Significance of Hemoglobin Concentration for Treatment Outcome

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

1955 • 2,174 citations

The Concentration of Oxygen Dissolved in Tissues at the Time of Irradiation as a Factor in Radiotherapy

1953 • 2,102 citations

Hemoglobin: Molecular, Genetic and Clinical Aspects.

1986 • 1,005 citations

Decreased Erythropoietin Response in Patients with the Anemia of Cancer

1990 • 680 citations

Influence of Cigarette Smoking on the Efficacy of Radiation Therapy in Head and Neck Cancer

1993 • 581 citations

Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation

1979 • 523 citations

Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers

1996 • 424 citations

Definitive evidence for hypoxic cells influencing cure in cancer therapy.

1978 • 422 citations

THE EFFECT OF CARBON MONOXIDE ON THE OXYHEMOGLOBIN DISSOCIATION CURVE

1944 • 298 citations

Primary radiotherapy of larynx and pharynx carcinoma—An analysis of some factors influencing local control and survival

1986 • 241 citations

The significance of anemia in clinical radiation therapy

1986 • 222 citations

Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of larynx and pharynx: Report from the DAHANCA 2 study

1989 • 216 citations

The Effect of Cigarette Smoking on Hemoglobin Levels and Anemia Screening

1990 • 209 citations

Prognostic factors of nasopharyngeal carcinoma: a review of 759 patients

1990 • 206 citations

Radical Radiotherapy for Muscle Invasive Transitional Cell Carcinoma of the Bladder: Failure Analysis

1989 • 200 citations

Pretreatment hemoglobin level influences local control and survival of T1-T2 squamous cell carcinomas of the glottic larynx.

1995 • 196 citations

Prognostic value of hemoglobin concentrations and blood transfusions in advanced carcinoma of the cervix treated by radiation therapy: Results of a retrospective study of 386 patients

1989 • 169 citations

Clinical radiobiology of squamous cell carcinoma of the oropharynx

1991 • 167 citations

Sensitization of Hypoxic Tumour Cells—Clinical Experience

1989 • 156 citations

Pretreatment prognostic factors in carcinoma of the uterine cervix: A multivariable analysis of the effect of age, stage, histology and blood counts on survival

1983 • 151 citations

The Influence of Anemia on the Results of Radiotherapy in Carcinoma of the Cervix

1965 • 137 citations

Intercapillary distance measurement as an indicator of hypoxia in carcinoma of the cervix uteri

1986 • 130 citations

Erythropoietin increases hemoglobin during radiation therapy for cervical cancer

1994 • 126 citations

Erythropoietin increases hemoglobin in cancer patients during radiation therapy

1993 • 126 citations

Radiotherapy and anaemia — the clinical experience

1991 • 110 citations

The effect of fraction size on control of early glottic cancer

1988 • 106 citations

BEZAFIBRATE LOWERS OXYGEN AFFINITY OF HAEMOGLOBIN

1983 • 102 citations

Prognostic and treatment factors affecting pelvic control of stage ib and iia-b carcinoma of the intact uterine cervix treated with radiation therapy alone

1984 • 101 citations

Primary radical radiotherapy for T3 transitional cell cancer of the bladder: an analysis of survival and control

1986 • 101 citations

The prognostic value of hemoglobin and a decrease in hemoglobin during radiotherapy in laryngeal carcinoma

1992 • 100 citations

Nimorazole as a hypoxic radiosensitizer in the treatment of supraglottic larynx and pharynx carcinoma. First report from the Danish Head and Neck Cancer Study (DAHANCA) protocol 5-85

1991 • 94 citations

Anemia: A problem or an opportunity in radiotherapy?

1986 • 94 citations

Prognostic factors in patients with bladder carcinoma treated with definitive irradiation

1990 • 82 citations

Physiological and x-ray studies of potential antisickling agents.

