Dairy products and colorectal cancer. A review of possible mechanisms and epidemiological evidence

Meta-analysis in clinical trials

1986 • 36,193 citations

Akufo and Ibarapa

1965 • 16,925 citations

Food, nutrition and the prevention of cancer : a global perspective

1997 • 1,892 citations

Calcium Supplements for the Prevention of Colorectal Adenomas

1999 • 853 citations

Insulin and colon cancer

1995 • 815 citations

DIETARY VITAMIN D AND CALCIUM AND RISK OF COLORECTAL CANCER: A 19-YEAR PROSPECTIVE STUDY IN MEN

1985 • 725 citations

Folate, Methionine, and Alcohol Intake and Risk of Colorectal Adenoma

1993 • 712 citations

SERUM 25-HYDROXYVITAMIN D AND COLON CANCER: EIGHT-YEAR PROSPECTIVE STUDY

1989 • 665 citations

Serum C-Peptide, Insulin-Like Growth Factor (IGF)-I, IGF-Binding Proteins, and Colorectal Cancer Risk in Women

2000 • 653 citations

McCollum Award Lecture, 1994: Vitamin D—new horizons for the 21st century

1994 • 641 citations

Colon Cancer and Dietary Fat, Phosphate, and Calcium: A Hypothesis

1984 • 547 citations

Increased Blood Glucose and Insulin, Body Size, and Incident Colorectal Cancer

1999 • 496 citations

Sugar, meat, and fat intake, and non-dietary risk factors for colon cancer incidence in Iowa women (United States)

1994 • 496 citations

Cows' Milk Fat Components as Potential Anticarcinogenic Agents

1997 • 484 citations

Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk?

1994 • 480 citations

Effect of Added Dietary Calcium on Colonic Epithelial-Cell Proliferation in Subjects at High Risk for Familial Colonic Cancer

1985 • 479 citations

Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial

2000 • 478 citations

Conjugated Linoleic Acid and Other Anticarcinogenic Agents of Bovine Milk Fat

1999 • 427 citations

Prospective Study of Adult Onset Diabetes Mellitus (Type 2) and Risk of Colorectal Cancer in Women

1999 • 426 citations

Apoptosis in colorectal tumour cells: Induction by the short chain fatty acids butyrate, propionate and acetate and by the bile salt deoxycholate

1995 • 411 citations

Risk Factors for Fatal Colon Cancer in a Large Prospective Study

1992 • 397 citations

Immunologic effects of yogurt

2000 • 340 citations

Case‐control study of dietary etiological factors: The Melbourne colorectal cancer study

1987 • 338 citations

Diet and colon cancer in Los Angeles County, California

1992 • 332 citations

Diet and risk of colorectal cancer in a cohort of Finnish men.

1999 • 332 citations

Dietary habits and gastro-intestinal cancers : a comparative case-control study of stomach and large intestinal cancers in Nagoya, Japan

1986 • 322 citations

Dietary Risk Factors for Colon Cancer in a Low-risk Population

1998 • 313 citations

Survey of the Conjugated Linoleic Acid Contents of Dairy Products

1995 • 312 citations

Diet and colorectal cancer: A case‐control study in Greece

1983 • 307 citations

Folate Intake and Carcinogenesis of the Colon and Rectum

1991 • 293 citations

Protection of conjugated linoleic acids against 2-amino-3-methylimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms

1995 • 289 citations

Colorectal Cancer: Another Complication of Diabetes Mellitus?

1998 • 275 citations

Case‐control study on colorectal cancer and diet in marseilles

1986 • 274 citations

Prospective study of diet and female colorectal cancer: The New York university women's health study

1997 • 270 citations

A population‐based case‐control study of colorectal cancer in majorca. I. Dietary factors

1990 • 265 citations

Calcium, Vitamin D, and the Occurrence of Colorectal Cancer Among Women

1996 • 263 citations

Conjugated linoleic acid. A powerful anticarcinogen from animal fat sources

1994 • 262 citations

Food items and food groups as risk factors in a case‐control study of diet and colo‐rectal cancer

1983 • 250 citations

Possible mechanisms relating diet and risk of colon cancer.

