Characterization of a Prostate-specific Tyrosine Phosphatase by Mutagenesis and Expression in Human Prostate Cancer Cells

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

The Molecular Genetics of Cancer

1987 • 1,729 citations

Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases

1997 • 774 citations

Protein tyrosine phosphatases in signal transduction

1997 • 766 citations

Oncoprotein Networks

1997 • 532 citations

From Form to Function: Signaling by Protein Tyrosine Phosphatases

1996 • 526 citations

Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase

1992 • 455 citations

Protein-tyrosine Phosphatase 1B Is a Negative Regulator of Insulin- and Insulin-like Growth Factor-I-stimulated Signaling

1996 • 424 citations

Protein tyrosine phosphatases: mechanisms of catalysis and regulation

1998 • 399 citations

The coordinated action of protein tyrosine phosphatases and kinases in cell signaling

1994 • 342 citations

Evaluation of immunoreactivity for erbB-2 protein as a marker of poor short term prognosis in gastric cancer.

1991 • 331 citations

Epidermal growth factor receptors in non-small cell lung cancer

1987 • 326 citations

PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif

1998 • 313 citations

ErbB2 Potentiates Breast Tumor Proliferation through Modulation of p27^Kip1-Cdk2 Complex Formation: Receptor Overexpression Does Not Determine Growth Dependency

2000 • 304 citations

Direct Binding of the Proline-rich Region of Protein Tyrosine Phosphatase 1B to the Src Homology 3 Domain of p130Cas

1996 • 272 citations

Identification of p130^cas as a Substrate for the Cytosolic Protein Tyrosine Phosphatase PTP-PEST

1996 • 263 citations

Epidermal Growth Factor Receptor and the Adaptor Protein p52^Shc Are Specific Substrates of T-Cell Protein Tyrosine Phosphatase

1998 • 226 citations

Expression of a protein tyrosine phosphatase in normal and v-src-transformed mouse 3T3 fibroblasts

1992 • 176 citations

Protein tyrosine phosphatases in signaling

1996 • 170 citations

Covalent structure, disulfide bonding, and identification of reactive surface and active site residues of human prostatic acid phosphatase

1991 • 164 citations

Form, function, and regulation of protein tyrosine phosphatases and their involvement in human diseases

2000 • 144 citations

Effect of protein tyrosine phosphatase 1B expression on transformation by the human neu oncogene.

1992 • 143 citations

Protein-tyrosine Phosphatase α Regulates Src Family Kinases and Alters Cell-Substratum Adhesion

1998 • 137 citations

Expression of Human Prostatic Acid Phosphatase Correlates with Androgen-stimulated Cell Proliferation in Prostate Cancer Cell Lines

1998 • 137 citations

A phosphotyrosyl‐protein phosphatase activity associated with acid phosphatase from human prostate gland

1984 • 112 citations

Three-dimensional structure of rat acid phosphatase.

1993 • 110 citations

Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of Rat-1 fibroblasts and promotes differentiation of K562 cells

1998 • 100 citations

Human prostatic acid phosphatase has phosphotyrosyl protein phosphatase activity

1986 • 90 citations

Protein Tyrosine Phosphatases: Mechanism of Catalysis and Substrate Specificity

1994 • 88 citations

Protein tyrosine phosphatases: counting the trees in the forest

1998 • 87 citations

Tyrosine Phosphorylation of c-ErbB-2 Is Regulated by the Cellular Form of Prostatic Acid Phosphatase in Human Prostate Cancer Cells

1998 • 86 citations

Crystal Structure of a Human Low Molecular Weight Phosphotyrosyl Phosphatase

1998 • 85 citations

Tyrosine Phosphorylation: Past, Present and Future

1996 • 82 citations

Crystal structure of human prostatic acid phosphatase

2000 • 78 citations

Transformation Suppression by Protein Tyrosine Phosphatase 1B Requires a Functional SH3 Ligand

1998 • 72 citations

Protein tyrosine phosphatases as negative regulators of mitogenic signaling

1999 • 70 citations

Interaction between protein tyrosine phosphatase and protein tyrosine kinase is involved in androgen-promoted growth of human prostate cancer cells

2000 • 69 citations

Expression of human prostatic acid phosphatase activity and the growth of prostate carcinoma cells.

1992 • 65 citations

Soybean Nodule Sucrose Synthase (Nodulin-100): Further Analysis of Its Phosphorylation Using Recombinant and Authentic Root-Nodule Enzymes

1999 • 62 citations

Heterologous expression of human prostatic acid phosphatase and site-directed mutagenesis of the enzyme active site.

1994 • 59 citations

Regulation of Prostatic Acid Phosphatase Expression and Secretion by Androgen in LNCaP Human Prostate Carcinoma Cells

1993 • 52 citations

Studies on the Protein Tyrosine Phosphatase Activity of Tartrate-Resistant Acid Phosphatase

1998 • 52 citations

The epidermal growth factor receptor from prostate cells is dephosphorylated by a prostate-specific phosphotyrosyl phosphatase.

1988 • 51 citations

A Novel Putative Protein-tyrosine Phosphatase Contains a BRO1-like Domain and Suppresses Ha-ras-mediated Transformation

1998 • 48 citations

Suppression of v-fms-induced transformation by overexpression of a truncated T-cell protein tyrosine phosphatase.

1993 • 48 citations

Rat acid phosphatase: overexpression of active, secreted enzyme by recombinant baculovirus-infected insect cells, molecular properties, and crystallization.

1993 • 47 citations

Negative growth control by a novel lowM_rphosphotyrosine protein phosphatase in normal and transformed cells

1993 • 46 citations

Association of the protein tyrosine phosphatase PTP1C with the protein tyrosine kinase c‐Src in human platelets

1996 • 38 citations

Structural Origins of l(+)-Tartrate Inhibition of Human Prostatic Acid Phosphatase

1998 • 38 citations

Cloning and Analysis of the Promoter Activity of the Human Prostatic Acid Phosphatase Gene

1998 • 38 citations

The expression of prostatic acid phosphatase is transcriptionally regulated in human prostate carcinoma cells

1995 • 38 citations

The cellular level of prostatic acid phosphatase and the growth of human prostate carcinoma cells

1994 • 32 citations

Protein tyrosine phosphatases: their roles in signal transduction.

1996 • 29 citations

Tyrosine Phosphorylation of a 185 kDa Phosphoprotein (pp185) Inversely Correlates with the Cellular Activity of Human Prostatic Acid Phosphatase

1996 • 26 citations

PSA and acid phosphatase in the diagnosis of prostate cancer

1998 • 25 citations

LAR‐PTPase cDNA transfection suppression of tumor growth of neu oncogene‐transformed human breast carcinoma cells

1995 • 21 citations

Cationic Liposome-Mediated Incorporation of Prostatic Acid Phosphatase Protein into Human Prostate Carcinoma Cells

1993 • 20 citations

Carbohydrate removal fails to eliminate the heterogeneity of human prostatic acid phosphatase

1989 • 14 citations

Oncogenes and proto-oncogenes

1986 • 14 citations