Reduction in Water Activity Greatly Retards the Phosphoryl Transfer from ATP to Enzyme Protein in the Catalytic Cycle of Sarcoplasmic Reticulum Ca2+-ATPase

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Enzyme structure and mechanism

1978 • 2,897 citations

The Behavior and Significance of Slow‐Binding Enzyme Inhibitors

1988 • 828 citations

Two Ca2+ ATPase genes: Homologies and mechanistic implications of deduced amino acid sequences

1986 • 812 citations

ADENOSINE TRIPHOSPHATE-LINKED CONCENTRATION OF CALCIUM IONS IN A PARTICULATE FRACTION OF RABBIT MUSCLE

1962 • 701 citations

Enzyme structure and mechanism (2nd edn)

1985 • 484 citations

Reaction Mechanism of the Ca++-dependent ATPase of Sarcoplasmic Reticulum from Skeletal Muscle*

1967 • 331 citations

Identification of a labelled peptide after stoicheiometric reaction of fluorescein isothiocyanate with the Ca²⁺ -dependent adenosine triphosphatase of sarcoplasmic reticulum

1982 • 260 citations

A Borohydride Reduction Method for Characterization of the Acyl Phosphate Linkage in Proteins and Its Application to Sarcoplasmic Reticulum Adenosine Triphosphatase

1973 • 246 citations

Role of water, hydrogen ion, and temperature on the synthesis of adenosine triphosphate by the sarcoplasmic reticulum adenosine triphosphatase in the absence of a calcium ion gradient

1980 • 238 citations

Similarity of the Active Site of Phosphorylation of the Adenosine Triphosphatase for Transport of Sodium and Potassium Ions in Kidney to That for Transport of Calcium Ions in the Sarcoplasmic Reticulum of Muscle

1973 • 206 citations

The predicted secondary structures of the nucleotide‐binding sites of six cation‐transporting ATPases lead to a probable tertiary fold

1989 • 163 citations

Role of water in the energy of hydrolysis of phosphate compounds — energy transduction in biological membranes

1989 • 148 citations

Adenosine deaminase and adenylate deaminase: comparative kinetic studies with transition state and ground state analog inhibitors

1980 • 126 citations

Functional consequences of alterations to amino acids located in the nucleotide binding domain of the Ca2(+)-ATPase of sarcoplasmic reticulum.

1990 • 115 citations

Adenosine triphosphatase site stoichiometry in sarcoplasmic reticulum vesicles and purified enzyme

1984 • 109 citations

A 31‐residue tryptic peptide from the active site of the [Ca⁺⁺]‐transporting adenosine triphosphatase of rabbit sarcoplasmic reticulum

1976 • 95 citations

Evaluation of H₂O activity in the free or phosphorylated catalytic site of Ca²⁺‐ATPase

1983 • 92 citations

ATP synthesis by sarcoplasmic reticulum ATPase following Ca2+, PH, temperature, and water activity jumps.

1982 • 82 citations

2‘,3‘-O-(2,4,6-trinitrophenyl)-8-azido-AMP and -ATP photolabel Lys-492 at the active site of sarcoplasmic reticulum Ca(2+)-ATPase.

1992 • 61 citations

Ca2+-Dependent Conformational Change of the ATP-Binding Site of Ca2+-Transporting ATPase of Sarcoplasmic Reticulum as Revealed by an Alteration of the Target-Site Specificity of Adenosine Tr iphosphopyridoxal1

1989 • 59 citations

Stimulatory and Inhibitory Effects of Dimethyl Sulfoxide and Ethylene Glycol on ATPase Activity and Calcium Transport of Sarcoplasmic Membranes

1977 • 49 citations

Phosphorylation of sarcoplasmic reticulum ATPase by orthophosphate in the absence of Ca2+ gradient. Contribution of water activity to the enthalpy and the entropy changes.

1982 • 49 citations

The stereochemical course of phosphoric residue transfer catalyzed by sarcoplasmic reticulum ATPase.

1981 • 47 citations

Dielectric constant of mixed solvents used for a low temperature biochemistry

1974 • 43 citations

Mechanism of allosteric regulation of the calcium-magnesium ATPase of sarcoplasmic reticulum: studies with 5'-adenylyl methylenediphosphate

1985 • 41 citations

A conformational change of N-iodoacetyl-N'-(5-sulfo-1-naphthyl)ethylenediamine-labeled sarcoplasmic reticulum Ca2+-ATPase upon ATP binding to the catalytic site.

1987 • 41 citations

ATP Formation from ADP and a Phosphorylated Intermediate of Ca2+-Dependent ATPase in Fragmented Sarcoplasmic Reticulum*

1970 • 36 citations

Identification of amino acid residues photolabeled with 8-azidoadenosine 5'-diphosphate in the catalytic site of sarcoplasmic reticulum calcium-ATPase

1993 • 30 citations

Labeling of lysine 492 with pyridoxal 5'-phosphate in the sarcoplasmic reticulum Ca(2+)-ATPase. Lysine 492 residue is located outside the fluorescein 5-isothiocyanate-binding region in or near the ATP binding site.

1993 • 29 citations

The ATP-induced change of tryptophan fluorescence reflects a conformational change upon formation of ADP-sensitive phosphoenzyme in the sarcoplasmic reticulum Ca(2+)-ATPase. Stopped-flow spectrofluorometry and continuous flow-rapid quenching method.

1994 • 26 citations

Interaction of nucleotides and cations with the (Ca2+, Mg2+)-ATPase of sarcoplasmic reticulum as determined by fluorescence changes of bound 1-anilino-8-naphthalenesulfonate.

1983 • 26 citations

Characterization of the substrate-induced conformational change of N-iodoacetyl-N′-(5-sulfo-1-naphthyl)ethylenediamine-labeled sarcoplasmic reticulum Ca2+-ATPase by using different kinds of substrate

1990 • 23 citations

Effects of Divalent Cations Bound to the Catalytic Site on ATP-Induced Conformational Changes in the Sarcoplasmic Reticulum Ca2+-ATPase: Stopped-Flow Analysis of the Fluorescence of N-Acetyl-N'-(5-sulfo-1-naphthyl)ethylenediamine Attached to Cysteine-674

1994 • 17 citations

Cooperative Interaction between Ca2+ and β,γ-Methylene Adenosine Triphosphate in Their Binding to Fragmented Sarcoplasmic Reticulum from Bullfrog Skeletal Muscle1

1986 • 16 citations

3'-O-(5-fluoro-2,4-dinitrophenyl)-ATP exclusively labels Lys-492 at the active site of the sarcoplasmic reticulum Ca(2+)-ATPase.

1994 • 12 citations