Pre-eclampsia, the Placenta and the Maternal Systemic Inflammatory Response—A Review

Atherosclerosis

2000 • 4,558 citations

Preeclampsia: An excessive maternal inflammatory response to pregnancy

1999 • 1,855 citations

Preeclampsia: An endothelial cell disorder

1989 • 1,848 citations

Genetic Conflicts in Human Pregnancy

1993 • 1,234 citations

Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome)

1993 • 1,078 citations

Reactive oxygen species, cell signaling, and cell injury

2000 • 1,005 citations

A study of placental bed spiral arteries and trophoblast invasion in normal and severe pre‐eclamptic pregnancies

1994 • 901 citations

Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis

1998 • 821 citations

Is NF-kappaB the sensor of oxidative stress?

1999 • 786 citations

TNF-α Is a Predictor of Insulin Resistance in Human Pregnancy

2002 • 689 citations

Is NF‐κB the sensor of oxidative stress?

1999 • 669 citations

Placental bed spiral arteries in the hypertensive disorders of pregnancy

1991 • 665 citations

Pre-eclampsia and the placenta

1991 • 592 citations

Heterogeneous causes constituting the single syndrome of preeclampsia: A hypothesis and its implications

1996 • 574 citations

Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation

2002 • 510 citations

Placental Debris, Oxidative Stress and Pre-eclampsia

2000 • 498 citations

Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre‐eclamptic pregnancies

1998 • 492 citations

Quantitative Abnormalities of Fetal DNA in Maternal Serum in Preeclampsia

1999 • 483 citations

Fetal and maternal contributions to risk of pre-eclampsia: population based study

1998 • 461 citations

Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes.

1997 • 405 citations

Villous cytotrophoblast regulation of the syncytial apoptotic cascade in the human placenta

1998 • 399 citations

Circulating Levels of Immunoreactive Cytokines in Women with Preeclampsia

1998 • 399 citations

Interleukin‐6, turnour necrosis factor and soluble turnour necrosis factor receptors in women with pre‐eclampsia

1995 • 389 citations

Expression of Inflammatory Cytokines in Placentas from Women with Preeclampsia¹

2001 • 326 citations

Gestational Age-Dependent Expression of IL-10 and Its Receptor in Human Placental Tissues and Isolated Cytotrophoblasts

2000 • 315 citations

Elevation of both maternal and fetal extracellular circulating deoxyribonucleic acid concentrations in the plasma of pregnant women with preeclampsia

2001 • 283 citations

The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection.

1997 • 273 citations

Increased concentrations of cytokines interleukin-6 and interleukin-1 receptor antagonist in plasma of women with preeclampsia: a mechanism for endothelial dysfunction?

1994 • 269 citations

Inflammation, sepsis, and coagulation.

1999 • 248 citations

The Kidney in Toxemia of Pregnancy

1960 • 238 citations

Expression of Inflammatory Cytokines in Placentas from Women with Preeclampsia

2001 • 237 citations

Uterine Artery Doppler Flow and Uteroplacental Vascular Pathology in Normal Pregnancies and Pregnancies Complicated by Pre-eclampsia and Small for Gestational Age Fetuses

2001 • 236 citations

An ultrastructural and ultrahistochemical study of the human placenta in maternal pre-eclampsia

1980 • 234 citations

Circulating markers of oxidative stress are raised in normal pregnancy and pre‐eclampsia

1998 • 233 citations

The effect of placental syncytiotrophoblast microvillous membranes from normal and pre‐eclamptic women on the growth of endothelial cells in vitro

1993 • 232 citations

Trophoblast Deportation in Human Pregnancy—its Relevance for Pre-eclampsia

1999 • 230 citations

Apoptosis in human cultured trophoblasts is enhanced by hypoxia and diminished by epidermal growth factor

2000 • 211 citations

ON THE PATHOGENESIS OF PLACENTAL INFARCTS IN PRE‐ECLAMPSIA

1972 • 210 citations

Changing Paternity and the Risk of Preeclampsia/Eclampsia in the Subsequent Pregnancy

