The noncompetitive N-methyl-D-aspartate antagonists, MK-801, phencyclidine and ketamine, increase the potency of general anesthetics

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Ethanol Inhibits NMDA-Activated Ion Current in Hippocampal Neurons

1989 • 1,456 citations

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate

1983 • 1,400 citations

Minimum Alveolar Anesthetic Concentration

1965 • 847 citations

N‐Methyl‐D‐Aspartate Receptors and Ethanol: Inhibition of Calcium Flux and Cyclic GMP Production

1989 • 566 citations

The novel anticonvulsant MK‐801 binds to the activated state of the N‐methyl‐<scp>d</scp>‐aspartate receptor in rat brain

1987 • 452 citations

SELECTIVE ACTION OF ANESTHETICS ON SYNAPSES AND AXONS IN MAMMALIAN SYMPATHETIC GANGLIA

1952 • 329 citations

MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys.

1988 • 302 citations

Pentobarbitone pharmacology of mammalian central neurones grown in tissue culture.

1978 • 284 citations

Sigma and phencyclidine-like compounds as molecular probes in biology

1988 • 251 citations

Multiple sites for the regulation of the N-methyl-D-aspartate receptor.

1988 • 208 citations

Ethanol potentiates and blocks NMDA‐activated single‐channel currents in rat hippocampal pyramidal cells

1989 • 204 citations

The novel anticonvulsant MK-801: a potent and specific ligand of the brain phencyclidine/gd-receptor

1987 • 197 citations

The effects of pentobarbital and related compounds on frog motoneurons

1980 • 187 citations

The cataleptic state induced by ketamine: a review of the neuropharmacology of anesthesia

1972 • 163 citations

The anti-excitotoxic effects of certain anesthetics, analgesics and sedative-hypnotics

1986 • 147 citations

ANAESTHETICS DEPRESS THE SENSITIVITY OF CORTICAL NEURONES TO <scp>l</scp>‐GLUTAMATE

1976 • 139 citations

Sites of antagonist action on N-methyl-D-aspartic acid receptors studied using fluctuation analysis and a rapid perfusion technique

1988 • 125 citations

A study of the interaction of the hypnotic effects and of the toxic effects of chloral hydrate and ethanol.

1970 • 93 citations

Neurochemical actions of anesthetic drugs on the gamma-aminobutyric acid receptor-chloride channel complex.

1987 • 83 citations

The action of ether and methoxyflurane on synaptic transmission in isolated preparations of the mammalian cortex.

1975 • 71 citations

The noncompetitive N-methyl-d-aspartate receptor antagonist, MK-801 profoundly reduces volatile anesthetic requirements in rabbits

1989 • 61 citations

The behavioral effects of phencyclidine in animals.

1978 • 49 citations

Acute ethanol alters the firing pattern and glutamate response of cerebellar Purkinje neurons in culture

1987 • 34 citations

Phencyclidine analogues inhibit NMDA-stimulated [3H]GABA release from cultured cortex neurons

1987 • 29 citations

Development of spontaneous and glutamate-evoked activity is altered by chronic ethanol in cultured cerebellar Purkinje neurons

1987 • 28 citations

Phencyclidine in combination with pentobarbital: Supra-additive effects on complex operant behavior in pigeons

1982 • 21 citations

Interactions between phencyclidine and central nervous system depressants evaluated in mice and rats

1987 • 21 citations

Effect of ether inhalation upon spinal cord and root action potentials

1952 • 20 citations

Anaesthetic and convulsant ethers act on different sites at the crab neuromuscular junction in vitro

1977 • 15 citations

Clinical implications of behavioral pharmacology research on phencyclidine.

1986 • 14 citations

Phencyclidine in combination with pentobarbital: Supra-additive effects on complex operant behavior in patas monkeys

1982 • 13 citations

Toxicity of phencyclidine and ethanol in combination.

1985 • 12 citations

The effects of phencyclidine on ethanol and sodium hexobarbital in mice

1977 • 12 citations

Anticonvulsant properties of phencyclidine and ketamine.

1986 • 4 citations