2000 • 241 citations

Dietary Relationships With Fatal Colorectal Cancer Among Seventh-Day Adventists<xref ref-type="fn" rid="FN2">2</xref>

1985 • 237 citations

Case‐control study of proximal and distal colon cancer and diet in Wisconsin

1988 • 232 citations

Predictive value of proliferation, differentiation and apoptosis as intermediate markers for colon tumorigenesis

1997 • 230 citations

Vitamin D receptor expression, 24-hydroxylase activity, and inhibition of growth by 1alpha,25-dihydroxyvitamin D3 in seven human prostatic carcinoma cell lines.

1995 • 229 citations

Colorectal cancer and diet in an asian population—A case‐control study among Singapore Chinese

1989 • 222 citations

Calcium, Vitamin D, and Dairy Foods and the Occurrence of Colon Cancer in Men

1996 • 220 citations

Food groups and colorectal cancer risk

1999 • 218 citations

Conjugated linoleic acid

2000 • 217 citations

Calcium, vitamin D, sunshine exposure, dairy products and colon cancer risk (United States).

2000 • 214 citations

A case‐control study of diet and colo‐rectal cancer in Northern Italy

1988 • 213 citations

Colorectal cancer and the consumption of foods: A case‐control study in Belgium

1988 • 211 citations

A case-control study of occupational and dietary factors in colorectal cancer in young men by subsite.

1989 • 210 citations

Calcium, vitamin D, and colorectal cancer: a review of the epidemiologic evidence.

1998 • 206 citations

Evaluation of a biological marker of dairy fat intake

1998 • 203 citations

Human lactoferrin inhibits growth of solid tumors and development of experimental metastases in mice.

1994 • 199 citations

Study of the Possible Mechanisms Involved in the Mucosal Immune System Activation by Lactic Acid Bacteria

1999 • 197 citations

Risk factors for colorectal cancer in a prospective study among U.S. white men

1998 • 196 citations

Dietary influences of 1,25(OH)2 vitamin D in relation to prostate cancer: a hypothesis.

1998 • 195 citations

Bovine Lactoferrin and Lactoferricin, a Peptide Derived from Bovine Lactoferrin, Inhibit Tumor Metastasis in Mice

1997 • 190 citations

Food groups and risk of colorectal cancer in Italy

1997 • 186 citations

Inhibition of human colonic epithelial cell proliferation in vivo and in vitro by calcium.

1986 • 185 citations

Food consumption and cancer of the colon and rectum in north‐eastern Italy

1992 • 172 citations

1,25-Dihydroxyvitamin D3 receptor as a marker of human colon carcinoma cell line differentiation and growth inhibition.

1993 • 172 citations

Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors

1997 • 160 citations

Calcium, phosphorus, vitamin D, dairy products and colorectal carcinogenesis: a French case - control study

1996 • 158 citations

Fermented dairy products, calcium, and colorectal cancer in The Netherlands Cohort Study.

1994 • 158 citations

The role of fat, fatty acids, and total energy intake in the etiology of human colon cancer

1997 • 156 citations

Calcium in milk products precipitates intestinal fatty acids and secondary bile acids and thus inhibits colonic cytotoxicity in humans.

1996 • 153 citations

Modulation of natural killer and lymphokine-activated killer cell cytotoxicity by lactoferrin

1992 • 152 citations

Diet and Cancer of the Colon and Rectum: A Case-Control Study in China

1991 • 147 citations

Oral calcium suppresses increased rectal epithelial proliferation of persons at risk of colorectal cancer.

1989 • 140 citations

Inhibitory Effect of Bifidobacterium Iongum Cultures on the Azoxymethane-Induced Aberrant Crypt Foci Formation and Fecal Bacterial -Glucuronidase

1994 • 140 citations

Calcium and Colorectal Epithelial Cell Proliferation in Sporadic Adenoma Patients: a Randomized, Double- Blinded, Placebo-Controlled Clinical Trial

1995 • 138 citations

Diet and risk of colon cancer in a large prospective study of older women: an analysis stratified on family history (Iowa, United States).

