Substance P and somatostatin inhibit calcium channels in rat sympathetic neurons via different G protein pathwavs

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

A Potent Nonpeptide Antagonist of the Substance P (NK ₁ ) Receptor

1991 • 875 citations

Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence

1989 • 815 citations

Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.

1992 • 766 citations

Charge Movement Associated with the Opening and Closing of the Activation Gates of the Na Channels

1974 • 746 citations

Rates of diffusional exchange between small cells and a measuring patch pipette

1988 • 712 citations

Elementary properties and pharmacological sensitivities of calcium channels in mammalian peripheral neurons

1989 • 667 citations

GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels

1986 • 666 citations

Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents

1991 • 576 citations

Mammalian Tachykinin Receptors

1991 • 502 citations

G protein-coupled mechanisms and nervous signaling

1992 • 474 citations

Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells

1984 • 436 citations

G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides

1990 • 428 citations

Ca2+ channels in rat central and peripheral neurons: High-threshold current resistant to dihydropyridine blockers and ω-conotoxin

1991 • 423 citations

Peptidergic transmission in sympathetic ganglia of the frog.

1982 • 387 citations

LHRH and GTP-γ-S modify calcium current activation in bullfrog sympathetic neurons

1990 • 350 citations

The effects of substance P on histamine and 5‐hydroxytryptamine release in the rat

1982 • 347 citations

Activation of a muscarinic receptor selectively inhibits a rapidly inactivated Ca2+ current in rat sympathetic neurons.

1987 • 285 citations

Techniques used in the identification and analysis of function of pertussis toxin-sensitive guanine nucleotide binding proteins

1988 • 275 citations

Double‐pulse calcium channel current facilitation in adult rat sympathetic neurones.

1991 • 248 citations

Substance P raises neuronal membrane excitability by reducing inward rectification

1985 • 230 citations

A diffusible second messenger mediates one of the pathways coupling receptors to calcium channels in rat sympathetic neurons

1991 • 221 citations

Activity and Distribution of Binding Sites in Brain of a Nonpeptide Substance P (NK ₁ ) Receptor Antagonist

1991 • 221 citations

Substance P reduces acetylcholine‐induced currents in isolated bovine chromaffin cells.

1984 • 206 citations

Mechanism of muscarinic receptor-induced K+ channel activation as revealed by hydrolysis-resistant GTP analogues.

1988 • 205 citations

Synaptic events in sympathetic ganglia

1978 • 202 citations

Expression cloning of a rat brain somatostatin receptor cDNA.

1992 • 201 citations

Pertussis toxin and voltage dependence distinguish multiple pathways modulating calcium channels of rat sympathetic neurons

1992 • 192 citations

Reconstitution of Somatostatin and Muscarinic Receptor Mediated Stimulation of K⁺Channels by Isolated G_KProtein in Clonal Rat Anterior Pituitary Cell Membranes *

1987 • 188 citations

M-currents in voltage-clamped mammalian sympathetic neurones

1981 • 186 citations

Somatostatin blocks a calcium current in rat sympathetic ganglion neurones.

1989 • 178 citations

Modulation of vertebrate neuronal calcium channels by transmitters

1991 • 175 citations

Intracellular Ca2+ buffers disrupt muscarinic suppression of Ca2+ current and M current in rat sympathetic neurons.

1991 • 174 citations

Characterization of muscarinic receptor subtypes inhibiting Ca2+ current and M current in rat sympathetic neurons.

1992 • 172 citations

Similar effects of substance P and related peptides on salivation and on phosphatidylinositol turnover in rat salivary glands.

1980 • 168 citations

Second messenger‐activated calcium influx in rat peritoneal mast cells.

1989 • 163 citations

Characterization of the substance P receptor in rat brain cortex membranes and the inhibition of radioligand binding by guanine nucleotides.

1983 • 151 citations

Identification of the subunits of GTP-binding proteins coupled to somatostatin receptors.

1991 • 144 citations

Inhibition of Ca2+ and K+ channels in sympathetic neurons by neuropeptides and other ganglionic transmitters

1990 • 137 citations

Agonists that suppress M-current elicit phosphoinositide turnover and Ca2+ transients, but these events do not explain M-current suppression

1988 • 132 citations

The Somatostatin Receptor Is Directly Coupled to Adenylate Cyclase in GH4Ci Pituitary Cell Membranes*

1984 • 130 citations

Pertussis toxin-insensitive G protein mediates substance P-induced inhibition of potassium channels in brain neurons.

1988 • 126 citations

Somatostatin inhibits multireceptor stimulation of cyclic AMP formation and corticotropin secretion in mouse pituitary tumor cells.

1982 • 125 citations

Inhibition of N- and L-type calcium channels by muscarinic receptor activation in rat sympathetic neurons

1992 • 115 citations

Muscarinic and peptidergic excitation of bull‐frog sympathetic neurones.

1985 • 113 citations

Voltage‐ and time‐dependent inhibition of neuronal calcium channels by a GTP‐binding protein in a mammalian cell line.

1992 • 104 citations

Differential regulation of peptide and catecholamine characters in cultured sympathetic neurons

1985 • 104 citations

Analogs of somatostatin selectively label distinct subtypes of somatostatin receptors in rat brain.

1989 • 102 citations

A guanine nucleotide-dependent regulatory protein couples substance P receptors to phospholipase C in rat parotid gland

1986 • 95 citations

Protein kinase C is not necessary for peptide-induced suppression of M current or for desensitization of the peptide receptors.

1989 • 93 citations

Neurotransmitter modulation of calcium channels in rat sympathetic neurons

1991 • 91 citations

Role of the N-terminal arginine in the histamine-releasing activity of substance P, bradykinin and related peptides

1989 • 83 citations

Substance P and Somatostatin Regulate Sympathetic Noradrenergic Function

1983 • 78 citations

Characterization of ligand-binding properties and selectivities of three rat tachykinin receptors by transfection and functional expression of their cloned cDNAs in mammalian cells.

1991 • 75 citations

Substance P in the superior cervical ganglion and the submaxillary gland of the rat

1980 • 69 citations

Substance P modulates single-channel properties of neuronal nicotinic acetylcholine receptors

1990 • 62 citations

Brain somatostatin receptor-G protein interaction. G alpha C-terminal antibodies demonstrate coupling of the soluble receptor with Gi(1-3) but not with Go.

1992 • 49 citations

Selective agonists of tachykinin binding sites

1990 • 47 citations

Modulation of ion channels by somatostatin and acetylcholine

1992 • 39 citations

Simultaneous expression of the SP-peptidergic and noradrenergic phenotypes in rat sympathetic neurons

1984 • 39 citations

Modulation of M current in frog sympathetic ganglion cells.

1990 • 37 citations

Regulation of Substance P Receptor Affinity by Guanine Nucleotide‐Binding Proteins

1989 • 35 citations

Different GTP-binding proteins mediate regulation of calcium channels by acetylcholine and noradrenaline in rat sympathetic neurons

1989 • 30 citations

Selectivity of the effects of guanosine-5'-O-(2-thiodiphosphate) on agonist inhibition of the M-current in amphibian sympathetic neurons

1991 • 28 citations

Substance P stimulation of polyphosphoinositide hydrolysis in rat anterior pituitary membranes involves a GTP-dependent mechanism

1991 • 21 citations

Differences in neurokinin receptor pharmacology between rat and guinea‐pig superior cervical ganglia

1992 • 15 citations