Hyperthermia and Drugs

Reporting results of cancer treatment

1981 • 7,916 citations

THE TREATMENT OF MALIGNAT TUMORS BY REPEATED INOCULATIONS OF ERYSIPELAS

1893 • 946 citations

The relevance of tumour pH to the treatment of malignant disease

1984 • 886 citations

Chemotherapy of Cancer

1958 • 874 citations

An International Symposium

1960 • 827 citations

Cancer. A Comprehensive Treatise

1975 • 742 citations

Thermochemotherapy: synergism between hyperthermia (42-43 degrees) and adriamycin (of bleomycin) in mammalian cell inactivation.

1975 • 489 citations

Hyperthermia and Cancer

1982 • 474 citations

Hyperthermia and Cancer

1983 • 426 citations

Potential for therapy of drugs and hyperthermia.

1979 • 403 citations

Targeting of drugs

1977 • 396 citations

Stereochemistry of Intercalation: Interaction of Daunomycin with DNA

1972 • 360 citations

Hyperthermia in the treatment of cancer

1979 • 315 citations

Selective Heat Sensitivity of Cancer Cells

1977 • 313 citations

Metabolic aspects of the role of hyperthermia im mammalian cell inactivation and their possible relevance to cancer treatment.

1974 • 305 citations

Cloning of Human Tumor Stem Cells

1981 • 269 citations

In vitro thermochemotherapy of human colon cancer cells with cis-dichlorodiammineplatinum(II) and mitomycin C.

1980 • 266 citations

Binding of cis - and trans -Dichlorodiammineplatinum(II) to DNA: Evidence for Unwinding and Shortening of the Double Helix

1979 • 254 citations

Interaction of bleomycin with DNA.

1978 • 250 citations

Results of hyperthermic perfusion for melanoma of the extremities.

1975 • 223 citations

Interactions of hyperthermia and chemotherapy in animals.

1979 • 204 citations

Applied Respiratory Physiology

1987 • 204 citations

Ethanol-induced tolerance to heat and to adriamycin

1978 • 201 citations

The Influence of Membrane Lipid Composition and Procaine on Hyperthermic Death of Cells

1977 • 184 citations

Thermal enhancement of DNA damage in mammalian cells treated with cis-diamminedichloroplatinum(II).

1980 • 172 citations

Hyperthermic perfusion with chemotherapy for cancers of the extremities.

1969 • 172 citations

Cytotoxic Effects of Hyperthermia and Adriamycin on Chinese Hamster Cells2

1976 • 163 citations

Cancer a Comprehensive Treatise 2

1975 • 160 citations

Enhancement by hyperthermia of the in vitro cytotoxicity of mitomycin C toward hypoxic tumor cells.

1981 • 157 citations

Treatment of solid L1210 murine tumors with local hyperthermia and temperature-sensitive liposomes containing methotrexate.

1980 • 155 citations

Treatment of implanted peritoneal cancer in rats by continuous hyperthermic peritoneal perfusion in combination with an anticancer drug.

1984 • 129 citations

Whole Body Hyperthermia: A Phase-l Trial of a Potential Adjuvant to Chemotherapy

1979 • 129 citations

Treatment of far-advanced bronchogenic carcinoma by extracorporeally induced systemic hyperthermia

1979 • 127 citations

In vitro-in vivo studies on the susceptibility of the solid Yoshida sarcoma to drugs and hyperthermia (42 degrees).

1974 • 124 citations

Therapeutic Synergism of Hyperthermia-cis-Platinum in a Mouse Tumor Model<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1980 • 122 citations

Cloning of human tumor stem cells

1980 • 119 citations

A Prospective Randomized Study of Regional Extremity Perfusion in Patients with Malignant Melanoma

1984 • 115 citations

DNA-binding characteristics of acridinylmethanesulphonanilide drugs: Comparison with antitumour properties

1976 • 114 citations

Effects of adriamycin on surface properties of sarcoma 180 ascites cells

1976 • 113 citations

Enhanced cell killing by bleomycin and 43 degrees hyperthermia and the inhibition of recovery from potentially lethal damage.

1975 • 111 citations

Temperature dependence of adriamycin, cis-diamminedichloroplatinum, bleomycin, and 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity in vitro.

