotecan Plus Gemcitabine Results in No Survival Advantage Compared With Gemcitabine Monotherapy in Patients With Locally Advanced or Metastatic Pancreatic Cancer Despite Increased Tumor Response Rate

2004 • 581 citations

Colorectal Cancer Stem Cells Are Enriched in Xenogeneic Tumors Following Chemotherapy

2008 • 575 citations

HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion

2008 • 555 citations

An entire functional mammary gland may comprise the progeny from a single cell

1998 • 544 citations

The CD44+/CD24-phenotype is enriched in basal-like breast tumors

2008 • 544 citations

Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

2004 • 532 citations

A critique of the evidence for active host defence against cancer, based on personal studies of 27 murine tumours of spontaneous origin

1976 • 478 citations

Multiple Drug Resistance in Cancer Revisited: The Cancer Stem Cell Hypothesis

2005 • 448 citations

CD44 in Cancer Progression: Adhesion, Migration and Growth Regulation

2003 • 429 citations

Epigenetic-Mediated Dysfunction of the Bone Morphogenetic Protein Pathway Inhibits Differentiation of Glioblastoma-Initiating Cells

2008 • 426 citations

A Quantitative Assay for the Number of Murine Lymphoma Cells capable of Proliferation in vivo

1963 • 401 citations

Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling

2007 • 297 citations

Differential Expression of Novel Potential Regulators in Hematopoietic Stem Cells

2005 • 281 citations

Isolation and Molecular Characterization of Cancer Stem Cells in MMTV-Wnt-1 Murine Breast Tumors

2007 • 277 citations

Acute nonlymphocytic leukemia: heterogeneity of stem cell origin

1981 • 259 citations

Acute nonlymphocytic leukemia: heterogeneity of stem cell origin

1981 • 215 citations

Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion

2008 • 183 citations

Differential gene expression profiling of adult murine hematopoietic stem cells

2002 • 170 citations

Establishment of Human Colon Cancer Cell Lines from Fresh Tumors versus Xenografts: Comparison of Success Rate and Cell Line Features

2007 • 168 citations

Contiguous patches of normal human mammary epithelium derived from a single stem cell: implications for breast carcinogenesis.

1996 • 163 citations

A Stochastic Model for Cancer Stem Cell Origin in Metastatic Colon Cancer

2008 • 162 citations

The paradox of response and survival in cancer therapeutics

2005 • 145 citations

Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts

2008 • 127 citations

The proportion of stem cells in murine tumors

1989 • 116 citations

Use Of Genetic Markers To Study Cellular Origin And Development Of Tumors In Human Females

1972 • 103 citations

Randomised phase III study of intravenous vinorelbine plus hormone therapy versus hormone therapy alone in hormone-refractory prostate cancer

2004 • 83 citations

Drug Insight: intracellular inhibitors of HER2—clinical development of lapatinib in breast cancer

2008 • 74 citations

Evaluation of Surviving Fraction at 2 Gy as a Potential Prognostic Factor for the Radiotherapy of Carcinoma of the Cervix

1989 • 73 citations

Neural progenitor genes

2003 • 68 citations

Invincible, but Not Invisible: Imaging Approaches Toward In Vivo Detection of Cancer Stem Cells

2008 • 62 citations

Molecular Cloning and Characterization of a Novel Regulator of G-protein Signaling from Mouse Hematopoietic Stem Cells

2001 • 59 citations

Stem cell origin of human myeloid blood cell neoplasms.

1990 • 32 citations

Facts and controversies in the use of trastuzumab in the adjuvant setting

2008 • 19 citations

Identification and distribution of megakaryocyte colonies in murine spleen

1983 • 2 citations

Deleted Work

1955 • 0 citations