Repeated ethanol withdrawal experience increases the severity and duration of subsequent withdrawal seizures in mice

A permanent change in brain function resulting from daily electrical stimulation

1969 • 3,056 citations

Kindling as a Model for Alcohol Withdrawal Syndromes

1978 • 470 citations

Relationship of alcohol dose to intensity of withdrawal signs in mice.

1972 • 329 citations

Alcohol detoxification and withdrawal seizures: Clinical support for a kindling hypothesis

1988 • 286 citations

Repeated Episodes of Ethanol Withdrawal Potentiate the Severity of Subsequent Withdrawal Seizures: An Animal Model of Alcohol Withdrawal “Kindling”

1993 • 284 citations

Multiple Withdrawals from Chronic Ethanol “Kindles” Inferior Collicular Seizure Activity: Evidence for Kindling of Seizures Associated with Alcoholism

1990 • 155 citations

The Kindling Model of Alcohol Dependence: Similar Persistent Reduction in Seizure Threshold to Pentylenetetrazol in Animals Receiving Chronic Ethanol or Chronic Pentylenetetrazol

1993 • 148 citations

THE KINDLING HYPOTHESIS: FURTHER EVIDENCE FROM A U.S. NATIONAL STUDY OF ALCOHOLIC MEN<xref ref-type="fn" rid="fn1"><sup>*</sup></xref>

1993 • 129 citations

Alcohol withdrawal in mice: Electroencephalographic and behavioral correlates

1974 • 126 citations

Positive relationship between the number of prior ethanol withdrawal episodes and the severity of subsequent withdrawal seizures

1994 • 111 citations

Calculus: One and Several Variables

1991 • 98 citations

Repeated Ethanol Withdrawal Produces Site‐Dependent Increases in EEG Spiking

1996 • 97 citations

Seizure Risk With Recurrent Alcohol Detoxification

1990 • 80 citations

Physical Dependence on Ethanol During Multiple Intoxication and Withdrawal Episodes in the Rat: Evidence of a Potentiation

1984 • 69 citations

Exacerbation of Ethanol Withdrawal Seizures in Mice With a History of Multiple Withdrawal Experience

1997 • 66 citations

The effect of repeated withdrawal episodes on subsequent withdrawal severity in ethanol-treated rats

1989 • 53 citations

Electroencephalographic and behavioral correlates in rats during repeated ethanol withdrawal syndromes

1984 • 52 citations

Alcohol withdrawal in mice: electroencephalogra-phic and behavioural correlates

1974 • 51 citations

Alcohol and Seizures: Basic Mechanisms and Clinical Concepts

1990 • 46 citations

Alcohol and seizures : basic mechanisms and clinical concepts

1990 • 28 citations

Pyrazole exacerbates handling-induced convulsions in mice

1981 • 18 citations