1983 • 110 citations

Selective delivery of liposome-associated cis-dichlorodiammineplatinum(II) by heat and its influence on tumor drug uptake and growth.

1981 • 109 citations

Influence of drugs and synchrony on the hyperthermic killing of HeLa cells.

1973 • 109 citations

Effect of pH and elevated temperatures on the cytotoxicity of some chemotherapeutic agents on Chinese hamster cells in vitro.

1983 • 108 citations

Total-body hyperthermia with and without chemotherapy for advanced human neoplasms.

1979 • 100 citations

A BLEOMYCIN-INACTIVATING ENZYME IN MOUSE LIVER

1974 • 99 citations

Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine

1977 • 98 citations

Quercetin, an inhibitor of lactate transport and a hyperthermic sensitizer of HeLa cells.

1984 • 96 citations

Survival and regional disease control after isolation-perfusion for invasive stage I melanoma of the extremities

1976 • 94 citations

Combined adriamycin and hyperthermia treatment of a murine mammary carcinoma in vivo.

1976 • 94 citations

Thermal Enhancement of Thio-TEPA Cytotoxicity2

1973 • 89 citations

Effect of Heating on Lethality Due to Hyperthermia and Selected Chemotherapeutic Drugs<xref ref-type="fn" rid="fn2">2</xref>

1982 • 81 citations

The effect of hyperthermia and melphalan on survival of human fibroblast strains and melanoma cell lines.

1977 • 77 citations

Temperature-dependent permeability of large unilamellar liposomes

1984 • 76 citations

Pharmacokinetics and Temperature

1974 • 75 citations

Thermochemotherapy for melanoma metastases in liver

1982 • 72 citations

Interaction of amphotericin B and 43 degrees hyperthermia.

1977 • 67 citations

Experimental and Clinical Aspects of Hyperthermia Applied to the Treatment of Cancer with Special Reference to the Role of Ultrasonic and Microwave Heating

1976 • 67 citations

Relationship between Hyperthermic Cell Killing and Protein Denaturation by Alcohols

1981 • 66 citations

Delivery of Antitumor Drug to Bladder Cancer by Use of Phase Transition Liposomes and Hyperthermia

1982 • 65 citations

Magnetic-induction hyperthermia. Results of a 5-year multi-institutional national cooperative trial in advanced cancer patients

1985 • 64 citations

Hyperthermia and Local Anesthetics: Potentiation of Survival of Tumor-Bearing Mice

1979 • 63 citations

Ultrasonic enhancement of nitrogen mustard cytotoxicity in mouse leukemia

1976 • 62 citations

Hyperthermia (42°C) as an Adjuvant to Radiotherapy and Chemotherapy in the Treatment of the Allogeneic VX2 Carcinoma in the Rabbit

1973 • 56 citations

Renal failure and platinum pharmacokinetics in three patients treated with cis-diamminedichloroplatinum(II) and whole-body hyperthermia

1983 • 55 citations

Sudden Myelopathy Secondary to Therapeutic Total-Body Hyperthermia after Spinal-Cord Irradiation

1981 • 55 citations

Effects of lonidamine alone or combined with hyperthermia in some experimental cell and tumour systems

1983 • 53 citations

Selective Heating and Cooling of Tissue in Cancer Chemotherapy

1962 • 52 citations

Effects of systemically administered bleomycin or adriamycin with local hyperthermia on primary tumor and lung metastases.

1979 • 51 citations

Studies on recovery from chemically induced damage in mammalian cells.

1975 • 50 citations

Lonidamine: A Hyperthermic Sensitizer of HeLa Cells in Culture and of the Meth-A Tumor in vivo

1984 • 49 citations

Local recurrence and survival in patients with (clark level IV/V and over 1.5-mm thickness) stage I malignant melanoma of the extremities after regional perfusion

1981 • 48 citations

Human tumour pH changes following hyperthermia and radiation therapy

1984 • 48 citations

Response of two mouse tumours to hyperthermia with CCNU or melphalan

1982 • 46 citations

Role of whole-body hyperthermia in the treatment of neoplastic disease: its current status and future prospects.

