Hypoxia and anemia: effects on tumor biology and treatment resistance

Targeting HIF-1 for cancer therapy

2003 • 6,321 citations

Hypoxia — a key regulatory factor in tumour growth

2002 • 4,942 citations

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1989 • 3,308 citations

Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects

2001 • 2,558 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.

1996 • 1,747 citations

The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.

1998 • 1,506 citations

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

2003 • 1,276 citations

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1996 • 1,195 citations

HIF-1 and tumor progression: pathophysiology and therapeutics

2002 • 1,025 citations

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

2001 • 917 citations

Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition

1999 • 663 citations

Regulation of Protein Synthesis by Hypoxia via Activation of the Endoplasmic Reticulum Kinase PERK and Phosphorylation of the Translation Initiation Factor eIF2α

2002 • 658 citations

Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1.

2003 • 617 citations

Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL

1995 • 611 citations

Treatment Resistance of Solid Tumors

2001 • 533 citations

Tumor Hypoxia and Malignant Progression

2004 • 464 citations

Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues.

1994 • 449 citations

Transcriptional Response to Hypoxia in Human Tumors

2001 • 300 citations

Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors.

2001 • 294 citations

Tyrosine Phosphorylation of IκBα Activates NFκB through a Redox-regulated and c-Src-dependent Mechanism Following Hypoxia/Reoxygenation

2003 • 184 citations

The Genomic Response of Tumor Cells to Hypoxia and Reoxygenation

1995 • 178 citations

Hypoxic stress proteins: Survival of the fittest

1996 • 161 citations

Blood Perfusion and Microenvironment of Human Tumors

2000 • 127 citations

Impact of haemoglobin levels on the outcome of cancers treated with chemotherapy

2003 • 125 citations

Oxygen Regulation of Gene Expression: A Study in Opposites

2000 • 125 citations

A Pathway of Neuronal Apoptosis Induced by Hypoxia/Reoxygenation

2000 • 116 citations

The Response of c-Jun/AP-1 to Chronic Hypoxia Is Hypoxia-Inducible Factor 1α Dependent

2002 • 101 citations

A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology

2002 • 93 citations

Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells

2002 • 87 citations

Significance of Hemoglobin Concentration for Treatment Outcome

2000 • 54 citations

Regulation of cell proliferation under extreme and moderate hypoxia: the role of pyrimidine (deoxy)nucleotides

1994 • 45 citations

Molecular analysis of selected cell cycle regulatory proteins during aerobic and hypoxic maintenance of human ovarian carcinoma cells

1999 • 42 citations

European School of Oncology

2001 • 20 citations