The epidemiology of vitamin D and cancer incidence and mortality: A review (United States)

Akufo and Ibarapa

1965 • 16,925 citations

Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

2003 • 7,305 citations

Decreased bioavailability of vitamin D in obesity

2000 • 3,081 citations

Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices

1975 • 2,207 citations

Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis

2004 • 1,664 citations

INCREASED SKIN PIGMENT REDUCES THE CAPACITY OF SKIN TO SYNTHESISE VITAMIN D3

1982 • 1,154 citations

Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988–1994,

2002 • 1,010 citations

Do Sunlight and Vitamin D Reduce the Likelihood of Colon Cancer?

1980 • 879 citations

Calcium Supplements for the Prevention of Colorectal Adenomas

1999 • 853 citations

An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet‐B radiation

2002 • 765 citations

DIETARY VITAMIN D AND CALCIUM AND RISK OF COLORECTAL CANCER: A 19-YEAR PROSPECTIVE STUDY IN MEN

1985 • 725 citations

The Relationship between Obesity and Serum 1,25-Dihydroxy Vitamin D Concentrations in Healthy Adults

2004 • 666 citations

SERUM 25-HYDROXYVITAMIN D AND COLON CANCER: EIGHT-YEAR PROSPECTIVE STUDY

1989 • 665 citations

Cohort study of diet, lifestyle, and prostate cancer in adventist men

1989 • 661 citations

Geographic patterns of prostate cancer mortality. Evidence for a protective effect of ultraviolet radiation

1992 • 657 citations

Geographic variation in breast cancer mortality in the United States: A hypothesis involving exposure to solar radiation

1990 • 579 citations

Colon Cancer and Dietary Fat, Phosphate, and Calcium: A Hypothesis

1984 • 547 citations

Is vitamin D deficiency a risk factor for prostate cancer? (Hypothesis).

1990 • 514 citations

Dairy Foods, Calcium, and Colorectal Cancer: A Pooled Analysis of 10 Cohort Studies

2004 • 513 citations

Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland).

2000 • 489 citations

Vitamin A Intake and Hip Fractures Among Postmenopausal Women

2002 • 460 citations

International comparisons of mortality rates for cancer of the breast, ovary, prostate, and colon, and per capita food consumption

1986 • 456 citations

Determination of vitamin D status by radioimmunoassay with an 125I-labeled tracer

1993 • 439 citations

Plasma Vitamin D Metabolites and Risk of Colorectal Cancer in Women

2004 • 423 citations

Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: A longitudinal, nested case‐control study in the Nordic countries

2003 • 422 citations

Excessive Dietary Intake of Vitamin A Is Associated with Reduced Bone Mineral Density and Increased Risk for Hip Fracture

1998 • 398 citations

Intake of Dairy Products, Calcium, and Vitamin D and Risk of Breast Cancer

2002 • 397 citations

Impact of Obesity on Biochemical Control After Radical Prostatectomy for Clinically Localized Prostate Cancer: A Report by the Shared Equal Access Regional Cancer Hospital Database Study Group

2003 • 387 citations

The Effect of Vitamin D Supplementation on Vitamin D Status and Parathyroid Function in Elderly Subjects*

1988 • 386 citations

Vitamin D, Calcium Supplementation, and Colorectal Adenomas: Results of a Randomized Trial

2003 • 375 citations

Serum Retinol Levels and the Risk of Fracture

2003 • 368 citations

Calcium Intake and Risk of Colon Cancer in Women and Men

2002 • 363 citations

Calcium and fructose intake in relation to risk of prostate cancer.

1998 • 362 citations

Diet, tobacco use, and fatal prostate cancer: results from the Lutheran Brotherhood Cohort Study.

1990 • 362 citations

Vitamin D and prostate cancer: a prediagnostic study with stored sera.

1993 • 357 citations

Animal Fat Consumption and Prostate Cancer

1994 • 348 citations

DIET, OBESITY, AND RISK OF FATAL PROSTATE CANCER1

1984 • 347 citations

Regulation of the metabolism of vitamin D.

1980 • 341 citations

Vitamin D and breast cancer risk: the NHANES I Epidemiologic follow-up study, 1971-1975 to 1992. National Health and Nutrition Examination Survey.

1999 • 333 citations

Diet and risk of colorectal cancer in a cohort of Finnish men.

