Small interfering RNA-induced suppression of ERCC1 enhances sensitivity of human cancer cells to cisplatin

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

2002 • 1,526 citations

Killing the messenger: short RNAs that silence gene expression

2003 • 1,197 citations

RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

2002 • 1,037 citations

Mechanisms of resistance to cisplatin

2001 • 849 citations

Identification of essential genes in cultured mammalian cells using small interfering RNAs

2001 • 835 citations

Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer.

2002 • 667 citations

Nucleotide excision repair and human syndromes

2000 • 663 citations

RNA-triggered gene silencing

1999 • 623 citations

ERCC1 and Thymidylate Synthase mRNA Levels Predict Survival for Colorectal Cancer Patients Receiving Combination Oxaliplatin and Fluorouracil Chemotherapy

2001 • 608 citations

ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy.

1998 • 512 citations

Cisplatin and DNA repair in cancer chemotherapy

1995 • 506 citations

Messenger RNA levels of XPAC and ERCC1 in ovarian cancer tissue correlate with response to platinum-based chemotherapy.

1994 • 439 citations

Platinum-DNA adduct, nucleotide excision repair and platinum based anti-cancer chemotherapy

1998 • 388 citations

Particular aspects of platinum compounds used at present in cancer treatment

2002 • 367 citations

RNA interference: listening to the sound of silence.

2001 • 365 citations

Molecular characterization of the human excision repair gene : cDNA cloning and amino acid homology with the yeast DNA repair gene

1986 • 330 citations

Enhanced DNA repair as a mechanism of resistance to cis-diamminedichloroplatinum(II)

1988 • 314 citations

Molecular cloning of a human DNA repair gene

1984 • 307 citations

RNA Interference and Small Interfering RNAs

2001 • 299 citations

Damage recognition in nucleotide excision repair of DNA

2000 • 296 citations

Efficient nucleotide excision repair of cisplatin, oxaliplatin, and Bis-aceto-ammine-dichloro-cyclohexylamine-platinum(IV) (JM216) platinum intrastrand DNA diadducts.

1999 • 284 citations

Increased nucleotide excision repair in cisplatin-resistant ovarian cancer cells

2000 • 265 citations

Comparison of two human ovarian carcinoma cell lines (A2780/CP70 and MCAS) that are equally resistant to platinum, but differ at codon 118 of the ERCC1 gene.

2000 • 200 citations

The General Transcription-Repair Factor TFIIH Is Recruited to the Excision Repair Complex by the XPA Protein Independent of the TFIIE Transcription Factor

1995 • 188 citations

DNA repair and cisplatin resistance in non-small-cell lung cancer

2002 • 171 citations

Excision Repair in Mammalian Cells

1995 • 167 citations

Association between the level of ERCC-1 expression and the repair of cisplatin-induced DNA damage in human ovarian cancer cells.

2000 • 158 citations

ERCC1 expression as a molecular marker of cisplatin resistance in human cervical tumor cells

2000 • 143 citations

An intrastrand d(GpG) platinum crosslink in duplex M13 DNA is refractory to repair by human cell extracts.

1992 • 113 citations

Role of carrier ligand in platinum resistance of human carcinoma cell lines.

1993 • 112 citations

DNA repair in cells sensitive and resistant to cis-diamminedichloroplatinum(II): host-cell reactivation of damaged plasmid DNA

1989 • 106 citations

Cisplatin sensitivity/resistance in UV repair-deficient Chinese hamster ovary cells of complementation groups 1 and 3

1993 • 99 citations

Cells from ercc1-deficient mice show increased genome instability and a reduced frequency of s-phase-dependent illegitimate chromosome exchange but a normal frequency of homologous recombination

1998 • 94 citations

Single d(GpG)/cis-Diammineplatinum(II) Adduct-Induced Inhibition of DNA Polymerization

1998 • 68 citations

Oncogenic H-Ras Enhances DNA Repair through the Ras/Phosphatidylinositol 3-Kinase/Rac1 Pathway in NIH3T3 Cells

2002 • 59 citations

Increased gene specific repair of cisplatin induced interstrand crosslinks in cisplatin resistant cell lines, and studies on carrier ligand specificity

1996 • 39 citations

Survival, mutagenesis, and host cell reactivation in a Chinese hamster ovary cell ERCC1 knock-out mutant

1997 • 32 citations

A new approach to the inhibition of gene expression

2002 • 26 citations