1984 • 45 citations

Hyperthermic adjuvant perfusion chemotherapy for stage I malignant melanoma of the extremity with literature review

1983 • 45 citations

Enhancement of cysteamine cytotoxicity by hyperthermia and its modification by catalase and superoxide dismutase in Chinese hamster ovary cells.

1984 • 45 citations

Whole-body hyperthermia in cancer therapy: a report of a phase I–II study

1983 • 44 citations

Effect of hyperglycemia on thermochemotherapy of a spontaneous murine fibrosarcoma.

1983 • 43 citations

A clinical investigation of total-body hyperthermia as cancer therapy.

1979 • 43 citations

Whole-body hyperthermia and chemotherapy for treatment of patients with advanced, refractory malignancies.

1982 • 42 citations

Synergistic cell killing by antitumor agents and hyperthermia in cultured cells.

1980 • 41 citations

Protective effect of hyperthermia against the cytotoxicity of actinomycin D on Chinese hamster cells.

1978 • 40 citations

Selective enhancement of the cytotoxicity of the bleomycin derivative, peplomycin, by local anesthetics alone and combined with hyperthermia.

1982 • 40 citations

Combined hyperthermia andcis-diamminedichloroplatinum in BD IX rats with transplanted BT₄A tumours

1985 • 39 citations

Whole‐Body Hyperthermia

1987 • 39 citations

15 Years� Experience with Hyperthermic Perfusion for Treatment of Soft Tissue Sarcoma and Malignant Melanoma of the Extremities

2015 • 38 citations

Treatment of bladder cancer with a combination of hyperthermia, radiation and bleomycin

1984 • 37 citations

Human melanoma colony formation in soft agar.

1980 • 37 citations

Effect of timing and sequence of hyperthermia and cyclophosphamide on a neurogenic rat tumor (BT4A) in vivo

1983 • 36 citations

Doxorubicin cytotoxicity enhanced by local anesthetics in a human melanoma cell line.

1982 • 35 citations

Reversal of resistance to methotrexate by hyperthermia in Chinese hamster ovary cells.

1981 • 35 citations

The Treatment of Stage I Melanoma of the Extremities with Regional Hyperthermic Isolation Perfusion

1982 • 35 citations

Preclinical trial of a radiant heat device for whole-body hyperthermia using a porcine model.

1983 • 34 citations

The Synergistic Effect of Hyperthermia and Chemotherapy on Murine Transitional Cell Carcinoma

1984 • 34 citations

Treatment of congenital clubfoot from an anatomical point of view.

1948 • 33 citations

Effect of whole-body hyperthermia on the disposition and metabolism of adriamycin in rabbits.

1978 • 32 citations

Systemic lidocaine enhancement of hyperthermia-induced tumor regression in transplantable murine tumor models.

1983 • 31 citations

Vascular Perfusion in Cancer Therapy

1983 • 31 citations

Thermal enhancement of DNA damage by an alkylating agent in human cells

1973 • 31 citations

Sensitivity of normal mouse marrow and RIF-1 tumour to hyperthermia combined with cyclophosphamide or BCNU: a lack of therapeutic gain

1982 • 31 citations

Hyperthermic potentiation of doxorubicin and 4′-epi-doxorubicin in a transplantable neurogenic rat tumor (BT4A) in BD IX rats

1983 • 30 citations

Thermal biology and physiology in clinical hyperthermia: current status and future needs.

1984 • 30 citations

Enhancement of bleomycin activity against Lewis lung tumors in mice by local hyperthermia.

1979 • 28 citations

Evaluation of whole-body hyperthermia as an adjunct to chemotherapy in murine tumors.

1979 • 28 citations

Enhanced effect of combined hyperthermia and chemotherapy (bleomycin, BCNU) in a neurogenic rat tumour (BT4A) in vivo.

1982 • 28 citations

Effect of temperature on the cytotoxicity of vindesine, amsacrine, and mitoxantrone.

1983 • 27 citations

Synergism between hyperthermia and cyclophosphamide in vivo: The effect of dose fractionation

1981 • 26 citations

Potentiation of differential hyperthermic sensitivity of AKR leukemia and normal bone marrow cells by lidocaine or thiopental

1984 • 25 citations

The effect of systemic hyperthermia on melphalan pharmacokinetics in mice

1985 • 25 citations

Predictability of response to clinical thermochemotherapy by the clonogenic assay

1983 • 25 citations

Enhancement by hyperthermia of the effect of BCNU against the EMT6 mouse tumor.

