Bcl-x and Bax Regulate Mouse Primordial Germ Cell Survival and Apoptosis during Embryogenesis

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.

1996 • 1,124 citations

Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth

1996 • 1,062 citations

An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

1998 • 1,048 citations

Primordial germ cells in the mouse embryo during gastrulation

1990 • 995 citations

Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death.

1993 • 855 citations

Bacteriophage P1 site-specific recombination

1981 • 762 citations

An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis

1997 • 599 citations

Gene‐induced embryological modifications of primordial germ cells in the mouse

1957 • 556 citations

Proliferation and migration of primordial germ cells during compensatory growth in mouse embryos

1981 • 544 citations

Cre-mediated gene deletion in the mammary gland

1997 • 504 citations

bcl-xLx is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria

1994 • 435 citations

Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency

1999 • 368 citations

Expression of members of the bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased bax and constitutive bcl-2 and bcl-xlong messenger ribonucleic acid levels.

1995 • 356 citations

Apoptosis regulator Bcl-w is essential for spermatogenesis but appears otherwise redundant

1998 • 333 citations

Ablation of bcl-2 gene expression decreases the numbers of oocytes and primordial follicles established in the post-natal female mouse gonad.

1995 • 322 citations

Developmentally Regulated Expression of a Mouse Germ Cell Nuclear Antigen Examined from Embryonic Day 11 to Adult in Male and Female Mice

1994 • 269 citations

Expression and regulation of genes associated with cell death during murine preimplantation embryo development

1998 • 267 citations

Testicular degeneration in Bclw-deficient mice

1998 • 263 citations

Calendar of Gametogenic Development in the Prepuberal Male Mouse

1961 • 253 citations

Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles

1998 • 209 citations

X-chromosome activity in foetal germ cells of the mouse

1981 • 208 citations

Evidence That the Mechanism of Prenatal Germ Cell Death in the Mouse Is Apoptosis

1993 • 203 citations

Bcl-xS Antagonizes the Protective Effects of Bcl-xL

1996 • 200 citations

Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene.

1997 • 188 citations

Role of mitochondria and C‐terminal membrane anchor of Bcl‐2 in Bax induced growth arrest and mortality in Saccharomyces cerevisiae

1996 • 178 citations

Migration of gonocytes into the mammalian gonad and their differentiation

1970 • 177 citations

Fine structural observations on the origin and associations of primordial germ cells of the mouse

1975 • 175 citations

Autonomous Cell Death of Mouse Male Germ Cells during Fetal and Postnatal Period1

1998 • 175 citations

Bcl-Xl– and Bax-–Mediated Regulation of Apoptosis of Human Neutrophils Via Caspase-3

1999 • 174 citations

Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice.

1997 • 166 citations

Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe.

1997 • 160 citations

A study of the primordial germ cells during their migratory phase in steel mutant mice

1975 • 160 citations

baxDeficiency Prevents the Increased Cell Death of Immature Neurons inbcl-x-Deficient Mice

1997 • 143 citations

Morphological analysis of germ cell apoptosis during postnatal testis development in normal and Hsp70-2 knockout mice

1997 • 130 citations

Origin and migration of primordial germ cells in mammals

1981 • 122 citations

Bax and Bcl-xS are induced at the onset of apoptosis in involuting mammary epithelial cells

1996 • 121 citations

Bcl-Xl– and Bax-–Mediated Regulation of Apoptosis of Human Neutrophils Via Caspase-3

1999 • 84 citations

Oogenesis in the mouse

1967 • 62 citations

Gene Transfection of Mouse Primordial Germ Cellsin Vitroand Analysis of Their Survival and Growth Control

1997 • 61 citations

Delayed myocardial preconditioning by α1-adrenoceptors involves inhibition of apoptosis

1999 • 38 citations

Cre-mediated recombination at the murine whey acidic protein (mWAP) locus

1997 • 21 citations

Seedling Albinism Induced by an Extract of Alternaria tenuis

1961 • 20 citations