1999 • 332 citations

Diet and colon cancer in Los Angeles County, California

1992 • 332 citations

Sunlight and mortality from breast, ovarian, colon, prostate, and non-melanoma skin cancer: a composite death certificate based case-control study

2002 • 325 citations

Body mass index, height, and prostate cancer mortality in two large cohorts of adult men in the United States.

2001 • 320 citations

Influence of body mass index on outcomes and treatment‐related toxicity in patients with colon carcinoma

2003 • 304 citations

Vitamin D₃from sunlight may improve the prognosis of breast-, colon- and prostate cancer (Norway)

2004 • 297 citations

Dietary factors and risks for prostate cancer among blacks and whites in the United States.

1999 • 282 citations

Nutritional factors in colorectal cancer risk: A case‐control study in majorca

1991 • 281 citations

Relation of Calcium, Vitamin D, and Dairy Food Intake to Incidence of Colon Cancer among Older Women

1993 • 279 citations

Plant Foods, Antioxidants, and Prostate Cancer Risk: Findings From Case-Control Studies in Canada

1999 • 278 citations

Sunlight, Vitamin D, and Ovarian Cancer Mortality Rates in US Women

1994 • 269 citations

Calcium, Vitamin D, and the Occurrence of Colorectal Cancer Among Women

1996 • 263 citations

Calcium, vitamin D, dairy products, and risk of colorectal cancer in the Cancer Prevention Study II Nutrition Cohort (United States).

2003 • 261 citations

Dairy products, calcium, and prostate cancer risk in the Physicians’ Health Study

2001 • 261 citations

Weekly High-Dose Calcitriol and Docetaxel in Metastatic Androgen-Independent Prostate Cancer

2002 • 257 citations

Trends in cancer incidence: Causes and practical implications

1983 • 242 citations

Vitamin D status in the elderly: seasonal substrate deficiency causes 1,25-dihydroxycholecalciferol deficiency

1987 • 240 citations

Plasma 1,25-Dihydroxy- and 25-Hydroxyvitamin D and Subsequent Risk of Prostate Cancer

2004 • 230 citations

25-Hydroxyvitamin D3-1α-hydroxylase and vitamin D receptor gene expression in human colonic mucosa is elevated during early cancerogenesis

2001 • 226 citations

The human prostatic carcinoma cell line LNCaP expresses biologically active, specific receptors for 1 alpha,25-dihydroxyvitamin D3.

1992 • 226 citations

Body mass index, height, and postmenopausal breast cancer mortality in a prospective cohort of US women.

2002 • 224 citations

Vitamin D receptor gene polymorphisms in relation to Vitamin D related disease states

2004 • 221 citations

Retinol Intake and Bone Mineral Density in the Elderly: The Rancho Bernardo Study

2002 • 221 citations

Calcium, Vitamin D, and Dairy Foods and the Occurrence of Colon Cancer in Men

1996 • 220 citations

The Relation of Solar Radiation to Cancer Mortality in North America

1941 • 218 citations

Selected micronutrient intake and the risk of colorectal cancer

1994 • 217 citations

Reduced 1alpha-hydroxylase activity in human prostate cancer cells correlates with decreased susceptibility to 25-hydroxyvitamin D3-induced growth inhibition.

2001 • 216 citations

A prospective study on intake of animal products and risk of prostate cancer.

2001 • 215 citations

Calcium, vitamin D, sunshine exposure, dairy products and colon cancer risk (United States).

2000 • 214 citations

Serum levels of vitamin D metabolites and the subsequent risk of colon and rectal cancer in Finnish men.

1997 • 214 citations

Cellular Mechanisms of Calcium and Vitamin D in the Inhibition of Colorectal Carcinogenesis

2001 • 212 citations

Beta-carotene and animal fats and their relationship to prostate cancer risk. A case—control study

1989 • 207 citations

Dietary fat intake and risk of prostate cancer: A prospective study of 25,708 Norwegian men

1997 • 207 citations

Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer (Sweden)

1998 • 201 citations

TREATMENT OF EARLY RECURRENT PROSTATE CANCER WITH 1,25-DIHYDROXYVITAMIN D3 (CALCITRIOL)

1998 • 200 citations

Dairy products and colorectal cancer. A review of possible mechanisms and epidemiological evidence

2003 • 196 citations

Dietary influences of 1,25(OH)2 vitamin D in relation to prostate cancer: a hypothesis.

