The Effect of Aging on Susceptibility to Infection

Cancer Incidence in Five Continents

1970 • 8,763 citations

Infectious Diseases of the Fetus and Newborn Infant

1984 • 2,479 citations

THE INFLUENCE OF IMMUNOLOGICALLY COMMITTED LYMPHOID CELLS ON MACROPHAGE ACTIVITY IN VIVO

1969 • 932 citations

AGEING, IMMUNE RESPONSE, AND MORTALITY

1974 • 480 citations

Cancer and ageing in mice and men

1975 • 466 citations

Pathogenesis of Infectious Disease

1978 • 371 citations

The Immunologic Theory of Aging

1971 • 363 citations

Impaired Lymphocyte Function in Aged Humans

1974 • 350 citations

Immunological studies of aging. II. Loss of IgG and high avidity plaque-forming cells and increased suppressor cell activity in aging mice.

1976 • 239 citations

The Cell Biology of Human Aging

1976 • 235 citations

Autoimmunity in a rural community.

1972 • 207 citations

Age-Related Changes in the Subsets and Functions of Human T Lymphocytes

1978 • 184 citations

Recent Experience with Bacillemia Due to Gram-Negative Organisms

1971 • 156 citations

Failure to respond to influenza vaccine in the aged: correlation with B-cell number and function.

1978 • 130 citations

Immunologic theory of aging: current status.

1974 • 129 citations

Humoral immunity in aged mice. II. Increased suppressor T cell activity in immunologically deficient old mice.

1976 • 124 citations

Influence of the main histocompatibility complex on ageing in mice

1977 • 120 citations

Ageing and Immunological Function in Man

1972 • 118 citations

Immunobiology of aging: Evaluation of current status

1976 • 115 citations

Cytokinetic analysis of the impaired proliferative response of peripheral lymphocytes from aged humans to phytohemagglutinin.

1979 • 112 citations

Temperature as a Factor in Resistance of Young Puppies to Canine Herpesvirus

1969 • 109 citations

INFLUENZA VACCINATION AND MORTALITY FROM BRONCHOPNEUMONIA IN THE ELDERLY

1975 • 107 citations

Aging and the immune response. I. Antibody formation and chronic infection in Toxoplasma gondii-infected mice.

1978 • 104 citations

Host Defenses in the Aged: Evaluation of Components of the Inflammatory and Immune Responses

1978 • 103 citations

The physiology of aging.

1962 • 102 citations

Effect of age on cell-mediated immunity in long-lived mice.

1975 • 93 citations

FEVER AS A MECHANISM OF RESISTANCE

1960 • 91 citations

In Vitro Immune Response to the 2,4,6-Trinitrophenyl Determinant in Aged C57BL/6J Mice: Changes in the Humoral Immune Response to, Avidity for the TNP Determinant and Responsiveness to LPS Effect with Aging

1976 • 89 citations

Age-Related Changes in T Cell Function

1977 • 85 citations

RELATIVE ANTIBODY-FORMING CAPACITY OF SPLEEN CELLS AS A FUNCTION OF AGE

1962 • 84 citations

Lymphocyte-Mediated Cytotoxicity: Effects of Ageing, Adult Thymectomy and Thymic Factor

1977 • 83 citations

Age-Related Changes in Cell-Mediated Immunity in BALB/C Mice

1975 • 82 citations

Cell-mediated immunity in an ageing population.

1977 • 80 citations

Immune function in aged mice IV. Loss of T cell and B cell function in thymus‐dependent antibody responses

1978 • 80 citations

Prognostic factors in pneumococcal meningitis.

1967 • 76 citations

Reduced humoral immune activity in long-lived old mice: an approach to elucidating its mechanisms.

1976 • 69 citations

Bacterial endocarditis in subjects 60 years of age and older.

1975 • 67 citations

The Decline of Cell-mediated Immunity in Aging Mice

1974 • 63 citations

Aging and the Respiratory System

1976 • 62 citations

Presence of Impairment of Humoral Immunity in Nonadherent Spleen Cells of Old Mice

1973 • 62 citations

Age-dependent variations in polymorphonuclear leukocyte chemiluminescence

1978 • 60 citations

Change of Cell-Mediated Cytotoxicity with Aging

1975 • 59 citations

Cell-mediated immunity and aging.

1974 • 57 citations

Autoimmunity and Aging: The Age-Related Response of Mice of a Long-Lived Strain to Trinitrophenylated Syngeneic Mouse Red Blood Cells

1976 • 56 citations

Lymphocyte responses to phytohaemagglutinin: age-related effects.

1976 • 56 citations

Age-related decline in the resistance of mice to infection with intracellular pathogens

1977 • 54 citations

Pathology of the Aged

1965 • 54 citations

Immunological senescence. I. The role of suppressor cells.

1978 • 48 citations

Immune responses in aged mice.

