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Non-small cell lung cancer: clinical value of new biological predictors

Data up to Jan 2025

Published1997
Citations75
References115

Total Citations Per Year

Abstract

References (115)

Cancer: Principles and Practice of Oncology.

1991 • 8,402 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

An Immunohistochemical Study

1989 • 1,928 citations

Cancer: Principles and Practice of Oncology

1994 • 1,825 citations

A New International Staging System for Lung Cancer

1986 • 1,652 citations

Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some, neoplasms

1990 • 1,454 citations

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

1986 • 1,226 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

Incidence of local recurrence and second primary tumors in resected stage I lung cancer

1995 • 971 citations

[Cancer of the lung].

1954 • 861 citations

K-rasOncogene Activation as a Prognostic Marker in Adenocarcinoma of the Lung

1990 • 811 citations

Relation of neovascularisation to metastasis of non-small-cell lung cancer

1992 • 780 citations

Prognosis and survival in resected lung carcinoma based on the new international staging system

1988 • 708 citations

bcl-2 Protein in Non-Small-Cell Lung Carcinoma

1993 • 684 citations

Prognostic Factors for Survival in Patients With Inoperable Lung Cancer<xref ref-type="fn" rid="FN2">2</xref>

1980 • 569 citations

Mutational Activation of the K-rasOncogene

1987 • 542 citations

The prognostic significance of tumor vascularity in intermediate-thickness (0.76-4.0 mm thick) skin melanoma. A quantitative histologic study.

1988 • 538 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

1990 • 515 citations

Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.

1988 • 458 citations

P53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features

1992 • 448 citations

p185neu expression in human lung adenocarcinomas predicts shortened survival.

1990 • 440 citations

Percutaneous etharrol injection in the treatment of hepatocellular carcinoma in cirrhosis. A study on 207 patients

1992 • 408 citations

Prognostic factors for survival in advanced non-small-cell lung cancer: univariate and multivariate analyses including recursive partitioning and amalgamation algorithms in 1,052 patients. The European Lung Cancer Working Party.

1995 • 396 citations

Postsurgical Stage I Bronchogenic Carcinoma: Morbid Implications of Recurrent Disease

1984 • 386 citations

Accumulation of p53 protein correlates with a poor prognosis in human lung cancer.

1992 • 384 citations

Survival in early-stage non-small cell lung cancer

1995 • 372 citations

Clinical significance of ras oncogene activation in human lung cancer

1993 • 361 citations

Prognostic significance of p53 mutations and 3p deletions in primary, resected non-small cell lung cancer

1995 • 333 citations

Stage I nonsmall cell lung cancer. A multivariate analysis of treatment methods and patterns of recurrence

1995 • 323 citations

Commentary from Westminster

1984 • 309 citations

A prognostic model of recurrence and death in stage I non-small cell lung cancer utilizing presentation, histopathology, and oncoprotein expression.

1995 • 300 citations

Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines

1992 • 298 citations

Prognostic factors in patients with resected stage I non-small cell lung cancer. A report from the Lung Cancer Study Group

1984 • 279 citations

Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation

1993 • 275 citations

Implications of the p53 tumor-suppressor gene in clinical oncology.

1995 • 258 citations

ras gene mutations in non-small cell lung cancers are associated with shortened survival irrespective of treatment intent.

1991 • 249 citations

Correlation of Expression of H/LeY/LeBAntigens with Survival in Patients with Carcinoma of the Lung

1992 • 235 citations

Expression of the neu gene-encoded protein (P185neu) in human non-small cell carcinomas of the lung.

1990 • 232 citations

Expression of Blood-Group Antigen A — A Favorable Prognostic Factor in Non-Small-Cell Lung Cancer

1991 • 221 citations

New aspects in the staging of lung cancer. Prospective validation of the international union against cancer TNM classification

1992 • 210 citations

Bcl-2 protein: a prognostic factor inversely correlated to p53 in non-small-cell lung cancer

1995 • 201 citations

The p53 gene is very frequently mutated in small-cell lung cancer with a distinct nucleotide substitution pattern

1992 • 199 citations

Prognostic value of c-erbB-2 protein expression in human lung adenocarcinoma and squamous cell carcinoma

1991 • 185 citations

Microvessel count predicts metastatic disease and survival in non‐small cell lung cancer

1995 • 184 citations

C-erbB-2 expression and codon 12 K-ras mutations both predict shortened survival for patients with pulmonary adenocarcinomas.

