Hypocholesterolemic activity of a novel inhibitor of cholesterol absorption, SCH 48461

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES

1957 • 63,238 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

Enzymatic Determination of Total Serum Cholesterol

1974 • 9,182 citations

Lipid extraction of tissues with a low-toxicity solvent

1978 • 2,470 citations

[19] Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

1983 • 1,639 citations

A peroxidase-coupled method for the colorimetric determination of serum triglycerides.

1983 • 1,327 citations

Serum cholesterol response to changes in the diet

1965 • 971 citations

Quantitative isolation and gas–liquid chromatographic analysis of total fecal bile acids

1965 • 891 citations

Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans

1993 • 880 citations

Quantitative isolation and gas–liquid chromatographic analysis of total dietary and fecal neutral steroids

1965 • 760 citations

Goodman and Gilman's the pharmacologic basis of therapeutics

1991 • 586 citations

Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism.

1985 • 519 citations

Serum cholesterol response to changes in the diet

1965 • 498 citations

Interruption of the enterohepatic circulation of bile acids in man: comparative effects of cholestyramine and ileal exclusion on cholesterol metabolism.

1971 • 404 citations

Dietary saturated triacylglycerols suppress hepatic low density lipoprotein receptor activity in the hamster.

1985 • 318 citations

Dietary β-sitosterol as an internal standard to correct for cholesterol losses in sterol balance studies

1968 • 265 citations

Fish oil inhibits development of atherosclerosis in rhesus monkeys.

1987 • 233 citations

2-Azetidinones as Inhibitors of Cholesterol Absorption

1994 • 232 citations

Cholesterol absorption efficiency regulates plasma cholesterol level in the Finnish population

1987 • 196 citations

Role of acyl CoA:cholesterol acyltransferase in cholesterol absorption and its inhibition by 57-118 in the rabbit.

1983 • 185 citations

Polarized secretion of newly synthesized lipoproteins by the Caco-2 human intestinal cell line

1987 • 184 citations

Dietary fiber and blood lipids: treatment of hypercholesterolemia with guar crispbread

1980 • 172 citations

Lipid absorptions passing through the unstirred layers, brush-border membrane, and beyond

1993 • 148 citations

In vivo evidence that the lipid-regulating activity of the ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT.

1993 • 146 citations

Bile acid sequestrants: mechanisms of action on bile acid and cholesterol metabolism

1991 • 145 citations

Pharmacologic consequences of cholesterol absorption inhibition: alteration in cholesterol metabolism and reduction in plasma cholesterol concentration induced by the synthetic saponin beta-tigogenin cellobioside (CP-88818; tiqueside).

1993 • 145 citations

Quantitative aspects of the intestinal absorption and metabolism of cholesterol and β-sitosterol in the rat

1968 • 136 citations

CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption.

1989 • 127 citations

Uptake of cholesterol by small intestinal brush border membrane is protein-mediated

1990 • 126 citations

Chylomicron and chylomicron remnant catabolism

1991 • 123 citations

The Intestinal Absorption of Dietary Cholesterol by Hypercholesterolemic (Type II) and Normocholesterolemic Humans

1974 • 104 citations

A method for the chemical synthesis of 14C-labeled fatty acyl coenzyme A's of high specific activity

1980 • 104 citations

Cholesterol transport function of pancreatic cholesterol esterase: Directed sterol uptake and esterification in enterocytes

1993 • 83 citations

Receptor-like function of heparin in the binding and uptake of neutral lipids.

1988 • 65 citations

Separation of six lipid classes on one thin-layer chromatogram

1974 • 57 citations

Atherosclerosis in nonhuman primates.

1977 • 55 citations

Association of patency of the infarct-related coronary artery with plasma levels of plasminogen activator inhibitor activity in acute myocardial infarction

1992 • 49 citations

Cholesterol absorption and turnover in rhesus monkeys as measured by two methods.

1980 • 48 citations

Atherosclerosis in rhesus and cynomolgus monkeys.

1976 • 46 citations

Acyl-CoA: cholesterol O-acyl transferase (ACAT) inhibitors. 1. 2-(Alkylthio)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT

1992 • 38 citations

Fish oil inhibits development of atherosclerosis in rhesus monkeys

1988 • 35 citations

Effects of acyl-CoA: Cholesterol O-acyltransferase inhibition on cholesterol absorption and plasma lipoprotein composition in hamsters

1991 • 34 citations

High-Molecular-Weight Hydroxypropylmethylcellulose

1993 • 32 citations

Evaluation of Animal Models for the Study of the Pathogenesis of Atherosclerosis

1978 • 29 citations

Demonstration of a direct effect on hepatic acyl CoA:cholesterol acyl transferase (ACAT) activity by an orally administered enzyme inhibitor in the hamster

1994 • 24 citations

International Symposium State of Prevention and Therapy in Human Arteriosclerosis and in Animal Models

1978 • 23 citations

Aspects of cholesterol metabolism in normal and hypercholesterolemic Syrian hamsters. Influence of fenofibrate.

1988 • 17 citations

Cholesterol-lowering drugs as cardioprotective agents

1992 • 17 citations

Lipid lowering actions of 7-(2-methylene butyryl)-(2H)-1,4-benzoxazin-3-(4H)-one derivatives in mice, rats and Syrian hamsters

1989 • 14 citations

Origin and Fate of Cholesterol in Rat Plasma Lipoproteins in vivo

1985 • 11 citations

High-molecular-weight hydroxypropylmethylcellulose. A cholesterol-lowering agent

1993 • 8 citations

Effect of Simvastatin (MK-733) on Sterol and Bile Acid Excretion in Rabbits

1990 • 7 citations

Improved method for the determination of the major neutral steroids and unconjugated bile acids in human faeces using capillary gas chromatography

1987 • 6 citations

Hypocholesterolaemic effect of β β'-methyl-substituted hexadecanedioic acid (MEDICA 16) in the male hamster

1993 • 3 citations