Clonal Gene Therapy: Transplanted Mouse Fibroblast Clones Express Human α1-Antitrypsin Gene in Vivo

HUMAN PLASMA PROTEINASE INHIBITORS

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Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

1983 • 1,857 citations

Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution

1986 • 1,093 citations

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Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector

1986 • 761 citations

A restriction enzyme cleavage map of Tn5 and location of a region encoding neomycin resistance

1979 • 577 citations

Prospects for Human Gene Therapy

1984 • 548 citations

Antielastases of the human alveolar structures. Implications for the protease-antiprotease theory of emphysema.

1981 • 441 citations

Effect of internal viral sequences on the utility of retroviral vectors

1987 • 351 citations

Generation of helper-free amphotropic retroviruses that transduce a dominant-acting, methotrexate-resistant dihydrofolate reductase gene.

1985 • 342 citations

Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion

1986 • 290 citations

alpha 1-Antitrypsin: molecular pathology, leukocytes, and tissue damage.

1986 • 276 citations

Replacement therapy of alpha 1-antitrypsin deficiency. Reversal of protease-antiprotease imbalance within the alveolar structures of PiZ subjects.

1981 • 275 citations

MIXED CULTURE CYTOPATHOGENICITY: A NEW TEST FOR GROWTH OF MURINE LEUKEMIA VIRUSES IN TISSUE CULTURE

1969 • 267 citations

Expression of the alpha 1-proteinase inhibitor gene in human monocytes and macrophages.

1985 • 204 citations

Expression of the alpha-1-antitrypsin gene in mononuclear phagocytes of normal and alpha-1-antitrypsin-deficient individuals.

1986 • 178 citations

High-level production of biologically active human alpha 1-antitrypsin in Escherichia coli.

1984 • 136 citations

Retrovirus insertion inactivates mouse α 1(I) collagen gene by blocking initiation of transcription

1986 • 118 citations

Production of glycosylated physiologically "normal" human alpha 1-antitrypsin by mouse fibroblasts modified by insertion of a human alpha 1-antitrypsin cDNA using a retroviral vector.

1987 • 68 citations

A viral long terminal repeat in the interleukin 2 gene of a cell line that constitutively produces interleukin 2.

1985 • 62 citations

Somatic gene therapy. Current status and future prospects.

1986 • 49 citations

A modified double antibody sandwich enzyme-linked immunosorbent assay for measurement of alpha-1-antitrypsin in biologic fluids

1985 • 34 citations