Influence of heat on the intracellular uptake and radiosensitization of 2-nitroimidazole hypoxic cell sensitizers in vitro.

A New Substituent Constant, π, Derived from Partition Coefficients

1964 • 1,353 citations

Cancer. A Comprehensive Treatise

1975 • 742 citations

Thermochemotherapy: synergism between hyperthermia (42-43 degrees) and adriamycin (of bleomycin) in mammalian cell inactivation.

1975 • 489 citations

THE INTERSTITIAL FLUID OF SOLID TUMORS.

1964 • 240 citations

Partition Coefficient as a Guide to the Development of Radiosensitizers Which Are Less Toxic Than Misonidazole

1980 • 214 citations

Hypoxic Sensitizers: Radiobiological Studies at the Cellular Level

1975 • 205 citations

Interactions of hyperthermia and chemotherapy in animals.

1979 • 204 citations

Hypoxia-dependent reduction of 1-(2-nitro-1-imidazolyl)-3-methoxy-2-propanol by Chinese hamster ovary cells and KHT tumor cells in vitro and in vivo.

1976 • 195 citations

SR-2508: A 2-nitroimidazole amide which should be superior to misonidazole as a radiosensitizer for clinical use

1981 • 180 citations

Radiosensitizing and Toxic Effects of the 2-Nitroimidazole Ro-07-0582 in Hypoxic Mammalian Cells

1976 • 169 citations

Effect of hyperthermia on differential cytotoxicity of a hypoxic cell radiosensitizer, Ro-07-0582, on mammalian cells in vitro

1977 • 140 citations

Enhanced cell killing by bleomycin and 43 degrees hyperthermia and the inhibition of recovery from potentially lethal damage.

1975 • 111 citations

Extracellular Compartments of Solid Tumors

1975 • 105 citations

Cytotoxicity as an indicator for transport mechanism. Evidence that melphalan is transported by two leucine-preferring carrier systems in the L1210 murine leukemia cell

1979 • 100 citations

Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine

1977 • 98 citations

Estimation of the hypoxic cell-sensitiser misonidazole and its O-demethylated metabolite in biological materials by reversed-phase high-performance liquid chromatography

1978 • 93 citations

Interaction of hyperthermia and the hypoxic cell sensitizer Ro-07-0582 on the EMT6 mouse tumour

1977 • 57 citations

Cytotoxicity of misonidazole and DNA damage in hypoxic mammalian cells.

1978 • 39 citations

Effect of hyperthermia on cytotoxicity of the radiosensitizer Ro-07-0582 in a solid mouse tumour

1977 • 39 citations

Factors Influencing Intracellular Uptake and Radiosensitization by 2-Nitroimidazoles in Vitro

1983 • 31 citations

The optimum time for irradiation relative to tumour concentration of hypoxic cell sensitizers

1980 • 24 citations

Structure-activity relationships of 1-substituted 2-nitroimidazoles: effect of partition coefficient and side-chain hydroxyl groups on radiosensitization in vitro.

1982 • 23 citations

In vitro hypoxic cytotoxicity of nitroimidazoles: Uptake and cell cycle phase specificity

1982 • 22 citations

Enhancement of radioresponse of a mouse mammary carcinoma to combined treatments with hyperthermia and radiosensitizer misonidazole.

1979 • 12 citations

The hyperthermic potentiation of the cytotoxic effect of misonidazole on the EMT6 mouse tumour: relevance of in vitro measurement of in vivo effect.

1978 • 11 citations

Cytotoxicity of radiosensitizers in multicell spheroids: combination treatment with hyperthermia.

1978 • 10 citations