Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-x_L from NMR and Parallel Synthesis

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

2005 • 3,292 citations

Small-molecule inhibitors of protein–protein interactions: progressing towards the dream

2004 • 1,614 citations

The Bcl-2 family: roles in cell survival and oncogenesis

2003 • 1,448 citations

Structure of Bcl-x _L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

1997 • 1,429 citations

A Protein-Counting Mechanism for Telomere Length Regulation in Yeast

1997 • 514 citations

Rationale for Bcl‐X_L/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

2000 • 388 citations

A manual method for applying the Hansch approach to drug design

1977 • 205 citations

Sampling and efficiency of metric matrix distance geometry: A novel partial metrization algorithm

1992 • 204 citations

A statistical-heuristic method for automated selection of drugs for screening

1977 • 69 citations

Molecular diversity: how we measure it? Has it lived up to its promise?

2001 • 10 citations

Small-molecule inhibitors of Bcl-2 protein

2004 • 8 citations