The Influence of Stereochemical Factors on Drug Disposition

Enzymatic O-Methylation of Epinephrine and Other Catechols

1958 • 1,291 citations

Decarboxylase Inhibition and Blood Pressure Reduction by α-Methyl-3,4-Dihydroxy-DL-phenylalanine

1960 • 254 citations

Increased Activity of Androgen Hydroxylases in Liver Microsomes of Rats Pretreated with Phenobarbital and Other Drugs

1963 • 250 citations

The metabolic fate of amphetamine in man and other species

1970 • 247 citations

Inhibition of dihydroxyphenylalanine decarboxylase by derivatives of phenylalanine

1954 • 222 citations

Fermentativer Abbau von l-Dioxyphenylalanin (Dopa) durch Niere

1938 • 217 citations

Urinary excretion kinetics of amphetamine in man

1965 • 207 citations

THE ENZYMATIC DEAMINATION OF AMPHETAMINE (BENZEDRINE)

1955 • 204 citations

The pharmacology and biochemistry of N-oxides.

1969 • 193 citations

The metabolic conversion of 5, 5-diphenyl hydantoin to 5-(p-hydroxyphenyl)-5-phenyl hydantoin.

1957 • 151 citations

METHYLDOPA IN HYPERTENSION CLINICAL AND PHARMACOLOGICAL STUDIES

1962 • 130 citations

Possible Mechanism of Tolerance to Narcotic Drugs

1956 • 112 citations

Reductase for Aromatic Aldehydes and Ketones

1968 • 105 citations

The conversion in vivo of d-amphetamine to (+)-p-hydroxynorephedrine

1965 • 102 citations

THE STEREOCHEMISTRY OF 7α-HYDROXYLATION IN THE BIOSYNTHESIS OF CHOLIC ACID FROM CHOLESTEROL

1958 • 99 citations

A new metabolite of 5,5-diphenylhydantoin (Dilantin++Dilantin is the Parke-Davis trade name for 5,5-diphenylhydatoin (phenytoin).)

1970 • 92 citations

The metabolic fate of diphenylhydantoin in the dog, rat and man.

1960 • 91 citations

Metabolic Oxidation of Aliphatic Basic Nitrogen Atoms and their α-Carbon Atoms

1971 • 91 citations

Relationships Between Stereostructure and Pharmacological Activities

1970 • 91 citations

Urinary Excretion of Methylamphetamine in Man

1965 • 80 citations

A comparison of the isomers of warfarin

1966 • 79 citations

Substrate specificity of amino-acid decarboxylases

1950 • 79 citations

Correlation of partition coefficients in n-heptane-aqueous systems with buccal absorption data for a series of amines and acids

1969 • 76 citations

The enzymatic demethylation of ephedrine.

1955 • 75 citations

Metabolism of barbiturates in man

1963 • 72 citations

The fate of radiocarbon-labeled propoxyphene in rat, dog, and human

1971 • 72 citations

Rhythmic Urinary Excretion of Amphetamine in Man

1964 • 72 citations

The Preparation of cis- and trans-4-H³-L-Prolines and Their Use in Studying the Mechanism of Enzymatic Hydroxylation in Chick Embryos

1964 • 67 citations

Enzymic oxidation of (—)-nicotine by guinea-pig tissues in vitro

1971 • 67 citations

The urinary output of d- and l-amphetamine in man

1967 • 66 citations

The mechanism of oxidation of amphetamine enantiomorphs by liver microsomal preparations from different species

1972 • 66 citations

Metabolism and Cytochrome P-450 Binding Spectra of (+)- and (—)-Hexobarbital in Rat Liver Microsomes

1969 • 64 citations

The metabolism of glutethimide (Doriden®)

1962 • 64 citations

Structure of hydroxycotinine, a nicotine methobolite

1972 • 62 citations

Persistence of Methadone-3H and Metabolite in Rat Brain after a Single Injection and its Implications on Pharmacological Tolerance

1972 • 62 citations

Elements of stereoisomerism and prostereoismerism

1971 • 61 citations

The plasma half lives and the pharmacological effect of the enantiomers of warfarin in rats

1972 • 60 citations

The metabolites of cyclohexylamine in man and certain animals

1972 • 60 citations

Metabolic N- and O-demethylation of morphine- and morphinan-type analgesics.

