Cannabinoid CB1 receptors control conditioned drug seeking

The neural basis of drug craving: An incentive-sensitization theory of addiction

1993 • 7,074 citations

Dopamine, learning and motivation

2004 • 3,146 citations

Cannabinoid receptor localization in brain.

1990 • 2,248 citations

The endogenous cannabinoid system controls extinction of aversive memories

2002 • 1,689 citations

The reinstatement model of drug relapse: history, methodology and major findings

2002 • 1,586 citations

Leptin-regulated endocannabinoids are involved in maintaining food intake

2001 • 1,557 citations

Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study

2005 • 1,509 citations

Endocannabinoid Signaling in the Brain

2002 • 1,240 citations

Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons

1999 • 1,169 citations

Cannabinoid and Heroin Activation of Mesolimbic Dopamine Transmission by a Common µ ₁ Opioid Receptor Mechanism

1997 • 1,078 citations

Neurobiology of Relapse to Heroin and Cocaine Seeking: A Review

2002 • 874 citations

Endogenous Cannabinoids Mediate Retrograde Signals from Depolarized Postsynaptic Neurons to Presynaptic Terminals

2001 • 816 citations

The effects of cannabinoids on the brain

1999 • 788 citations

Dopamine activation of endogenous cannabinoid signaling in dorsal striatum

1999 • 773 citations

2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB ₁ receptor

2001 • 752 citations

Associative Processes in Addiction and Reward The Role of Amygdala‐Ventral Striatal Subsystems

1999 • 713 citations

Stress-induced relapse to heroin and cocaine seeking in rats: a review

2000 • 695 citations

The addicted human brain viewed in the light of imaging studies: brain circuits and treatment strategies

2004 • 603 citations

Brain circuitry and the reinstatement of cocaine-seeking behavior

2003 • 592 citations

Cue-induced activation of the striatum and medial prefrontal cortex is associated with subsequent relapse in abstinent alcoholics

2004 • 575 citations

Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist

1999 • 565 citations

Limbic and Motor Circuitry Underlying Footshock-Induced Reinstatement of Cocaine-Seeking Behavior

2004 • 518 citations

Opposite Modulation of Cocaine-Seeking Behavior by D ₁ - and D ₂ -Like Dopamine Receptor Agonists

1996 • 493 citations

A cannabinoid mechanism in relapse to cocaine seeking

2001 • 434 citations

Brain Metabolic Changes During Cigarette Craving

2002 • 422 citations

A role for the prefrontal cortex in stress- and cocaine-induced reinstatement of cocaine seeking in rats

2002 • 414 citations

Control of cocaine-seeking behavior by drug-associated stimuli in rats: Effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens

2000 • 412 citations

SR141716, a central cannabinoid (CB1) receptor antagonist, blocks the motivational and dopamine-releasing effects of nicotine in rats

2002 • 397 citations

Stress-induced craving and stress response in cocaine dependent individuals

1999 • 390 citations

Selective inactivation of the dorsomedial prefrontal cortex and the basolateral amygdala attenuates conditioned-cued reinstatement of extinguished cocaine-seeking behavior in rats

2002 • 387 citations

Functional Interaction between Opioid and Cannabinoid Receptors in Drug Self-Administration

2001 • 367 citations

Pathways to relapse: the neurobiology of drug- and stress-induced relapse to drug-taking.

2000 • 360 citations

Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys

2000 • 344 citations

Behavioral Effects of Cannabinoid Agents in Animals

1999 • 311 citations

Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine

2002 • 274 citations

Priming effects with drugs and other reinforcers.

1996 • 269 citations

Cannabinoid CB1 receptor knockout mice fail to self-administer morphine but not other drugs of abuse

2001 • 266 citations

Circuitry for Associative Plasticity in the Amygdala Involves Endocannabinoid Signaling

2004 • 261 citations

Nicotine-Associated Cues Maintain Nicotine-Seeking Behavior in Rats Several Weeks after Nicotine Withdrawal: Reversal by the Cannabinoid (CB1) Receptor Antagonist, Rimonabant (SR141716)

2004 • 255 citations

Classically Conditioned Responses in Opioid and Cocaine Dependence: A Role in Relapse?

1988 • 249 citations

A Role of Ventral Tegmental Area Glutamate in Contextual Cue-Induced Relapse to Heroin Seeking

2004 • 244 citations

Dopaminergic mechanisms mediating the incentive to seek cocaine and heroin following long-term withdrawal of IV drug self-administration

1999 • 218 citations

Dissociation of Primary and Secondary Reward-Relevant Limbic Nuclei in an Animal Model of Relapse

2000 • 213 citations

A single in-vivo exposure to Δ9THC blocks endocannabinoid-mediated synaptic plasticity

2004 • 211 citations

The motivation for beer in rats: effects of ritanserin, naloxone and SR 141716

1999 • 203 citations

Neural integrative activities of nucleus accumbens subregions in relation to learning and motivation

1999 • 196 citations

Cannabinoid modulation of the reinforcing and motivational properties of heroin and heroin-associated cues in rats

2003 • 194 citations

Basolateral amygdala inactivation abolishes conditioned stimulus- and heroin-induced reinstatement of extinguished heroin-seeking behavior in rats

2002 • 194 citations

The Cannabinoid CB1 Antagonist N-Piperidinyl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl) -4-methylpyrazole-3-carboxamide (SR-141716A) Differentially Alters the Reinforcing Effects of Heroin under Continuous Reinforcement, Fixed Ratio, and Progressive Ratio Schedules of Drug Self-Administration in Rats

2003 • 191 citations

Functions of cannabinoid receptors in the hippocampus

2002 • 178 citations

Importance of nonpharmacological factors in nicotine self-administration

2002 • 178 citations

Effect of low doses of ?9-tetrahydrocannabinol and cannabidiol on the extinction of cocaine-induced and amphetamine-induced conditioned place preference learning in rats

2004 • 156 citations

Cannabinoid mechanism in reinstatement of heroin‐seeking after a long period of abstinence in rats

2003 • 130 citations

Endocannabinoid System Modulates Relapse to Methamphetamine Seeking: Possible Mediation by the Arachidonic Acid Cascade

2004 • 123 citations

Suppression of conditioned nicotine and sucrose seeking by the cannabinoid-1 receptor antagonist SR141716A

2005 • 107 citations

Cannabinoids inhibit GABAergic synaptic transmission in mice nucleus accumbens

2001 • 99 citations

Inhibitory effects of SR141716A on G-protein activation in rat brain

2001 • 94 citations

Classically conditioned responses in opioid and cocaine dependence: A role in relapse?

1988 • 80 citations

SR141716, a CB1 receptor antagonist, decreases the sensitivity to the reinforcing effects of electrical brain stimulation in rats

2001 • 70 citations

Cannabis and alcohol – a close friendship

2003 • 67 citations

Δ9-THC REINSTATES BEER- AND SUCROSE-SEEKING BEHAVIOUR IN ABSTINENT RATS: COMPARISON WITH MIDAZOLAM, FOOD DEPRIVATION AND PREDATOR ODOUR

2004 • 45 citations

Rats on the grog: Novel pharmacotherapies for alcohol craving

2004 • 36 citations