1978 • 25 citations

Enhancement by Corynebacterium parvum of the normal and tumor tissue response to hyperthermia.

1978 • 24 citations

Effect of Hyperthermia Alone and in Combination with Anticancer Drugs on the Viability of P388 Leukemic Cells

1984 • 24 citations

Application of heat to cancer chemotherapy--experimental studies.

1967 • 24 citations

Sur l’Existence des Mesures des Condensateurs

1967 • 23 citations

The interaction of thermal tolerance with drug cytotoxicity in vitro

1979 • 23 citations

In vitro activation of dacarbazine (DTIC) for a human tumor cloning system

1983 • 23 citations

Antitumor Effect of Combined Interferon and Hyperthermia in Mice

1982 • 21 citations

Combined Cytotoxicity Effect of Hyperthermia and Anthracycline Antibiotics on Human Tumor Cells<xref ref-type="fn" rid="FN2">2</xref>

1985 • 21 citations

Effect of extracorporeally induced total body hyperthermia for cancer on cardiovascular function.

1984 • 20 citations

Effect of Temperature upon the In Vitro Action of Anticancer Agents on VX2 Carcinoma

1961 • 19 citations

The effect of tissue temperature on the binding of alkylating agents in the isolation perfusion treatment of cancer.

1961 • 19 citations

Distribution of adriamycin in mice under conditions of local hyperthermia which improve systemic drug therapy.

1980 • 19 citations

Influence of heat on the intracellular uptake and radiosensitization of 2-nitroimidazole hypoxic cell sensitizers in vitro.

1983 • 19 citations

Synergistic effect of combined hyperthermia and a nitrosourea in treatment of a murine ependymoblastoma.

1980 • 19 citations

Altered hepatic disposition of doxorubicin in the perfused rat liver at hyperthermic temperatures.

1982 • 19 citations

Effects of Cytostatic Drugs and 40.5°C Hyperthermia on Human Bone Marrow Progenitors (CFU-C) and Human Clonogenic Tumor Cells Implanted Into Mice<xref ref-type="fn" rid="FN2">2</xref>

1985 • 18 citations

Enhancement of the thermal response of animal tumors by Corynebacterium parvum.

1979 • 17 citations

Reduction of tumor burden in a murine osteosarcoma following hyperthermia combined with cyclophosphamide.

1984 • 17 citations

Hyperthermia and bleomycin schedules on V79 Chinese hamster cell cytotoxicity in vitro.

1983 • 16 citations

Hyperthermochemotherapeuticin vivo isolated perfusion of the rat liver

1983 • 16 citations

Structure-Activity Relationships of Anthraquinones in Some Pathological Conditions

1980 • 16 citations

Effects of cytostatic drugs and 40.5°C hyperthermia on human clonogenic tumor cells

1985 • 16 citations

Hyperthermia Potentiates Doxorubicin-Related Cardiotoxic Effects

1979 • 16 citations

Comparative Study of the Effects of Hyperthermia and BCNU on BCNU-Sensitive and BCNU-Resistant 9L Rat Brain Tumor Cells

1985 • 16 citations

Interaction of ultrasonic hyperthermia with two alkylating agents in a murine bladder tumor.

1983 • 16 citations

Combined treatment of a solid tumour by local hyperthermia and actionomycin D

1978 • 16 citations

Potentiation of bleomycin cytotoxicity toward cultured mouse cells by hyperthermia and ethanol.

1981 • 15 citations

Hyperthermic modification of cyclophosphamide metabolism in rat hepatic microsomes and liver slices

1981 • 15 citations

Potentiation of melphalan by systemic hyperthermia in mice: Therapeutic gain for mouse lung microtumours

1985 • 15 citations

Response of EMT6 multicellular tumour spheroids to hyperthermia and cytotoxic drugs

1981 • 15 citations

Temperature dependence of leukemic cell destruction by alkyl-lysophospholipids (NSC 324368).

