Iontophoretic delivery of peptide drugs

The role of electroosmotic flow in transdermal iontophoresis

2001 • 400 citations

Strain effects on amine basicities

1989 • 350 citations

Transdermal drug delivery : developmental issues and research initiatives

1989 • 307 citations

Kinetics of pharmacologic response I. Proposed relationships between response and drug concentration in the intact animal and man

1968 • 303 citations

Prediction of Percutaneous Penetration

1997 • 246 citations

Comparison Between the Lontophoretic and Passive Transport of Thyrotropin Releasing Hormone Across Excised Nude Mouse Skin

1986 • 235 citations

Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase.

1994 • 210 citations

Measurement of glucose in diabetic subjects using noninvasive transdermal extraction

1995 • 184 citations

Convective solvent flow across the skin during iontophoresis.

1993 • 162 citations

Iontophoretic Delivery Model Inorganic and Drug Ions

1989 • 151 citations

Iontophoresis in drug delivery: basic principles and applications.

1994 • 149 citations

Transdermal ion migration

1992 • 140 citations

Effect of electroporation on transdermal iontophoretic delivery of luteinizing hormone releasing hormone (LHRH) in vitro.

1994 • 130 citations

Synthesis and biological activity of some very hydrophobic superagonist analogs of luteinizing hormone-releasing hormone

1982 • 128 citations

The role of electroosmotic flow in transdermal iontophoresis

1992 • 120 citations

Control of Blood Glucose Levels in Alloxan-diabetic Rabbits by Iontophoresis of Insulin

1986 • 113 citations

Direct Current Iontophoretic Transdermal Delivery of Peptide and Protein Drugs

1989 • 110 citations

Characterization of convective solvent flow during iontophoresis.

1994 • 107 citations

Skin alteration and convective solvent flow effects during iontophoresis: I. Neutral solute transport across human skin

1991 • 106 citations

Purification and Preliminary Characterization of Stratum Corneum Chymotryptic Enzyme: A Proteinase That May Be Involved in Desquamation

1993 • 106 citations

Iontophoretic delivery of a series of tripeptides across the skin in vitro.

1991 • 100 citations

Blood glucose control in diabetic rats by transdermal iontophoretic delivery of insulin

1988 • 89 citations

Successful transdermal administration of therapeutic doses of a polypeptide to normal human volunteers

1988 • 87 citations

Hydrogel-based iontotherapeutic delivery devices for transdermal delivery of peptide/protein drugs.

1993 • 85 citations

Transdermal Lontophoresis of Gonadotropin Releasing Hormone (Lhrh) and Two Analogues

1990 • 82 citations

(D) Routes of delivery: Case studies

1992 • 81 citations

Iontophoresis of Polypeptides: Effect of Ethanol Pretreatment of Human Skin

1990 • 79 citations

The Iontophoresis of Fentanyl Citrate in Humans

1995 • 78 citations

Solute molecular size and transdermal iontophoresis across excised human skin

1993 • 77 citations

Iontophoretic enhancement of peptides: behaviour of leuprolide versus model permeants

1994 • 74 citations

Model systems in iontophoresis — transport efficacy

1992 • 68 citations

Facilitated transdermal delivery of therapeutic peptides and proteins by iontophoretic delivery devices

1990 • 67 citations

Studies on the Conducting Properties of the Human Skin to Direct Current

1943 • 64 citations

Pulsatile Drug Delivery: Current Applications and Future Trends

1993 • 63 citations

Iontophoretic transport of a homologous series of ionized and nonionized model compounds: influence of hydrophobicity and mechanistic interpretation.

1989 • 59 citations

Iontophoretic Delivery of Oligonucleotides across full Thickness Hairless Mouse Skin

1995 • 55 citations

In vitro and in vivo iontophoresis of a tripeptide across nude rat skin

1992 • 53 citations

Potential novel methods for insulin administration: I. Iontophoresis.

1984 • 53 citations

A comparison of pulsed and continuous current iontophoresis

1990 • 52 citations

Transdermal lontophoretic Peptide Delivery: In Vitro and In Vivo Studies with Luteinizing Hormone Releasing Hormone

1993 • 50 citations

Iontophoretic delivery of nafarelin across the skin

1995 • 49 citations

Transdermal iontophoretic delivery of arginine-vasopressin (I): Physicochemical considerations

1989 • 47 citations

Effects of Proteolytic Enzyme Inhibitors as Absorption Enhancers on the Transdermal Iontophoretic Delivery of Calcitonin in Rats

1992 • 44 citations

Control of blood glucose levels in alloxan-diabetic rabbits by iontophoresis of insulin

1986 • 43 citations

Transdermal versus subcutaneous leuprolide: A comparison of acute pharmacodynamic effect

1990 • 41 citations

Effect of current magnitude and drug concentration on iontophoretic delivery of octreotide acetate (Sandostatin) in the rabbit.

1994 • 40 citations

Effect of Iontophoresis on In Vitro Skin Permeation of an Analogue of Growth Hormone Releasing Factor in the Hairless Guinea Pig Model

1992 • 38 citations

Transdermal lontophoretic Peptide Delivery: In Vitro and In Vivo Studies with Luteinizing Hormone Releasing Hormone

1993 • 38 citations

Transdermal Delivery of Human Insulin to Albino Rabbits Using Electrical Current

1989 • 36 citations

Baseline studies with the four-electrode system: The effect of skin permeability increase and water transport on the flux of a model uncharged solute during iontophoresis

1989 • 36 citations

Transdermal iontophoretic delivery of arginine-vasopressin (II): Evaluation of electrical and operational factors

1990 • 35 citations

In vivo transdermal iontophoretic delivery of growth hormone releasing factor GRF (1–44) in hairless guinea pigs

1992 • 35 citations

Transdermal iontophoretic delivery of luteinizing hormone releasing hormone (LHRH): effect of repeated administration.

1994 • 34 citations

Human Calcitonin Delivery in Rats by Iontophoresis

1994 • 33 citations

The Effects of Formulation Variables on Iontophoretic Transdermal Delivery of Leuprolide to Humans

1993 • 32 citations

In vitro pulsatile and continuous transdermal delivery of buserelin by iontophoresis

1993 • 30 citations

Transdermal iontophoretic delivery and degradation of vasopressin across human cadaver skin

1995 • 29 citations

A comparison of peptidase activities and peptide metabolism in cultured mouse keratinocytes and neonatal mouse epidermis.

1991 • 28 citations

Comparison of enzymic activities of tissues lining portals of drug absorption, using the rat as a model

1990 • 25 citations

Effects of proteolytic enzyme inhibitors of enhancement of transdermal iontophoretic delivery of vasopressin and an analogue in rats

1992 • 24 citations

Transdermal Iontophoresis

1994 • 20 citations

Mechanisms involved in iontophoretic transport of angiotensin.

1995 • 18 citations

Insulin Iontophoresis in Cystic Fibrosis

1975 • 13 citations

Isoelectric Focusing and Capillary Zone Electrophoretic Studies Using Luteinizing Hormone Releasing Hormone and Its Analog

1994 • 12 citations

Evaluation of a cultured skin equivalent as a model membrane for iontophoretic transport

1994 • 10 citations

Purification and characterization of keratin hydrolase in psoriatic epidermis: Application of keratin-agarose plate and keratin-polyacrylamide enzymography methods

1985 • 9 citations

The electrophoretic mobility of tripeptides as a function of pH and ionic strength: comparison with iontophoretic flux data.

1995 • 8 citations

Iontophoretic Delivery of Morphine for Postoperative Analgesia

1992 • 6 citations