1994 • 182 citations

Aberrations of the p53 tumor suppressor gene in human non-small cell carcinomas of the lung

1993 • 180 citations

PLOIDY AS A PROGNOSTIC DETERMINANT IN SURGICALLY TREATED LUNG CANCER

1987 • 174 citations

Immunohistochemical evidence of autocrine growth factors in adenocarcinoma of the human lung.

1990 • 174 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer

1991 • 173 citations

Correlation of Intrinsic Chemoresistance of Non-Small-Cell Lung Cancer Cell Lines With HER-2/neu Gene Expression but Not With ras Gene Mutations

1993 • 170 citations

ras gene mutations as a prognostic marker in adenocarcinoma of the human lung without lymph node metastasis.

1992 • 168 citations

Detection of K-ras mutations in lung carcinomas: Relationship to prognosis

1996 • 166 citations

Histopathologic prognostic factors in adenocarcinomas of the peripheral lung less than 2 CM in diameter

1988 • 161 citations

Expression of p53 oncoprotein in non-small-cell lung cancer: a favorable prognostic factor.

1995 • 160 citations

The relationship of p53 immunostaining to survival in carcinoma of the lung

1992 • 147 citations

The biology of lung cancer.

1993 • 143 citations

A, B, H antigens in transitional cell tumors of the urinary bladder.Correlation with the clinical course

1979 • 141 citations

Five-year follow-up study of independent clinical and flow cytometric prognostic factors for the survival of patients with non-small cell lung carcinoma.

1988 • 141 citations

Molecular and pathologic markers in stage I non-small-cell carcinoma of the lung.

1995 • 141 citations

Relationship of p53 overexpression and up-regulation of proliferating cell nuclear antigen with the clinical course of non-small cell lung cancer.

1994 • 139 citations

Altered Retinoblastoma Protein Expression and Prognosis in Early-Stage Non-Small-Cell Lung Carcinoma

1994 • 130 citations

Prognosis in carcinoma of the urinary bladder based upon tissue blood group abh and Thomsen-Friedenreich antigen status and karyotype of the initial tumor.

1983 • 125 citations

Blood vessel invasion by tumor cells predicts recurrence in completely resected T1 N0 M0 non-small-cell lung cancer

1993 • 119 citations

p53 Immunostaining Positivity Is Associated With Reduced Survival and Is Imperfectly Correlated With Gene Mutations in Resected Non-small Cell Lung Cancer

1994 • 118 citations

Prognostic factors in surgically resected limited-stage, nonsmall cell carcinoma of the lung

1984 • 116 citations

A and B Antigens of Tumors Arising From Urinary Epithelium

1961 • 101 citations

Prognostic significance of the expression ofras oncogene product in non-small cell lung cancer

1992 • 98 citations

Nonanatomic prognostic factors in carcinoma of the lung. A multivariate analysis

1982 • 96 citations

Prognostic significance of Ki67 labelling in resected non small cell lung cancer

1993 • 93 citations

Postoperative T1 N0 non-small cell lung cancer

1987 • 93 citations

Accumulation of a blood group antigen precursor in oral premalignant lesions.

1983 • 92 citations

Prognostic and therapeutic significance of the flow cytometric nuclear DNA content in non-small cell lung cancer

1990 • 91 citations

Angiogenesis: An indicator of metastasis in non-small cell lung cancer invading the thoracic inlet

1994 • 90 citations

Ki‐67 immunostaining and survival in operable lung cancer

1991 • 88 citations

The expression of proliferating cell nuclear antigen in paraffin sections of peripheral, node-negative non-small cell lung cancer

1992 • 88 citations

Is T factor of the TNM staging system a predominant prognostic factor in pathologic stage I non-small-cell lung cancer ? A multivariate prognostic factor analysis of 151 patients.

1993 • 82 citations

Comparative analysis of p53 gene mutations and protein accumulation in human non‐small‐cell lung cancer

1995 • 81 citations

The effect of tumor size and tumor cell DNA content on the survival of patients with stage I adenocarcinoma of the lung

1989 • 79 citations

Impact of Neuroendocrine Differentiation in Non-small Cell Lung Cancer

1994 • 79 citations

Prognostic significance of the expression of c-fos, c-jun and c-erbB-1 oncogene products in human squamous cell lung carcinomas

1993 • 76 citations

The prognostic significance of neuroendocrine markers and carcinoembryonic antigen in patients with resected stage I and II non-small cell lung cancer.

