Tumor necrosis factor-induced degranulation in adherent human neutrophils is dependent on CD11b/CD18-integrin-triggered oscillations of cytosolic free Ca2+.

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

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An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Integrins: A family of cell surface receptors

1987 • 4,322 citations

Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.

1985 • 1,056 citations

A plaque assay for all cells secreting Ig of a given type or class

1976 • 1,034 citations

Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.

1985 • 922 citations

A human leukocyte differentiation antigen family with distinct alpha-subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule.

1983 • 888 citations

Stimulation of neutrophils by tumor necrosis factor.

1986 • 847 citations

Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.

1987 • 823 citations

Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins.

1989 • 577 citations

Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes.

1987 • 533 citations

Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytes.

1983 • 495 citations

Contributions of the Mac-1 glycoprotein family to adherence-dependent granulocyte functions: structure-function assessments employing subunit-specific monoclonal antibodies.

1986 • 423 citations

Increased surface expression of CD11b/CD18 (Mac-1) is not required for stimulated neutrophil adherence to cultured endothelium.

1988 • 333 citations

Respiratory burst in adherent human neutrophils: triggering by colony- stimulating factors CSF-GM and CSF-G

1989 • 277 citations

Leukocyte adhesion receptors are stored in peroxidase-negative granules of human neutrophils.

1987 • 229 citations

Leukocyte function-associated antigen 1 is an activation molecule for human T cells.

1989 • 177 citations

Heterogeneous distribution and transmembrane signaling properties of lymphocyte function-associated antigen (LFA-1) in human lymphocyte subsets.

1989 • 158 citations

The cell surface glycoprotein Mac-1 (CD11b/CD18) mediates neutrophil adhesion and modulates degranulation independently of its quantitative cell surface expression.

1989 • 158 citations

Characterization of fMet-Leu-Phe receptor-mediated Ca2+ influx across the plasma membrane of human neutrophils.

1986 • 157 citations

Serum Myeloperoxidase and Lactoferrin in Neutropenia

1977 • 143 citations

Leucocyte Adhesion to Cells

1989 • 138 citations

Ligated complement receptors do not activate the arachidonic acid cascade in resident peritoneal macrophages.

1985 • 128 citations

Effect of tumor necrosis factor and granulocyte/macrophage colony-stimulating factor on neutrophil degranulation.

1989 • 125 citations

The Importance of the Mac‐1, LFA‐1 Glycoprotein Family in Monocyte and Granulocyte Adherence, Chemotaxis, and Migration into Inflammatory Sites: Insights from an Experiment of Nature

1986 • 111 citations

Spontaneous and chemoattractant-induced oscillations of cytosolic free calcium in single adherent human neutrophils.

1988 • 106 citations

Polymorphonuclear leukocyte adherence induces actin polymerization by a transduction pathway which differs from that used by chemoattractants.

1989 • 98 citations

Tumor necrosis factor alpha modifies agonist-dependent responses in human neutrophils by inducing the synthesis and myristoylation of a specific protein kinase C substrate.

1990 • 95 citations

Biochemical Mechanisms Involved in the Priming of Neutrophils by Tumor Necrosis Factor

1988 • 80 citations

Cell surface expression of fMet-Leu-Phe receptors on human neutrophils. Correlation to changes in the cytosolic free Ca2+ level and action of phorbol myristate acetate.

1987 • 68 citations

Identification of a Cell‐Surface Glycoprotein Mediating Adhesion in Human Granulocytes

1985 • 64 citations

Cachectin/tumor necrosis factor and other cytokines in infectious disease

1989 • 60 citations

Early Biochemical Events in Leukocyte Activation

1989 • 53 citations

Correlation between spontaneous oscillations of cytosolic free Ca2+ and tumor necrosis factor-induced degranulation in adherent human neutrophils.

1990 • 34 citations

Effect of tumor necrosis factor on granule release and LTB4 production in adherent human polymorphonuclear leukocytes

1989 • 20 citations