1998 • 136 citations

Adhesion of fourBifidobacteriumstrains to human intestinal mucus from subjects in different age groups

1999 • 134 citations

Relationship of food groups and water intake to colon cancer risk.

1996 • 132 citations

Colorectal cancer in rural Nebraska.

1984 • 127 citations

Growth inhibition of HT-29 human colon cancer cells by analogues of 1,25-dihydroxyvitamin D3.

1994 • 127 citations

Insulinlike growth factors and binding proteins in colon cancer

1993 • 126 citations

Colonic epithelial cell proliferation in responders and nonresponders to supplemental dietary calcium.

1989 • 125 citations

Relation of serum total cholesterol, serum triglycerides and fasting plasma glucose to colorectal carcinoma in situ

1998 • 124 citations

A prospective cohort study of intake of calcium, vitamin D, and other micronutrients in relation to incidence of rectal cancer among postmenopausal women.

1998 • 117 citations

Folates and Dairy Products: A Critical Update

2000 • 117 citations

Colon cancer in argentina. I: Risk from intake of dietary items

1992 • 116 citations

Milk consumption and cancer incidence: a Norwegian prospective study

1990 • 114 citations

The association of calcium and vitamin D, and colon and rectal cancer in Wisconsin women

1998 • 112 citations

Conjugated linoleic acid and linoleic acid are distinctive modulators of mammary carcinogenesis

1997 • 112 citations

The short-chain fatty acid butyrate induces apoptosis in colorectal tumour cell lines

1995 • 111 citations

Calcium and the prevention of colon cancer

1995 • 110 citations

Calcium Does Not Protect against Colorectal Neoplasia

1996 • 106 citations

Dietary calcium, vitamin D, and the risk of colorectal cancer in Stockholm, Sweden.

1996 • 101 citations

Foods as risk factors for colorectal cancer: a case–control study in Burgundy (France)

1999 • 101 citations

BRIEF COMMUNICATION: Growth Control of Human Colon Cancer Cells by Vitamin D and Calcium In Vitro

1992 • 101 citations

Dietary calcium and vitamin D modulate 1,2-dimethylhydrazine-induced colonic carcinogenesis in the rat.

1991 • 99 citations

Genotype Difference of Aldehyde Dehydrogenase 2 Gene in Alcohol Drinkers Influences the Incidence of Japanese Colorectal Cancer Patients

1999 • 98 citations

Calcium and Colorectal Epithelial Cell Proliferation: A Preliminary Randomized, Double-Blinded, Placebo-Controlled Clinical Trial

1993 • 96 citations

Effect of dairy products on initiation of precursor lesions of colon cancer in rats

1995 • 94 citations

Effect of calcium supplementation on mucosal cell proliferation in high risk patients for colon cancer.

1989 • 94 citations

Lactobacilli, anticarcinogenic activities and human intestinal microflora

1992 • 93 citations

K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors: effects of supplemental dietary calcium and vitamin D deficiency.

1991 • 90 citations

Dietary habits and colorectal cancer in a low‐risk area. Results from a population‐based case‐control study in southern Italy

1994 • 88 citations

Inhibition of intestinal carcinogenesis by dietary supplementation with calcium

1987 • 88 citations

Calcium supplementation decreases rectal epithelial cell proliferation in subjects with sporadic adenoma

1992 • 87 citations

Inhibition of initiation and early stage development of aberrant crypt foci and enhanced natural killer activity in male rats administered bovine lactoferrin concomitantly with azoxymethane

1997 • 83 citations

Relation of Family History of Cancer and Environmental Factors to the Risk of Colorectal Cancer: A Case-control Study

1995 • 80 citations

Diet diversity, diet composition, and risk of colon cancer (United States).

1997 • 73 citations

Food‐group consumption and colon cancer in the adelaide case‐control study. II. Meat, poultry, seafood, dairy foods and eggs

1993 • 73 citations

The antiproliferative effect of dietary calcium on colonic epithelium is mediated by luminal surfactants and dependent on the type of dietary fat.