1994 • 76 citations

Immunohistochemical detection of p53 protein is not associated with a poor prognosis in non-small-cell lung cancer

1995 • 70 citations

Flow cytometric analysis of DNA ploidy level in paraffin-embedded tissue of non-small-cell lung cancer

1988 • 67 citations

Is T factor of the TNM staging system a predominant prognostic factor in pathologic stage I non-small-cell lung cancer?

1993 • 67 citations

Flow cytometric analysis of the DNA content of non-small cell lung cancer ploidy as a significant prognostic indicator in squamous cell carcinoma of the lung

1990 • 66 citations

Proliferating cell nuclear antigen expression and argyrophilic nucleolar organizer regions as factors influencing prognosis of surgically treated lung cancer patients.

1993 • 65 citations

The histopathological evaluation of nucleolar organizer region proteins

1988 • 64 citations

Prognostic factors in resected stages I and II adenocarcinoma of the lung

1990 • 58 citations

Clinicopathological Significance of Nuclear Accumulation of Tumor Suppressor Gene p53 Product in Primary Lung Cancer

1992 • 57 citations

Prognostic value of nuclear DNA content and expression of the ras oncogene product in lung cancer.

1991 • 57 citations

The percentage of aneuploid cells is significantly correlated with survival in accurately staged patients with stage 1 resected squamous cell lung cancer and long-term follow up

1989 • 54 citations

Vascular invasion in non-small cell lung carcinoma.

1992 • 49 citations

Biological consequences of overexpression of a transfected c-erbB-2 gene in immortalized human bronchial epithelial cells.

1993 • 48 citations

Blood group antigen A and flow cytometric analysis in resected early-stage non-small cell lung cancer.

1997 • 47 citations

A flow cytometric study of non-small cell lung cancer classified as T1N0

1992 • 47 citations

p53 immunostaining positivity is associated with reduced survival and is imperfectly correlated with gene mutations in resected non-small cell lung cancer. A preliminary report of LCSG 871

1994 • 41 citations

Expression of Lewis-related antigen and prognosis in stage I non—small cell lung cancer

1995 • 39 citations

Expression of bcl-2 protein in stage T1NOMO non-small cell lung carcinoma

1995 • 39 citations

p53: from molecular mechanisms to prognosis in cancer.

1995 • 38 citations

DNA analysis by flow cytometry in nonsmall cell lung cancer: relationship to epidermal growth factor receptor, histology, tumour stage and survival

1990 • 37 citations

Prognostic Significance of Tumor Proliferative Fraction and DNA Content in Stage I Non-Small Cell Lung Cancer

1992 • 36 citations

Impact of neuroendocrine differentiation in non-small cell lung cancer. The LCSG experience

1994 • 36 citations

Prognostic significance of parenchymal lymphatic vessel and blood vessel invasion in carcinoma of the lung.

1983 • 34 citations

Prognostic significance of flow cytometry in non-small-cell lung cancer

1993 • 34 citations

Blood group abh‐related antigens in normal and malignant bladder urothelium: Possible structural basis for the deletion of type‐2 chain abh antigens in invasive carcinomas

1989 • 31 citations

Immunostains for blood group antigens lack prognostic significance in T1 lung carcinoma

1995 • 28 citations

Prognostic implications of histopathologic subtyping in patients with surgically treated stage I or II adenocarcinoma of the lung

1989 • 27 citations

[Results of surgical treatment of stage I lung cancer].

1993 • 24 citations

Mutated K-ras gene analysis in a randomized trial of preoperative chemotherapy plus surgery versus surgery in Stage IIIA non-small cell lung cancer

1995 • 23 citations

Expression of blood group antigen A by stage I non-small cell lung carcinomas

1995 • 14 citations

DNA polymerase-α as a putative early relapse marker in non-small cell lung cancer. An immunohistochemical study

1991 • 13 citations

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Non-small cell lung cancer: clinical value of new biological predictors (1997) – Lung Cancer | Metascience Observatory Explorer