Biological response of multicellular emt6 spheroids to exogenous lactate

Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model

1988 • 1,755 citations

SELF-REGULATION OF GROWTH IN THREE DIMENSIONS

1973 • 811 citations

Identification of ketone bodies and glutamine as the major respiratory fuels in vivo for postabsorptive rat small intestine.

1978 • 472 citations

Multicellular spheroids

1987 • 427 citations

Characteristics of a Serially Transplanted Mouse Mammary Tumor and Its Tissue-Culture-Adapted Derivative

1972 • 411 citations

Regulation of growth saturation and development of necrosis in EMT6/Ro multicellular spheroids by the glucose and oxygen supply.

1986 • 319 citations

Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts.

1989 • 266 citations

Oxygenation and differentiation in multicellular spheroids of human colon carcinoma.

1986 • 240 citations

Selective dissociation and characterization of cells from different regions of multicell tumor spheroids.

1980 • 202 citations

A reduction in the in situ rates of oxygen and glucose consumption of cells in EMT6/Ro spheroids during growth

1985 • 186 citations

Influence of glucose and oxygen supply conditions on the oxygenation of multicellular spheroids

1986 • 177 citations

Role of necrosis in regulating the growth saturation of multicellular spheroids.

1988 • 167 citations

Formation and growth of multicellular spheroids of human origin

1983 • 154 citations

Method for the determination of oxygen consumption rates and diffusion coefficients in multicellular spheroids

1984 • 140 citations

Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: potential implications for cell death in tumors.

1986 • 130 citations

Lactate: A major product of glutamine metabolism by human diploid fibroblasts

1980 • 119 citations

Proliferative and clonogenic heterogeneity of cells from EMT6/Ro multicellular spheroids induced by the glucose and oxygen supply.

1986 • 106 citations

Importance of critical metabolites and cellular interactions in the biology of microregions of tumors

1986 • 104 citations

Diffusion regulated growth characteristics of a spherical prevascular carcinoma.

1990 • 101 citations

Distributions of oxygen, nutrient, and metabolic waste concentrations in multicellular spheroids and their dependence on spheroid parameters

1991 • 97 citations

RESPONSES OF CELLS TO pH CHANGES IN THE MEDIUM

1962 • 95 citations

Influence of convection in the growth medium on oxygen tensions in multicellular tumor spheroids.

1982 • 93 citations

The relation between glucose utilization, lactic acid production and utilization and the growth cycle of L strain fibroblasts

1959 • 86 citations

The influence of oxygen on viability and proliferation in cellular spheroids

1979 • 85 citations

Growth of mammalian multicellular tumor spheroids.

1983 • 83 citations

Ketone body, glucose, lactic acid, and amino acid utilization by tumors in vivo in fasted rats.

1983 • 80 citations

A model for the growth of multicellular spheroids

1982 • 76 citations

Cellular growth and metabolic adaptations to nutrient stress environments in tumor microregions

1986 • 52 citations

Radiation survival of cells from spheroids grown in different oxygen concentrations.

1979 • 50 citations

Influence of glucose concentration on growth and formation of necrosis in spheroids derived from a human bladder cancer cell line.

1986 • 47 citations

Radiation Survival of Cells from Spheroids Grown in Different Oxygen Concentrations

1979 • 37 citations

Lactate-induced inhibition of tumor cell proliferation

1988 • 34 citations

Atemgaswechsel und Glucosestoffwechsel von Tumoren (DS-Carcinosarkom) in vivo

1971 • 25 citations

Lactate and pyruvate metabolism and reducing equivalent transfer in Ehrlich ascites tumor.

1974 • 25 citations

Partial purification of a protein growth inhibitor from multicellular spheroids

1988 • 21 citations

Variation of pO2 in the growth medium of spheroids: Interaction with glucose to influence spheroid growth and necrosis

1986 • 20 citations

Metabolitanalysen bei schnell wachsenden DS-Carcinosarkomen der H�hner-Chorioallantois

1969 • 4 citations