Uveitogenic T lymphocytes in the rat: pathogenicity vs. lymphokine production, adhesion molecules and surface antigen expression

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor.

1991 • 470 citations

Immunodetection and quantitation of the two forms of transforming growth factor‐beta (TGF‐β1 and TGF‐β2) secreted by cells in culture

1989 • 453 citations

A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens.

1988 • 451 citations

T cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat.

1986 • 358 citations

Activated T lymphocytes produce a matrix-degrading heparan sulphate endoglycosidase

1984 • 344 citations

Chapter 3 Retinal specific antigens and immunopathogenic processes they provoke

1986 • 289 citations

Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity

1990 • 285 citations

Autoimmunity and the retina.

1980 • 222 citations

The role of cytokines in the pathogenesis of inflammatory eye disease

1992 • 218 citations

Adoptive transfer of experimental autoimmune uveoretinitis in rats. Immunopathogenic mechanisms and histologic features.

1985 • 213 citations

Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. Severe paralytic disease correlates with the presence of interleukin 2 receptor-positive cells infiltrating the central nervous system.

1987 • 182 citations

Cytokines and uveitis, a review

1992 • 146 citations

T lymphocyte lines producing or vaccinating against autoimmune encephalomyelitis (EAE). Functional activation induces peanut agglutinin receptors and accumulation in the brain and thymus of line cells

1983 • 145 citations

Experimental allergic encephalomyelitis mediated by cloned T cells specific for a synthetic peptide of myelin proteolipid protein. Fine specificity and T cell receptor V beta usage.

1992 • 135 citations

Cytokine-mediated activation of a neuronal retinal resident cell provokes antigen presentation.

1990 • 126 citations

Enhanced tumor cell adhesion to the subendothelial matrix resulting from 12(S)‐HETE‐induced endothelial cell retraction

1989 • 122 citations

Organ-Resident, Nonlymphoid Cells Suppress Proliferation of Autoimmune T-Helper Lymphocytes

1987 • 118 citations

Glial retinal Müller cells produce IL-1 activity and have a dual effect on autoimmune T helper lymphocytes. Antigen presentation manifested after removal of suppressive activity.

1988 • 116 citations

Direct cloning and extended culture of antigen-specific MHC-restricted, proliferating T lymphocytes

1980 • 115 citations

Monoclonal Antibodies against ICAM-1 (CD54) and LFA-1 (CD11a/CD18) Inhibit Experimental Autoimmune Uveitis

1993 • 112 citations

Vaccination against autoimmune encephalomyelitis (EAE): Attenuated autoimmune T lymphocytes confer resistance to induction of active EAE but not to EAE mediated by the intact T lymphocyte line

1981 • 108 citations

Amino acid residues that flank core peptide epitopes and the extracellular domains of CD4 modulate differential signaling through the T cell receptor.

1994 • 102 citations

Experimental autoimmune orchitis induced by testis and sperm antigen-specific T cell clones: an important pathogenic cytokine is tumor necrosis factor.

1993 • 94 citations

Retinal Pigment Epithelial Cells Modulate Lymphocyte Function at the Blood-Retina Barrier by Autocrine PGE2 and Membrane-Bound Mechanisms

1993 • 92 citations

Uveitis Induced in Primates by Interphotoreceptor Retinoid-Binding Protein

1986 • 91 citations

Recruitment of antigen-nonspecific cells plays a pivotal role in the pathogenesis of a T cell-mediated organ-specific autoimmune uveoretinitis

1993 • 80 citations

Isolation of encephalitogenic CD4+ T cell clones in the rat

1989 • 78 citations

Interactions between lymphocytes and cells of the blood-retina barrier: mechanisms of T lymphocyte adhesion to human retinal capillary endothelial cells and retinal pigment epithelial cells in vitro.

1990 • 78 citations

A longitudinal study on IL-2, sIL-2R, IL-4 and IFN-γ in multiple sclerosis CSF and serum

1991 • 57 citations

Studies of experimental allergic encephalomyelitis by using encephalitogenic T cell lines and clones in euthymic and athymic mice.

1986 • 53 citations

Regulation of Antibody Production by Helper T Cell Clones in Experimental Autoimmune Myasthenia Gravis Is Mediated by IL-4 and Antigen-Specific T Cell Factors

1993 • 49 citations

Evidence for selective accumulation of V beta 8+ T lymphocytes in experimental autoimmune uveoretinitis induced with two different retinal antigens.

1993 • 38 citations

Induction of experimental autoimmune uveoretinitis by T-cell lines.

1986 • 34 citations

Experimental autoimmune encephalomyelitis mediated by T-cell line

1984 • 31 citations

Activation requirements of donor T cells and host T cell recruitment in adoptive transfer of M urine experimental autoimmune orchitis (EAO)

1989 • 30 citations

Glial cells as suppressor cells: Characterization of the inhibitory function

1989 • 28 citations

Uveitogenic potential of lymphocytes sensitized to interphotoreceptor retinoid-binding protein.

1987 • 27 citations

TH1 and TH2 dependent cytokines in experimental autoimmunity and immune reactions induced by chemicals.

1991 • 27 citations

Predominant usage of Vβ8.3 T cell receptor in a T cell line that induces experimental autoimmune uveoretinitis (EAU)

1992 • 19 citations

Intraocular trafficking of lymphocytes in locally induced experimental autoimmune uveoretinitis (EAU)

1988 • 16 citations

Does CD4 help to maintain the fidelity of T cell receptor specificity?

1992 • 14 citations

Lymphokine production by encephalitogenic and non-encephalitogenic T-cell clones reactive to the same antigenic determinant

1990 • 13 citations

Are accessory molecules implicated in activation of T cells at the blood-retinal barrier?

1990 • 9 citations