1958 • 60 citations

The metabolism of nicotine into two optically-active stereoisomers of nicotine-1′-oxide by animal tissues in vitro and by cigarette smokers

1970 • 59 citations

Studies in detoxication. 56. The metabolism of alkylbenzenes. Stereochemical aspects of the biological hydroxylation of ethylbenzene to methylphenylcarbinol

1954 • 58 citations

The microsomal oxygenation of ethyl benzene: Isotopic, stereochemical, and induction studies

1969 • 58 citations

Some Aspects of the Fate and Relationship of the N-Methyl Group of Morphine to its Pharmacological Activity^1a

1963 • 57 citations

ETHYL(3-HYDROXY-1-METHYLBUTYL)BARBITURIC ACIDS AS METABOLITES OF PENTOBARBITAL

1952 • 53 citations

Identification of 5-meta-Hydroxyphenyl-5-phenylhydantoin as a metabolite of diphenylhydantoin

1970 • 53 citations

The metabolism of14C-labelled α-methyldopa in normal and hypertensive human subjects

1972 • 52 citations

Metabolism in vitro and in vivo of pentazocine

1969 • 49 citations

Methamphetamine, fenfluramine and their N-dealkylated metabolites: effect on monoamine concentrations in rat tissues.

1972 • 49 citations

Differences in anaesthetic properties between the optical antipodes of hexobarbital in the rat

1966 • 47 citations

Norephedrines as metabolites of [14C]amphetamine in urine in man

1972 • 46 citations

Metabolism of diazepam in vitro

1968 • 43 citations

Biological Oxidation of Nitrogen in Organic Molecules

1971 • 43 citations

Stereoselective metabolism of the enantiomers of hexobarbital.

1969 • 41 citations

Stereospecificity of anesthetic activity, distribution, inactivation and protein binding of the optical antipodes of two N-methylated barbiturates.

1970 • 40 citations

Species Variation in the Metabolism of R-(+)- and S-(-)-Nicotine by α-C- andN-Oxidationin vitro

1973 • 39 citations

Microsomal hydroxylation of ethylbenzene. Stereospecificity and the effect of phenobarbital induction

1966 • 39 citations

The relation between biological activity and the degree of resolution of optical isomers

1972 • 38 citations

Analgesic activity and central nervous system distribution of the optical isomers of pentazocine in the rat.

1971 • 37 citations

Studies in detoxication. 59. The metabolism of alkylbenzenes. The biological reduction of ketones derived from alkylbenzenes

1954 • 35 citations

Stereoselective metabolism of amphetamine

1967 • 35 citations

Effects of Deficiencies of Pyridoxine, Riboflavin and Thiamine upon the Catecholamine Content of Rat Tissues

1960 • 35 citations

The metabolism in vitro and hepatic microsomal interactions of some enantiomeric drug substrates

1970 • 34 citations

Metabolism and excretion of diethylpropion in man under acidic urine conditions

1973 • 34 citations

Vergleich von verteilung, narkotischer wirksamkeit und metabolischer elimination der optischen antipoden von methylphenobarbital

1968 • 34 citations

Factors Affecting thein vitroMetabolism of R-(+)-and S-(-)-Nicotine by Guinea-pig Liver Preparations

1973 • 31 citations

Urinary excretion of the drug and its main metabolite in man, after the administration of (±)-, (+)- and (-)-ethylamphetamine

1969 • 30 citations

Amphetamine excretion studies in man

1961 • 30 citations

The plasma half-lives of the enantiomers of warfarin in warfarin-resistant and warfarin-susceptible rats

1972 • 28 citations

Identification of three new metabolites of methadone in man and in the rat

1972 • 28 citations

A pharmacological comparison of the optical isomers of 5-ethyl-5-phenyl hydantoin (nirvanol) and of 3-methyl-5-ethyl-5-phenyl hydantoin (mesantoin).