1983 • 80 citations

Prognostic assessment of tumor regression after external irradiation for cervical cancer

1992 • 80 citations

Local control of muscle-invasive bladder cancer: Preoperative radiotherapy and cystectomy versus cystectomy alone

1995 • 80 citations

Relationship between radiobiological hypoxia and direct estimates of tumour oxygenation in a mouse tumour model

1993 • 76 citations

Prognostic factors for local and distant recurrence in Stage I and II cervical carcinoma

1995 • 72 citations

Utilization of oxygen by transplanted tumors in vivo.

1967 • 69 citations

Proliferation measurements with flow cytometry Tpot in cancer of the uterine cervix: Correlation between two laboratories and preliminary clinical results

1995 • 68 citations

Association of Hemoglobin Levels Before and During Radiotherapy with Prognosis in Uterine Cervix Cancer

1973 • 68 citations

Misonidazole combined with radiotherapy in the treatment of carcinoma of the uterine cervix

1989 • 61 citations

Radiation myelitis and survival in the radiotherapy of lung cancer

1988 • 56 citations

Effect of Short-Term Smoking Halt on Carboxyhemoglobin Levels and P50 Values

1987 • 55 citations

Effect of Short-term Smoking Halt on Carboxyhemoglobin Levels and P50 Values

1986 • 55 citations

Prognostic indices for bladder cancer: An analysis of patients with transitional cell carcinoma of the bladder primarily treated by radical megavoltage X-ray therapy

1986 • 55 citations

Carcinoma of the nasopharynx: Analysis of treatment results in 167 consecutively admitted patients

1992 • 55 citations

Tumor Oxygenation in Anemic Rats: Effects of Erythropoietin Treatment Versus Red Blood Cell Transfusion

1995 • 54 citations

Prognostic Value of Pretreatment Factors in Patients with Locally Advanced Carcinoma of the Uterine Cervix Treated by Radiotherapy Alone

1995 • 54 citations

Preoperative radiotherapy for muscle-invasive bladder carcinoma. Long term follow-up and prognostic factors for 338 patients

1994 • 53 citations

Effect of subcutaneous recombinant human erythropoietin in cancer patients receiving radiotherapy: Preliminary results of a randomized, open-labeled, phase II trial

1993 • 53 citations

Hemoglobin, radiation, morbidity and survival

1986 • 52 citations

Smoking: The influence of carboxyhemoglobin (HbCO) on tumor oxygenation and response to radiation

1978 • 52 citations

Induction of hypoxia in normal and malignant tissues by changing the oxygen affinity of hemoglobin—Implications for theraphy

1986 • 48 citations

Influence of carboxyhemoglobin level on tumor growth, blood flow, and radiation response in an experimental model

1992 • 43 citations

Tumor radiosensitization through reductions in hemoglobin affinity

1986 • 43 citations

The influence of hemoglobin level on the regression and long term local control of transitional cell carcinoma of the bladder following photon irradiation

1986 • 41 citations

The influence of initial hemoglobin and blood pressure levels on results of radiation therapy for carcinoma of the prostate

1989 • 41 citations

The Modification of Hemoglobin Affinity for Oxygen and Tumor Radiosensitivity by Antilipidemic Drugs

1987 • 41 citations

Effect of carboxyhemoglobin on tumor oxygen unloading capacity in patients with squamous cell carcinoma of the head and neck

1992 • 36 citations

Squamous Cell Carcinoma of the Oropharynx

1990 • 36 citations

The Adaptive Response of Mouse Tumours to Anaemia and Retransfusion

1987 • 34 citations

Blood pressure and hemoglobin concentration: Multivariate analysis of local control after irradiation for head and neck cancer

1984 • 32 citations

Effect of carbon monoxide breathing on hypoxia and radiation response in the SCCVII tumor in vivo

1994 • 31 citations

Blood tests and prognosis in bladder carcinomas treated with definitive radiotherapy

1993 • 30 citations

Survival, prognostic factors, and relapse patterns in uterine cervical carcinoma

1983 • 30 citations

The relationship between carbon monoxide breathing, tumour oxygenation and local tumour control in the C3H mammary carcinoma in vivo

1994 • 29 citations

The influence of haemoglobin affinity for oxygen on tumour radiosensitivity

1987 • 28 citations

The Oxygen Effect in Radiotherapy � Historical Review

2015 • 27 citations

On the effect of an æmia on the reactions of the skin and of tumours to radium exposure