1998 • 195 citations

Nutrition, social factors and prostatic cancer in a Northern Italian population

1986 • 189 citations

Circulating vitamin D metabolites in relation to subsequent development of prostate cancer.

1996 • 181 citations

Animal products, calcium and protein and prostate cancer risk in the Netherlands Cohort Study

1999 • 179 citations

Diet and cancer of the prostate: a case-control study in Greece

1999 • 177 citations

Vitamin D, calcium, and vitamin D receptor polymorphism in colorectal adenomas.

2001 • 174 citations

Inhibition of prostate cancer metastasis in vivo: a comparison of 1,23-dihydroxyvitamin D (calcitriol) and EB1089.

1999 • 174 citations

An investigation of sources of variation in calcium absorption efficiency.

1995 • 172 citations

Vitamin A Antagonizes Calcium Response to Vitamin D in Man

2001 • 166 citations

Serum vitamin D metabolite levels and the subsequent development of prostate cancer (Hawaii, United States)

1998 • 165 citations

Calcium, dairy products, and risk of prostate cancer in a prospective cohort of United States men.

2003 • 164 citations

Associations of energy, fat, calcium, and vitamin D with prostate cancer risk.

2002 • 160 citations

Ecologic Studies of Solar UV-B Radiation and Cancer Mortality Rates

2003 • 159 citations

Calcium, phosphorus, vitamin D, dairy products and colorectal carcinogenesis: a French case - control study

1996 • 158 citations

Diet and prostatic cancer: A case‐control study in northern Italy

1992 • 158 citations

Foods, nutrients and prostate cancer: a case–control study in Uruguay

1999 • 154 citations

A case-control study of cancer of the prostate in Somerset and east Devon

1996 • 150 citations

Vitamin A Antagonizes the Action of Vitamin D in Rats

1999 • 145 citations

Colon Cancer and Serum Vitamin D Metabolite Levels 10–17 Years prior to Diagnosis

1995 • 141 citations

Prostatic 25‐hydroxyvitamin D‐1α‐hydroxylase and its implication in prostate cancer

2003 • 139 citations

1,25-dihydroxy-16-ene-23-yne-vitamin d3 and prostate cancer cell proliferation in vivo

1995 • 134 citations

Studies in the epidemiology of prostatic cancer: expanded sampling.

1977 • 133 citations

The Effects of Oral CaCO₃Loading and Dietary Calcium Deprivation on Plasma 1,25-Dihydroxyvitamin D Concentrations in Healthy Adults*

1979 • 131 citations

Reviews: A Critical Review of Studies on Vitamin D in Relation to Colorectal Cancer

2004 • 130 citations

Prospective study on milk products, calcium and cancers of the colon and rectum

2001 • 128 citations

Diet and prostate cancer risk in a cohort of smokers, with a specific focus on calcium and phosphorus (Finland).

2000 • 126 citations

Plasma 1,25-dihydroxy- and 25-hydroxyvitamin D and adenomatous polyps of the distal colorectum.

2000 • 125 citations

Characterization of the vitamin D receptor from the Caco-2 human colon carcinoma cell line: Effect of cellular differentiation

1991 • 124 citations

A prospective cohort study of intake of calcium, vitamin D, and other micronutrients in relation to incidence of rectal cancer among postmenopausal women.

1998 • 117 citations

The association of calcium and vitamin D, and colon and rectal cancer in Wisconsin women

1998 • 112 citations

25-Hydroxyvitamin D-1α-hydroxylase activity is diminished in human prostate cancer cells and is enhanced by gene transfer

2002 • 111 citations

Milk Consumption Is a Risk Factor for Prostate Cancer: Meta-Analysis of Case-Control Studies

2004 • 104 citations

The combination of a potent vitamin D3 analog, EB 1089, with ionizing radiation reduces tumor growth and induces apoptosis of MCF-7 breast tumor xenografts in nude mice.

2003 • 101 citations

Dietary calcium, vitamin D, and the risk of colorectal cancer in Stockholm, Sweden.

1996 • 101 citations

Plasma levels of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and the risk of prostate cancer

2004 • 100 citations

Chemopreventive activity of tamoxifen, N-(4-hydroxyphenyl)retinamide, and the vitamin D analogue Ro24-5531 for androgen-promoted carcinomas of the rat seminal vesicle and prostate.