2000 • 203 citations

Apoptotic changes occur in syncytiotrophoblast of human placental villi where fibrin type fibrinoid is deposited at discontinuities in the villous trophoblast

1996 • 196 citations

TAFI antigen and D‐dimer levels during normal pregnancy and at delivery

2001 • 170 citations

Activation of Leukocytes During the Uteroplacental Passage in Preeclampsia

2002 • 164 citations

Proliferation, Differentiation and Apoptosis in Villous Trophoblast at 13–41 Weeks of Gestation (Including Observations on Annulate Lamellae and Nuclear Pore Complexes)

1999 • 163 citations

Recognition of Trophoblast HLA Class I Molecules by Decidual NK Cell Receptors—A Review

2000 • 159 citations

Extensive platelet activation in preeclampsia compared with normal pregnancy: Enhanced expression of cell adhesion molecules

1997 • 150 citations

Ultrastructural aspects of preeclampsia

1989 • 136 citations

Down regulation of peroxisome proliferator-activated receptorγ expression by inflammatory cytokines and its reversal by thiazolidinediones

1999 • 126 citations

INTERVILLOUS BLOOD FLOW IN NORMAL AND COMPLICATED LATE PREGNANCY MEASURED BY MEANS OF AN INTRAVENOUS ¹³³XE METHOD

1980 • 119 citations

Maternal Second Trimester Serum Tumor Necrosis Factor- -soluble Receptor p55 (sTNFp55) and Subsequent Risk of Preeclampsia

1999 • 117 citations

Prospective Evaluation of Hemostatic System Activation and Thrombin Potential in Healthy Pregnant Women with and without Factor V Leiden

1999 • 114 citations

Dyslipidemia, Iron, and Oxidative Stress in Preeclampsia: Assessment of Maternal and Feto-Placental Interactions

1998 • 109 citations

Flow Cytometric Detection of Circulating Activated Platelets and Platelet Hyper-Responsiveness in Pre-Eclampsia and Pregnancy

1994 • 105 citations

Clinical correlations of patterns of placental pathology in preterm pre-eclampsia

1998 • 101 citations

Levels of dimethylarginines and cytokines in mild and severe preeclampsia

2001 • 100 citations

Maternal uterine vascular lesions in the hypertensive complications of pregnancy.

1976 • 85 citations

Lipid peroxide and vitamin E patterns in pregnant women with different types of hypertension in pregnancy

1998 • 77 citations

Pre-eclampsia is associated with an increase in trophoblast glycogen content and glycogen synthase activity, similar to that found in hydatidiform moles.

1993 • 76 citations

Enhanced Protein Levels of Protein Thiol/Disulphide Oxidoreductases in Placentae from Pre-eclamptic subjects

2001 • 63 citations

Assessment of uterine arterial notching as a screening test for adverse pregnancy outcome

1998 • 62 citations

Elevated soluble adhesion molecules in women with pre-eclampsia

1999 • 61 citations

Pregnancy induced hypertension: a role for peroxidation in microvillus plasma membranes

1994 • 60 citations

Levels of dimethylarginines and cytokines in mild and severe preeclampsia

2001 • 60 citations

Tumor Markers in Hypertensive Disorders of Pregnancy

1993 • 51 citations

Abnormal placentation.

1985 • 51 citations

Complement activation and anaphylatoxin (C3a and C5a) formation in preeclampsia and by amniotic fluid.

1989 • 43 citations

The Human Placenta

1993 • 40 citations

Classical complement activation induced by pregnancy: implications for management of connective tissue diseases.

1992 • 35 citations

The Kidney in Toxemia of Pregnancy

1966 • 27 citations

Mechanisms Involved in the Induction of Human Endothelial Cell Necrosis

1996 • 26 citations

Recent Work on the Etiology of Eclampsia.

1909 • 14 citations

Two choice human embryos at Streeter's horizons XI and XIV.

1959 • 7 citations

Deleted Work

1955 • 0 citations