1932 • 26 citations

Factors Affecting Survival in Over 500 Patients with Stage II Carcinoma of the Cervix

1977 • 25 citations

Changes in tumour morphology with alterations in oxygen availability: further evidence for oxygen as a limiting substrate

1991 • 25 citations

The influence of haemoglobin concentration on the response to radiotherapy

1988 • 24 citations

Radiotherapy and TNM classification of cancer of the larynx. A study based on 1447 cases seen at the Radiotherapy Clinic of Helsinki during 1936-1961.

1968 • 24 citations

The role of hemoglobin concentration in the outcome of misonidazole-sensitized radiotherapy of head and neck cancers: Based on rtog trial #79-15

1989 • 23 citations

The effect of recombinant human erythropoietin treatment on tumour radiosensitivity and cancer-associated anaemia in the mouse

1993 • 23 citations

Chlorophenoxy acetic acid derivatives as hemoglobin modifiers and tumor radiosensitizers

1989 • 23 citations

DNA Analysis in Predicting Survival of Irradiated Patients with Transitional Cell Carcinoma of Bladder

1992 • 21 citations

Long term follow-up results of high-dose rate remote afterloading intracavitary radiation therapy for carcinoma of the uterine cervix.

1994 • 21 citations

What is the importance of anaemia in radiotherapy? The value of animal studies

1991 • 19 citations

Induction of severe tumor hypoxia by modifiers of the oxygen affinity of hemoglobin

1989 • 17 citations

BW12C: effects on tumour hypoxia, tumour thermosensitivity and relative tumour and normal tissue perfusion in C3H mice

1991 • 17 citations

Effects of the manipulation of oxyhemoglobin status by BW121 on tumor thermosensitivity and on blood flow in tumor and normal tissues in mice

1989 • 16 citations

The treatment of tumors by the induction of anemia and irradiation in hyperbaric oxygen

1989 • 16 citations

Could manipulation of the binding affinity of haemoglobin for oxygen be used clinically to sensitize tumours to radiation?

1991 • 15 citations

The effect of arterial oxygen content on the results of radiation therapy for epidermoid bronchogenic carcinoma

1989 • 15 citations

Anaemia as a Prognostic Factor for the Therapeutic Effect of Radiosensitizers

1987 • 13 citations

Radiation therapy in the treatment of cervical Cancer: The university of Chicago/Michael reese hospital experience

1990 • 13 citations

Head and Neck Cancer, vol 1,

1986 • 13 citations

Results of treatment and lessons learned from pathologically staged T4 non‐small cell lung cancer

1991 • 12 citations

Analysis of the effect of bezafibrate on the oxygen dissociation curve of human hemoglobin

1984 • 11 citations

Influence of Boost Technique (External Beam Radiotherapy or Brachytherapy) on the Outcome of Patients with Carcinoma of the Base of the Tongue

1995 • 11 citations

In situ tumour radio sensitization induced by clofibrate administration: single dose and fractionated studies

1991 • 9 citations

Stage I glottic carcinoma: An analysis of tumour recurrence after primary radiotherapy

1990 • 9 citations

Does Initial Haemoglobin Level Modify the Efficacy of Radiosensitizers? An Analysis of the MRC Misonidazole Studies in Head and Neck Cancer and Cervix Cancer

1987 • 9 citations

Results of postoperative radiotherapy for clinical stage Ib uterine cervical carcinoma with evidence of microscopic involvement of surgical margin, parametrium and/or lymph node metastasis.

1991 • 8 citations

Prognostic Importance of Anemia Related Parameters in Patients with Carcinoma of the Cervix Uteri

1990 • 7 citations

BW12C-induced changes in haemoglobin-oxygen affinity in mice and its influence on the radiation response of a C3H mouse mammary carcinoma

1992 • 6 citations

Fever, haemoglobin and smoking as prognostic factors during the treatment of cervical carcinoma by radiotherapy.

1990 • 6 citations

Lung function and radiation response

1991 • 4 citations