1969 • 48 citations

Aging and Cancerigenesis. I. Immunity to Tumor and Skin Grafts<xref ref-type="fn" rid="FN2">2</xref>

1964 • 46 citations

Humoral immunity in aging.

1974 • 41 citations

Aging and the immune response. II. Lymphocyte responsiveness and macrophage activation in Toxoplasma gondii-infected mice.

1978 • 38 citations

Humoral immunity in aged mice. I. Age-related decline in the secondary response to DNP of spleen cells propagated in diffusion chambers.

1976 • 38 citations

IMMUNE RESPONSE IN AGED MICE

1973 • 37 citations

Increased proliferative response of human peripheral blood lymphocytes to anti-immunoglobulin antibodies in elderly people

1978 • 37 citations

Age-Associated Decline in the in Vitro Development of Cytotoxic Lymphocytes in NZB Mice

1976 • 36 citations

Ageing Does Not Change Blood Granulocyte Bactericidal Capacity and Levels of Complement Factors 3 and 4

1978 • 35 citations

Age-Related Defense against Infection with Intracellular Pathogens

1979 • 33 citations

The Quantitative Production of Interferon by Mitogen-Stimulated Mouse Lymphocytes as a Function of Age and Its Effect on the Lymphocytes Proliferative Response

1977 • 33 citations

Immune function in aged mice III. Role of macrophages and effect of 2‐mercaptoethanol in the response of spleen cells from old mice to phytohemagglutinin, lipopolysaccharide and allogeneic cells

1978 • 33 citations

Investigation of host defense mechanisms in the aged as determinants of nosocomial colonization and pneumonia.

1978 • 33 citations

Age-related changes in the cellular immune response of lymph node and thymus cells in long-lived mice

1975 • 32 citations

Aging and Cancerigenesis. II. Effect of Age on Phagocytic Activity of the Reticuloendothelial System and on Tumor Growth2

1965 • 30 citations

A multiple-parameter comparison of immunocompetence and tumor resistance in aged BALB/c mice

1977 • 28 citations

Senescent loss of resistance to murine sarcoma virus (Moloney) in the mouse.

1973 • 27 citations

Immune reactivity during aging. I. T-helper dependent and independent antibody responses to different antigens, in vivo and in vitro

1978 • 26 citations

Increased incidence of lymphomas in thymectomized Mice - evidence for an immunological theory of aging

1972 • 26 citations

Clearance of foreign red cells from the blood of aging mice

1973 • 25 citations

Immune reactivity during aging. II. Analysis of the cellular mechanisms involved in the deficient antibody response in old mice

1978 • 25 citations

Macrophage-mediated natural cytotoxicity against various target cells in vitro. II. Macrophages from rats of different ages

1978 • 24 citations

Model Approach to Immunological Rejuvenation of the Aged

1972 • 24 citations

Serological Response of Japanese Children and Old People to Japanese B Encephalitis Mouse Brain Vaccine

1947 • 22 citations

Age-dependent macrophage functions in New Zealand Black mice

1979 • 22 citations

Cytoplasmic Hepatitis B Surface Antigen and the Ground-glass Appearance in Hepatocellular Carcinoma

1979 • 22 citations

Age-associated involution of cellular immune function. I. Accelerated decline of mitogen reactivity of spleen cells in adult thymectomized mice.

1976 • 21 citations

Cause and Control of Fatal, Infantile Diarrheal Diseases *

1963 • 20 citations

Effect of age on phagocytosis of carbon in the rat

1973 • 19 citations

Decreased Resistance to Trichinella spiralis in Aged Mice

1975 • 18 citations

Effect of age and sex on lung-colony-forming efficiency of injected mouse tumour cells

1976 • 17 citations

Age related decline in cytoplasmic spreading of mouse peritoneal macrophages

1978 • 16 citations

THE EFFECT OF EXTERNAL TEMPERATURE ON THE COURSE OF INFECTIOUS MYXOMATOSIS OF RABBITS

1942 • 16 citations

BACTERIAL ENDOCARDITIS IN THE AGED

1955 • 15 citations

Renal Disease in the Elderly

1976 • 13 citations

Aging and the regulation of immune reactivity

1975 • 11 citations

Relationship between lymphocyte response to tetanus toxoid and age of lymphocyte donor

1978 • 11 citations

Arthritis in the Elderly: An Overview

1976 • 7 citations

Disorders of Hemostasis and Thrombosis in the Aged

1976 • 6 citations

Characterization of the blastogenic response of C58 spleen cells: age-dependent changes.

1974 • 5 citations

Altersabh�ngigkeit immunologischer Untersuchungsverfahren zur Feststellung einer Immundefizienz

1978 • 4 citations

Neutrophilic Turnover Rate in Human Age Groups Evaluated by Serum Lysozyme Activity

1978 • 4 citations

Natural antibody level in old age.

1978 • 3 citations

Interaction of host and cancer: the potential antigenicity of cancer cells, the defense mechanisms of cancer patients, and the influence of endocrine glands and aging on cancer.

1970 • 1 citations