1995 • 97 citations

Circulating Vitamin D Metabolites, Polymorphism in Vitamin D Receptor, and Colorectal Adenoma Risk

2004 • 94 citations

Sex steroid and 1,25-dihydroxyvitamin D3 receptors in human colorectal adenocarcinoma and normal mucosa.

1991 • 94 citations

Regulation of vitamin D receptor abundance and responsiveness during differentiation of HT-29 human colon cancer cells.

1993 • 93 citations

The role of vitamin D in normal prostate growth and differentiation.

1996 • 90 citations

Serum 25-Hydroxyvitamin D, Dietary Calcium Intake, and Distal Colorectal Adenoma Risk

2001 • 87 citations

SKIN IRRITATION AND CANCER IN THE U. S. NAVY

1937 • 85 citations

The prostate 25-hydroxyvitamin D-1 -hydroxylase is not influenced by parathyroid hormone and calcium: implications for prostate cancer chemoprevention by vitamin D

2004 • 83 citations

Early Onset of Breast Carcinoma in African American Women With Poor Prognostic Factors

1999 • 79 citations

1,25-Dihydroxyvitamin D3 receptors in normal and malignant human colorectal tissues

1994 • 77 citations

Geographic Variation in Breast Cancer Incidence Rates in a Cohort of U.S. Women

1997 • 76 citations

INHIBITION OF TUMOR GROWTH AND ANGIOGENESIS BY VITAMIN D3 AGENTS IN MURINE RENAL CELL CARCINOMA

1998 • 75 citations

1α,25-Dihydroxyvitamin D3 inhibits in vitro invasiveness through the extracellular matrix and in vivo pulmonary metastasis of B16 mouse melanoma

1999 • 75 citations

An investigation of sources of variation in calcium absorption efficiency [published erratum appears in J Clin Endocrinol Metab 1995 Jul;80(7):2068]

1995 • 74 citations

Treating tumor-bearing mice with vitamin D3 diminishes tumor-induced myelopoiesis and associated immunosuppression, and reduces tumor metastasis and recurrence

1995 • 72 citations

An ecologic study of dietary links to prostate cancer.

1999 • 67 citations

Phase II study of 1alpha-hydroxyvitamin D(2) in the treatment of advanced androgen-independent prostate cancer.

2003 • 65 citations

Low 1,25-Dihydroxyvitamin D, Secondary Hyperparathyroidism, and Normal Osteocalcinin Elderly Subjects

1986 • 64 citations

Calcium intake and prostate cancer risk in a long-term aging study: the Baltimore Longitudinal Study of Aging

2002 • 62 citations

Dairy Products and the Risk of Prostatic Cancer

1991 • 61 citations

Tobacco, Alcohol, Diet and Risk of prostate Cancer

1995 • 51 citations

1,25-dihydroxyvitamin D3 synthetic analogs inhibit spontaneous metastases in a 1,2-dimethylhydrazine-induced colon carcinogenesis model.

2000 • 50 citations

The antineoplastic effect of vitamin D in transgenic mice with retinoblastoma.

1992 • 47 citations

Mechanisms of decreased Vitamin D 1α-hydroxylase activity in prostate cancer cells

2004 • 46 citations

Calcium, dairy products, and the risk of prostate cancer

2001 • 42 citations

Age-dependent vitamin D status and vertebral condition of white women living in Curaçao (The Netherlands Antilles) as compared with their counterparts in The Netherlands

1993 • 41 citations

Metastatic growth of lung cancer cells is extremely reduced in Vitamin D receptor knockout mice

2004 • 34 citations

Inhibition of tumor production of granulocyte-macrophage colony-stimulating factor by 1 alpha, 25-dihydroxyvitamin D3 reduces tumor motility and metastasis.

1993 • 33 citations

Seasonal Variation in 25-Hydroxyvitamin D and Parathyroid Hormone Concentrations in Healthy Elderly People

1994 • 24 citations

Vitamin D3 and ceramide reduce the invasion of tumor cells through extracellular matrix components by elevating protein phosphatase-2A.

1996 • 20 citations

Inhibitory effects of 22-oxa-calcitriol and all- trans retinoic acid on the growth of a canine osteosarcoma derived cell-line in vivo and its pulmonary metastasis in vivo

2000 • 15 citations

Nutrition, social factors and prostatic cancer in a northern Italian population

1986 • 8 citations

Deleted Work

1955 • 0 citations