Emergence of nitrosourea resistant sublines of Lewis lung tumour following MeCCNU treatment in vivo

A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate.

1979 • 1,331 citations

DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

1980 • 315 citations

Repair of O⁶-methylguanine in DNA by demethylation is lacking in Mer⁻ human tumor cell strains

1983 • 140 citations

Cross-linking of DNA induced by chloroethyinitrosourea is prevented by O⁶-methyiguanine-DNA methyttransferase

1983 • 137 citations

A soft agar colony assay for Lewis lung tumour and B16 melanoma taken directly from the mouse

1976 • 135 citations

O6-Methylguanine-DNA methyltransferase of human lymphoid cells: structural and kinetic properties and absence in repair-deficient cells.

1983 • 125 citations

Suppression of cross-link formation in chloroethylnitrosourea-treated DNA by an activity in extracts of human leukemic lymphoblasts.

1984 • 97 citations

Repopulation of γ-irradiated Lewis lung carcinoma by malignant cells and host macrophage progenitors

1978 • 96 citations

Defective removal of DNA cross-links in a repair-deficient mutant of Chinese hamster cells.

1982 • 91 citations

Experimental therapeutics and kinetics: selection and overgrowth of specifically and permanently drug-resistant tumor cells.

1978 • 65 citations

Mutagenicity and cytotoxicity of various nitrosoureas in V-79 Chinese hamster cells.

1980 • 43 citations

Cell yield and cell survival following chemotherapy of the B16 melanoma

1978 • 34 citations

Development of drug resistance in a murine mammary tumour

1985 • 29 citations

Mutagenic activity of nitrosourea antitumor agents.

1980 • 21 citations

Induced and inherent resistance to alkylating agents in human small-cell bronchial carcinoma xenografts

1984 • 18 citations

Identification of a subpopulation of MeCCNU resistant cells in previously untreated Lewis lung tumours

1984 • 17 citations

A quick reference chart on cross resistance between anticancer patients.

1972 • 13 citations