Phenobarbital and some other liver tumor promoters stimulate DNA synthesis in cultured rat hepatocytes

A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid

1956 • 14,202 citations

The stages of initiation and promotion in hepatocarcinogenesis

1980 • 515 citations

Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters

1984 • 369 citations

Induction of Liver Growth by Xenobiotic Compounds and Other Stimuli

1974 • 352 citations

DNA synthesis in primary cultures of adult rat hepatocytes in a defined medium: Effects of epidermal growth factor, insulin, glucagon, and cyclic‐AMP

1981 • 345 citations

Liver regeneration studies with rat hepatocytes in primary culture.

1982 • 293 citations

Comparative enhancing effects of phenobarbital, amobarbital, diphenylhydantoin, and dichlorodiphenyltrichloroethane on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.

1975 • 257 citations

Partial characterization of a hepatocyte growth factor from rat platelets

1984 • 251 citations

STUDIES ON PRIMARY CULTURES OF DIFFERENTIATED FETAL LIVER CELLS

1972 • 249 citations

Density-Dependent Growth Control of Adult Rat Hepatocytes in Primary Culture1

1983 • 199 citations

Enhanced proliferation of putative preneoplastic cells in rat liver following treatment with the tumor promoters phenobarbital, hexachlorocyclohexane, steroid compounds, and nafenopin.

1981 • 193 citations

The natural history and dose-response characteristics of enzyme-altered foci in rat liver following phenobarbital and diethylnitrosamine administration

1984 • 121 citations

7-ethoxycoumarin deethylase activity as a convenient measure of liver drug metabolizing enzymes: Regulation in cultured rat hepatocytes

1984 • 98 citations

Effects of varying the dietary concentration of phenobarbital on its enhancement of 2-acetylaminofluorene-induced hepatic tumorigenesis.

1980 • 97 citations

Stimulation of DNA synthesis and cell proliferation in the liver of rats fed a choline-devoid diet and their suppression by phenobarbital.

1982 • 80 citations

Regulation of gamma-glutamyltranspeptidase in rat hepatocyte monolayer cultures.

1982 • 69 citations

Exogenous Cu,Zn-superoxide dismutase suppresses the stimulation of neonatal rat hepatocytes' growth by tumor promoters

1984 • 53 citations

Failure to discriminate initiation from promotion of liver tumors in a long-term study with the phenobarbital-type inducer alpha-hexachlorocyclohexane and the role of sustained stimulation of hepatic growth and monooxygenases.

1981 • 38 citations

Measurement of cholic acid synthesis and secretion by isolated rat hepatocytes.

1979 • 33 citations

Induction of γ-glutamyl transpeptidase in primary cultures of normal rat hepatocytes by liver tumor promoters and structurally related compounds

1985 • 23 citations

Relationship between inductions of monooxygenase activity and γ-glutamyltranspeptidase in rat hepatocyte primary cultures

1984 • 7 citations