Metabolic stereoisomeric inversion of 2-arylpropionic acids. On the mechanism of ibuprofen epimerization in rats

The metabolic chiral inversion of 2-arylpropionic acids—a novel route with pharmacological consequences

1983 • 395 citations

The metabolic chiral inversion and dispositional enantioselectivity of the 2-arylpropionic acids and their biological consequences

1988 • 383 citations

[137] Preparation and assay of acyl coenzyme A and other thiol esters; use of hydroxylamine

1957 • 354 citations

Stereoselective disposition of ibuprofen enantiomers in man.

1985 • 253 citations

A facile enzymatic resolution process for the preparation of (+)--2-(6-hethoxy-2-naphthyl)propionic acid (Naproxen).

1986 • 134 citations

Enzymatic inversion at saturated carbon: Nature and mechanism of the inversion of R(−) p-iso-butyl hydratropic acid

1974 • 133 citations

β-Hydroxydecanoyl Thioester Dehydrase

1967 • 116 citations

Chiral aspects of drug metabolism

1986 • 100 citations

Pharmacokinetics of ibuprofen enantiomers in humans following oral administration of tablets with different absorption rates.

1988 • 92 citations

Mechanistic studies of the metabolic chiral inversion of (R)-ibuprofen in humans.

1989 • 86 citations

Stereospecific inversion of (R)-(−)-benoxaprofen in rat and man

1980 • 78 citations

Basis and current scope of rational anti-inflammatory therapy

1985 • 72 citations

Metabolism of Propionic Acid in Animal Tissues

1962 • 71 citations

The metabolic chiral inversion of 2-phenylpropionic acid in rat, mouse and rabbit

1986 • 64 citations

Pharmacokinetic analysis of the enantiomeric inversion of chiral nonsteroidal antiinflammatory drugs.

1988 • 56 citations

Ibuprofen stereoisomer hepatic clearance and distribution in normal and fatty in situ perfused rat liver.

1985 • 54 citations

Xenobiotic acyl-coenzymes A: critical intermediates in the biochemical pharmacology and toxicology of carboxylic acids

1984 • 53 citations

Effects of smooth muscle relaxant (Aspaminol) on Ca-uptake by mitochondrial and microsomal fractions from rat uterus.

1981 • 40 citations

Ester enolates from .alpha.-acetoxy esters. Synthesis of arylmalonic and .alpha.-arylalkanoic esters from aryl nucleophiles and .alpha.-keto esters

1982 • 35 citations

Symmetry and asymmetry in mandelate racemase catalysis

1985 • 30 citations

Stereoselective metabolism of 2-phenylpropionic acid in rat. II. Studies on the organs responsible for the optical isomerization of 2-phenylpropionic acid in rat in vivo.

1987 • 20 citations

Stereospecific inversion of configuration of 2-(2-isopropylindan-5-yl)-propionic acid in rats.

1980 • 14 citations