1993 • 72 citations

Randomized, Double-Blinded, Placebo-Controlled Intervention Study With Supplemental Calcium in Families With Hereditary Nonpolyposis Colorectal Cancer

1995 • 71 citations

Long-term effects of dietary calcium on risk markers for colon cancer in patients with familial polyposis.

1990 • 67 citations

In Vivo Crypt Surface Hyperproliferation Is Decreased by Butyrate and Increased by Deoxycholate in Normal Rat Colon: Associated In Vivo Effects on c‐Fos and c‐Jun Expression

1996 • 64 citations

Calcium, dairy products, and colorectal cancer

1990 • 64 citations

Calcium Supplementation and Rectal Mucosal Proliferation: a Randomized Controlled Trial

1995 • 63 citations

Serum lipids and adenomas of the left colon and rectum.

1996 • 61 citations

Glucose intolerance and adenomas of the sigmoid colon in Japanese men (Japan).

1998 • 59 citations

Enhancement of Immune Response of Murine Peyer's Patches by a Diet Supplemented With Yogurt

1987 • 57 citations

Fermented dairy products, dietary calcium and colon cancer: A case‐control study in the netherlands

1994 • 56 citations

The effect of wheat bran fiber and calcium supplementation on rectal mucosal proliferation rates in patients with resected adenomatous colorectal polyps.

1997 • 54 citations

Patterns of milk consumption and risk of cancer

1990 • 53 citations

Antimutagenicity of cell fractions of microorganisms on potent mutagenic pyrolysates

1993 • 51 citations

Oral calcium inhibits rectal epithelial proliferation in familial adenomatous polyposis

1993 • 41 citations

Human studies of calcium supplementation and colorectal epithelial cell proliferation.

1997 • 41 citations

A placebo-controlled clinical trial.

1976 • 41 citations

Absorption of Milk-Borne Insulin-Like Growth Factor-I Into Portal Blood of Suckling Rats

2000 • 39 citations

Possible mechanisms involved in apoptosis of colon tumor cell lines induced by deoxycholic acid, short‐chain fatty acids, and their mixtures

1997 • 36 citations

Effects of Calcium and Vitamin Supplementation on Colon Cell Proliferation in Colorectal Cancer

2000 • 35 citations

Effect of oral calcium supplementation on colonie crypt cell proliferation in patients with adenomatous polyps of the large bowel

1993 • 35 citations

Application of intermediate biomarkers to studies of cancer prevention in the gastrointestinal tract: introduction and perspective

1991 • 33 citations

Chemopreventive effect of 24R,25-dihydroxyvitamin D3 in N,N'-dimethylhydrazine-induced rat colon carcinogenesis

2000 • 28 citations

Calcium supplements interact significantly with long-term diet while suppressing rectal epithelial proliferation of adenoma patients

2001 • 28 citations

The relationship between faecal bile acid profile with or without supplementation with calcium and antioxidants on recurrence and growth of colorectal polyps

1998 • 27 citations

Butyrate Alters Activity of Specific cAMP-Receptor Proteins in a Transgenic Mouse Colonic Cell Line ,

1997 • 27 citations

Calcium phosphate, bile acids and colorectal cancer

1991 • 25 citations

Effect of longterm placebo controlled calcium supplementation on sigmoidal cell proliferation in patients with sporadic adenomatous polyps.

1996 • 24 citations

The effect of calcium supplements on rectal mucosal proliferation

1995 • 22 citations

Dietary calcium does not reduce experimental colorectal carcinogenesis after small bowel resection despite reducing cellular proliferation.

1992 • 17 citations

Effect of Vitamin D on Tissue Distribution and Transport of Electrolytes,⁴⁷Ca and²⁸Mg

1966 • 14 citations

Calcium and colorectal epithelial cell proliferation in ulcerative colitis.

1997 • 14 citations

Case-control study of the relationship of diet and colon cancer.

1987 • 11 citations

Fecal and rectal mucosal diacylglycerol concentrations and epithelial proliferative kinetics.

1996 • 5 citations