1983 • 14 citations

Observations on the Cellular Effects of Ethanol and Hyperthermia in Vivo

1983 • 14 citations

Effects of systemic hyperthermia and intrahepatic infusion with 5-fluorouracil

1982 • 13 citations

An experimental study of enhanced cell killing by hyperthermia and bleomycin

1983 • 13 citations

Palliation of advanced head and neck cancer with radiofrequency hyperthermia and cytotoxic chemotherapy.

1984 • 12 citations

Effect of hyperthermia on DNA single-strand breaks induced by bleomycin in Hela cells.

1979 • 12 citations

Extrakorporal induzierte Ganzkörperhyperthermie bei konventionell inkurablen Malignompatienten

2008 • 12 citations

Systemic thermochemotherapy in a rat model.

1983 • 12 citations

Synergistic effect of hyperthermia, papaverine, and chemotherapy in murine neuroblastoma

1980 • 12 citations

Experimental hyperthermic isolation-perfusion using cis-diamminedichloroplatinum(II).

1983 • 12 citations

Thermochemotherapy for Malignant Melanoma: Combination Therapy of ACNU and Hyperthermia in Mice

1984 • 12 citations

Ultrasonic hyperthermia and drugs as therapy for human tumor xenografts.

1982 • 12 citations

Sensitization of Combined cis-Platinum and Cyclophosphamide by Local Hyperthermia in Mice bearing the Lewis Lung Carcinoma

1984 • 11 citations

Cancer therapy by hyperthermia and radiation : proceedings of the 2nd international symposium, Essen, June 2-4, 1977

1978 • 11 citations

The combined effect of bleomycin and hyperthermia on the adenocarcinoma 284 of the C3H mouse

1981 • 11 citations

The effect of whole body hyperthermia on 5-fluorouracil pharmacokinetics in vivo and clonogenicity of mammalian colon cancer cells.

1984 • 10 citations

Interactions between misonidazole and hyperthermia in EMT6 spheroids

1981 • 10 citations

Locoregional High-Frequency Hyperthermia and Temperature Measurement

1986 • 10 citations

Effect of Whole Body Hyperthermia and BCNU on the Development of Radiation Myelitis in the Rat

1984 • 10 citations

DNA damage produced by combined hyperglycemia and hyperthermia in two mouse fibrosarcoma tumors in vivo

1984 • 9 citations

Transmembrane ion gradients and thermochemotherapy.

1982 • 9 citations

Increased in vitro toxicity to mouse bone marrow with 1,3-bis(2-chloroethyl)-1-nitrosourea and hyperthermia.

1979 • 9 citations

Hyperthermia and chemotherapy: When will they be used in the clinical treatment of cancer?

1983 • 8 citations

Responses of RIF tumors to heat and drugs: dependence on tumor size.

1984 • 8 citations

Hyperthermic potentiation of chromosome aberrations by anticancer antibiotics

1982 • 8 citations

Der in vitro-Effekt der Hyperthermie auf den Einbau von Nucleinsäurevorläufern in Tumoren und normale Gewebe

1973 • 8 citations

Blood flow-interrupting hyperthermic chemotherapy on established autochthonous mouse sarcoma induced by 3-methylcholanthrene.

1978 • 8 citations

Whole-Body Hyperthermia. A Systemic Treatment for Disseminated Cancer

1977 • 8 citations

Antitumor effect of thermodifferential chemotherapy with carboquone on Ehrlich carcinoma.

1979 • 7 citations

Control of Lewis lung carcinoma by combined treatment with local hyperthermia and cyclophosphamide: preliminary results.

1979 • 7 citations

Synergistic enhancement of bleomycin cytotoxicity toward tumor cells in culture by a combination of ethanol and moderate hyperthermia.

1981 • 7 citations

Thermal enhancement of bleomycin-induced tumour growth delay: the effect of dose fractionation

1983 • 7 citations

Hyperthermic modification of drug effectiveness for reproductive death of cultured mammalian cells.

1984 • 7 citations

Die isolierte Leberperfusion

1985 • 7 citations

Altered hepatic functions and microsomal activity in perfused rat liver by hyperthermia combined with alkylating agents.

