Antagonism between PTEN/MMAC1/TEP-1 and Androgen Receptor in Growth and Apoptosis of Prostatic Cancer Cells

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 3,053 citations

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

1994 • 2,875 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

Pten is essential for embryonic development and tumour suppression

1998 • 1,507 citations

Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN

1998 • 1,215 citations

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

1998 • 1,180 citations

Crystal Structure of the PTEN Tumor Suppressor

1999 • 1,011 citations

Cloning of Human Androgen Receptor Complementary DNA and Localization to the X Chromosome

1988 • 1,007 citations

Cancer statistics, 1993

1993 • 983 citations

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1998 • 823 citations

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

1999 • 787 citations

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase

1996 • 631 citations

Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.

1996 • 627 citations

From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells

1999 • 587 citations

Proteasome-dependent degradation of the human estrogen receptor

1999 • 573 citations

Regulation of G₁progression by thePTENtumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

1999 • 572 citations

Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors.

1988 • 530 citations

Characterization and expression of a cDNA encoding the human androgen receptor.

1989 • 483 citations

Activation of the Human Androgen Receptor through a Protein Kinase A Signaling Pathway

1996 • 430 citations

Cloning, structure and expression of a cDNA encoding the human androgen receptor

1988 • 371 citations

Interaction between the Amino- and Carboxyl-terminal Regions of the Rat Androgen Receptor Modulates Transcriptional Activity and Is Influenced by Nuclear Receptor Coactivators

1997 • 370 citations

Reduced transcriptional regulatory competence of the androgen receptor in X–linked spinal and bulbar muscular atrophy

1993 • 354 citations

Antagonistic effect of androgen on prostatic cell death

1984 • 339 citations

Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN.

1999 • 275 citations

Identification of three proline-directed phosphorylation sites in the human androgen receptor.

1995 • 174 citations

Androgens induce resistance to bcl-2-mediated apoptosis in LNCaP prostate cancer cells.

1995 • 154 citations

Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of phosphatidylinositol 3'-kinase and Akt/protein kinase B.

1999 • 144 citations

Differential transactivation by the androgen receptor in prostate cancer cells

1998 • 50 citations

Phosphorylation of Ser211 in the Chicken Progesterone Receptor Modulates its Transcriptional Activity

1996 • 41 citations

?Decoy? of androgen-responsive element induces apoptosis in LNCaP cells

1999 • 32 citations

Molecular cloning and characterization of a human protein kinase that specifically activates c-Jun N-terminal kinase

1998 • 29 citations

Phosphorylation and Steroid Hormone Action

1995 • 27 citations