Importance of critical metabolites and cellular interactions in the biology of microregions of tumors

Growth of Multicell Spheroids in Tissue Culture as a Model of Nodular Carcinomas<xref ref-type="fn" rid="FN2">2</xref>

1971 • 580 citations

Regulation of growth saturation and development of necrosis in EMT6/Ro multicellular spheroids by the glucose and oxygen supply.

1986 • 319 citations

Effects of intercellular contact on repair of radiation damage

1972 • 287 citations

Induction of glucose-regulated proteins during anaerobic exposure and of heat-shock proteins after reoxygenation.

1984 • 229 citations

Resistance to adriamycin in multicellular spheroids

1979 • 227 citations

Selective dissociation and characterization of cells from different regions of multicell tumor spheroids.

1980 • 202 citations

Characteristics of the metabolism-induced binding of misonidazole to hypoxic mammalian cells.

1983 • 187 citations

A reduction in the in situ rates of oxygen and glucose consumption of cells in EMT6/Ro spheroids during growth

1985 • 186 citations

Influence of glucose and oxygen supply conditions on the oxygenation of multicellular spheroids

1986 • 177 citations

Growth and Cellular Characteristics of Multicell Spheroids

1984 • 163 citations

Binding to cellular macromolecules as a possible mechanism for the cytotoxicity of misonidazole.

1980 • 161 citations

Tumor cell heterogeneity : origins and implications

1982 • 159 citations

Limited penetration of methotrexate into human osteosarcoma spheroids as a proposed model for solid tumor resistance to adjuvant chemotherapy.

1980 • 155 citations

Penetration and binding of radiolabeled anti-carcinoembryonic antigen monoclonal antibodies and their antigen binding fragments in human colon multicellular tumor spheroids.

1987 • 150 citations

Flow cytometry studies of intracellular adriamycin in multicell spheroids in vitro.

1981 • 134 citations

Intracapillary oxyhemoglobin saturation of malignant tumors in humans

1981 • 131 citations

Oxygen tensions in multicell spheroids of two cell lines

1982 • 129 citations

Induction characteristics of oxygen regulated proteins

1986 • 121 citations

Use of Hoechst 33342 for cell selection from multicell systems.

1982 • 120 citations

Hyperthermia in cancer therapy: the biological basis and unresolved questions.

1985 • 116 citations

Proliferative and clonogenic heterogeneity of cells from EMT6/Ro multicellular spheroids induced by the glucose and oxygen supply.

1986 • 106 citations

In situ oxygen consumption rates of cells in V‐79 multicellular spheroids during growth

1984 • 103 citations

The effects of glucose on protein synthesis and thermosensitivity in Chinese hamster ovary cells.

1983 • 103 citations

Cytotoxicity of adriamycin in MGH-U1 cells grown as monolayer cultures, spheroids, and xenografts in immune-deprived mice.

1984 • 95 citations

Increased radioresistance of cells in cultured multicell spheroids. I. Dependence on cellular interaction

1981 • 91 citations

Isolation of quiescent cells from multicellular tumor spheroids using centrifugal elutriation.

1982 • 69 citations

Heterogeneous Oxygenation of Rectal Carcinomas in Humans: A Critical Parameter for Preoperative Irradiation?

1984 • 68 citations

Metabolism induced binding of 4C-misonidazole to hypoxic cells: Kinetic dependence on oxygen concentration and misonidazole concentration

1984 • 62 citations

Cellular growth and metabolic adaptations to nutrient stress environments in tumor microregions

1986 • 52 citations

The Effect of Intercellular Contact on the Radiation Sensitivity of KHT Sarcoma Cells

1979 • 48 citations

Intracapillary HbO2 saturation in malignant tumors during normoxia and hyperoxia

1979 • 48 citations

Resistance to vincristine of human cells grown as multicellular spheroids

1980 • 42 citations

Effects of Hyperthermia on the Cycling, Noncycling, and Hypoxic Cells of Irradiated and Unirradiated Multicell Spheroids

1978 • 40 citations

Oxygen Transport to Tissue

1973 • 36 citations

Spheroids for Studies of Drug Effects

1984 • 35 citations

Increased thermoresistance developed during growth of small multicellular spheroids

1985 • 34 citations

Binding of misonidazole to EMT6 AND V79 spheroids

1982 • 32 citations

Effect of Intercellular Contact on DNA Conformation, Radiation-Induced DNA Damage, and Mutation in Chinese Hamster V79 Cells

1985 • 31 citations

Radiobiological Studies of Cells in Multicellular Spheroids Using a Sequential Trypsinization Technique

1981 • 25 citations

Intercellular Communication in Spheroids

1984 • 25 citations

Influences of growth conditions and cell-cell contact on responses of tumor cells to ultrasound.

1981 • 23 citations

Further Characterization of 4-Bromomisonidazole as a Potential Detector of Hypoxic Cells

1985 • 22 citations

Influences of Growth Conditions and Cell-Cell Contact on Responses of Tumor Cells to Ultrasound

1981 • 18 citations

Decreased hypoxic toxicity and binding of misonidazole by low glucose concentration

1986 • 15 citations

Retinoic acid restores shape‐dependent growth control in neoplastic cells cultured on poly(2‐hydroxyethyl methacrylate)‐coated substrate

1984 • 11 citations

Deleted Work

1955 • 0 citations