1983 • 7 citations

Inhibition of DMSO-induced differentiation by hyperthermia in a murine erythroleukemia cell system

1984 • 7 citations

Chemotherapy by Isolated Regional Perfusion for Melanoma of the Limbs

1983 • 7 citations

Delivery of Drugs in Temperature-Sensitive Liposomes

1982 • 7 citations

New technologies to combat malignant tumours of the brain.

1982 • 6 citations

Klinisch-chemische und immunologische Ver�nderungen bei Gesunden nach einer einst�ndigen 40� C-Ganzk�rperhyperthermie

1978 • 6 citations

Preliminary results in the treatment of oat cell carcinoma of the lung by combined application of chemotherapy (CT) and whole-body hyperthermia.

1982 • 6 citations

Work in progress: the effect of heat on bleomycin cytotoxicity in vitro and on the accumulation of 57Co-bleomycin in heat-treated rat tumors.

1983 • 5 citations

[In vitro effect of hyperthermia on the incorporation rate of nucleic acid precursors in tumours and normal tissues].

1973 • 5 citations

In Vivo Cytotoxicity of Misonidazole and Hyperthermia in a Transplanted Mouse Mammary Tumor

1983 • 5 citations

Effects of hyperthermia and ethanol on the cytotoxicity of bleomycin, adriamycin, cis-diamminedichloroplatinum(II) and macromomycin toward hela cells.

1982 • 5 citations

Systemic thermotherapy (whole body hyperthermia).

1979 • 5 citations

[Studies on 479 cases of infrared hyperthermia treatments. Contribution to the method of whole body hyperthermia].

1979 • 5 citations

Klinisch-chemische Untersuchungen an Tumorpatienten unter Zytostatica- und Ganzk�rperhyperthermiebehandlung

1979 • 4 citations

Temperature effect on mitoxantrone cytotoxicity in Chinese hamster cells in vitro.

1985 • 4 citations

The treatment of head and neck carcinoma with Adriamycin and Belomycin using adjuvant hyperthermia

1982 • 4 citations

Wirkung der lokalen moderaten Hyperthermie in Kombination mit einer Chemotherapie durch Cyclophosphamid oder N-Nitroso-1,3-bis-(2-chlorethyl harnstoff (BCNU) auf das in das Colon descendens der Ratte transplantierte Yoshida-Sarkom

1983 • 4 citations

Wirkung der lokalen moderaten Hyperthermie in Kombination mit einer Chemotherapie durch N-Nitroso-1,3-bis-(2-chloroethyl)-harnstoff (BCNU) auf das in das Colon descendens der Ratte transplantierte Yoshida-Sarkom

1984 • 3 citations

The effect of hyperthermia alone or in combination with actinomycin D on the RNA metabolism of solid tumors in children.

1981 • 3 citations

Survival of Pleomorphic Sarcoma-37 Transplanted Virgin Female DBA/2J Mice: Hyperthermia and Hyperglycemia, Alone and in Combination with Drugs

1977 • 3 citations

Enhancement of thermal response of normal and malignant tissues by Corynebacterium parvum.

1984 • 3 citations

Moderate-temperature whole-body hyperthermia in the treatment of malignant disease.

1982 • 3 citations

The effect of hyperthermia on survival in transplanted lymphosarcoma

1978 • 3 citations

Effects of Alcohol and Hyperthermia on Normal and Leukemic Lymphocytes

1981 • 3 citations

[Increased cytotoxicity of misonidazole by pH reduction and 41 degrees C hyperthermia in Chinese hamster cells].

1982 • 3 citations

[Experimental studies on combined chemotherapy with hyperthermia and ethanol for advanced esophageal cancer. II. Effects of combined treatments on tumor growth in tumor-bearing mice].

1984 • 3 citations

Book Review: Rational Basis for Chemotherapy

1983 • 2 citations

Stimulation of resistance against local tumor growth, of hosts pretreated by combined local hyperthermia and X-irradiation.

1978 • 2 citations

The University of Mississippi Medical Center

2005 • 1 citations

Clinical Requirements of Local and Regional Hyperthermia Application

1986 • 1 citations

Morphological Damage Induced in vivo by Lonidamine on Human Metastatic Cancer Cells

1984 • 1 citations

Deleted Work

1955 • 0 citations