1954 • 27 citations

Metabolism of 3, 4-dihydroxyphenylalanine by isolated perfused rat liver

1971 • 27 citations

The stereospecificity of the enzymatic amphetamine β-hydroxylation

1964 • 27 citations

STEREOCHEMICAL ASPECTS OF THE METABOLISM OF THE ISOMERIC METHYLCYCLOHEXANOLS AND METHYLCYCLOHEXANONES

1965 • 26 citations

815. The configuration of noradrenaline

1959 • 25 citations

Metabolic demethylation of 3-methyl-5-ethyl-5-phenyl hydantoin (Mesantoin).

1952 • 24 citations

Oxidation of indan to indanol and indanone by the hepatic microsomal system

1970 • 24 citations

THE DETOXICATION AND EXCRETION OF BETA PHENYLISOPROPYLAMINE (BENZEDRINE)

1940 • 23 citations

Stereoselectivity and Differential Metabolism in vivo of Dextro and Laevo-Methadone-1-3H

1973 • 23 citations

The metabolism of R(+)- and RS-pentobarbital.

1969 • 22 citations

The in vitro and in vivo metabolism of optically active methylcyclohexanols and methylcyclohexanones

1969 • 22 citations

Demethylation of N-methyl derivatives of barbituric acid, hydantoin, and 2,4-oxazolidinedione by rat liver microsomes

1963 • 22 citations

Metabolic fates of 3-ethyl-5-phenylhydantoin (ethotoin, peganone), 3-methyl-5-phenylhydantoin and 5-phenylhydantoin.

1970 • 21 citations

Pathways of medazepam metabolism in the dog and rat.

1972 • 19 citations

Studies on the metabolism of diethylpropion

1972 • 18 citations

Metabolism of optically active barbiturates. II. S (-)--pentobarbital.

1970 • 18 citations

Kinetic differences in the microsomal metabolism of the isomers of hexobarbital.

1971 • 18 citations

The influence of methyl substitution on the N-demethylation and N-oxidation of normethadone in animal species

1971 • 18 citations

On the metabolism of prenylamine (segontin®)

1968 • 18 citations

Konfiguration, biogenese und stoffwechsel von 6α- und 6β-hydroxylierten phenolischen steroiden

1962 • 17 citations

On the β-hydroxylation of (±)-α-methyldopamine in vivo

1968 • 17 citations

Characterization of the Diastereoisomers of Nicotine-1′-N-Oxide, a Metabolite of Nicotine, and Other Possible Oxidation Products by Nuclear Magnetic Resonance Spectroscopy

1973 • 17 citations

Analytical and pharmacokinetic studies on the optic isomers of oxazepam succinate half-ester

1972 • 16 citations

The physiological disposition of ¹⁴C‐methsuximide in the rat

1972 • 15 citations

Synthesis and Relative Urinary Excretion Rates of the Enantiomers of Warfarin-4-¹⁴C and Phenprocoumon-2-¹⁴C

1969 • 15 citations

Stereochemical studies on medicinal agents. 11. Metabolism and distribution of prodine isomers in mice

1972 • 14 citations

Spectropolarimetry III. Determination of the absolute configuration of some phenylethylamino derivatives

1964 • 14 citations

Metabolic fates of N-methyl- -phenylsuccinimide (phensuximide, milontin) and of -phenylsuccinimide in the dog.

1972 • 11 citations

On the role of molecular chirality in biological electron transport and luminescence

1971 • 11 citations

Biotransformation of diphenoxylate in rat and dog.

1971 • 10 citations

The microsomal N-demethylation of the stereoisomers of ephedrine

1971 • 9 citations

On the stereospecificity of the β-hydroxylation of α-methyldopamine

1968 • 9 citations

THE MICROSOMAL HYDROXYLATION OF ETHYLBENZENE STEREOCHEMICAL, INDUCTION AND ISOTOPIC STUDIES

1969 • 8 citations

Metabolism of o-hydroxy-<scp>L</scp>- and o-hydroxy-<scp>D</scp>-phenylalanine-2-¹⁴C in the rat

1969 • 6 citations

Tierexperimentelle Untersuchungen mit α-Methyl-Dopa-¹⁴C unter besonderer Berücksichtigung der optischen Isomeren

1965 • 6 citations

The excretion of amphetamine.

1947 • 5 citations

Metabolism of diazepam metabolites in guinea pigs

1972 • 5 citations

The concept of dissymmetric worlds. A utilization of the power of optical isomerism

1972 • 4 citations