Inflammatory mechanisms in Alzheimer's disease

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

The acute phase response

1994 • 2,927 citations

Diagnosis of Alzheimer's Disease

1985 • 2,482 citations

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

1990 • 2,131 citations

Clinical trial of indomethacin in Alzheimer's disease

1993 • 996 citations

Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

1988 • 899 citations

Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease

1993 • 832 citations

Microglia in degenerative neurological disease

1993 • 594 citations

Inverse association of anti‐inflammatory treatments and Alzheimer's disease

1994 • 567 citations

Interleukin‐6 and α‐2‐macroglobulin indicate an acute‐phase state in Alzheimer's disease cortices

1991 • 484 citations

Interleukin‐6: A Cytokine for Gerontolgists

1993 • 457 citations

Nonsteroidal anti-inflammatory drugs in Alzheimer's disease

1995 • 442 citations

Activation of the classical complement pathway in brain tissue of Alzheimer patients

1989 • 385 citations

Effects of kainic acid on messenger RNA levels of IL-1β, IL-6, TNFα and LIF in the rat brain

1991 • 330 citations

Detection of interleukin-6 and alpha 2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients.

1992 • 329 citations

A COMPARATIVE STUDY OF MODIFIED BIELSCHOWSKY, BODIAN AND THIOFLAVIN S STAINS ON ALZHEIMER'S NEUROFIBRILLARY TANGLES

1986 • 326 citations

Inflammatory mechanisms in Alzheimer's disease: implications for therapy

1994 • 321 citations

Neuropathological staging of Alzheimer lesions and intellectual status in Alzheimer's and Parkinson's disease patients

1993 • 320 citations

Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid

1989 • 259 citations

Neuropathological Indexes of Alzheimer's Disease in Demented and Nondemented Persons Aged 80 Years and Older

1993 • 254 citations

Multiple forms of IFN-beta 2/IL-6 in serum and body fluids during acute bacterial infection.

1989 • 244 citations

Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-1β or IL-1RA but increases in the associated acute phase proteins IL-6, α2-macroglobulin and C-reactive protein

1993 • 243 citations

Interleukin-6 production by astrocytes: Induction by the neurotransmitter norepinephrine

1993 • 181 citations

Interleukin-6 and selected plasma proteins in healthy persons of different ages

1994 • 176 citations

Pathological markers associated with normal aging and dementia in the elderly

1993 • 162 citations

Induction of plasma interleukin-6 by circulating adrenaline in the rat

1994 • 147 citations

Regulation of interleukin-6 (IL-6) secretion in primary cultured rat astrocytes: synergism of interleukin-1 (IL-1) and pituitary adenylate cyclase activating polypeptide (PACAP)

1994 • 132 citations

Interleukin-6 in clinical medicine

1991 • 131 citations

Norepinephrine and vasoactive intestinal peptide induce IL-6 secretion by astrocytes: Synergism with IL-1β and TNFα

1993 • 124 citations

Prevalence of Dementia amongst Elderly Japanese with Leprosy: Apparent Effect of Chronic Drug Therapy

1992 • 111 citations

Temporal Sequence of Plaque Formation in the Cerebral Cortex of Non-Demented Individuals

1993 • 94 citations

Cerebrospinal fluid interleukin-6 activity in HIV infection and inflammatory and noninflammatory diseases of the nervous system

1990 • 64 citations

Interleukin-6 and its receptor during homeostasis, inflammation, and tumor growth

1989 • 52 citations

An In Vivo Study of Phosphorus and Glucose Metabolism in Alzheimer's Disease Using Magnetic Resonance Spectroscopy and PET

1993 • 52 citations

Expression of the α2-macroglobulin-encoding gene in rat brain and cultured astrocytes

1994 • 29 citations