A dual-Ca2+-sensor model for neurotransmitter release in a central synapse

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse

1994 • 1,485 citations

Synaptotagmin I functions as a calcium regulator of release probability

2001 • 964 citations

Intracellular calcium dependence of transmitter release rates at a fast central synapse

2000 • 773 citations

Calcium dependence of the rate of exocytosis in a synaptic terminal

1994 • 746 citations

Calcium influx and transmitter release in a fast CNS synapse

1996 • 633 citations

Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron–principal neuron synapse

2005 • 572 citations

Two components of transmitter release at a central synapse.

1994 • 528 citations

Calcium Sensitivity of Glutamate Release in a Calyx-Type Terminal

2000 • 511 citations

Calcium Channel Types with Distinct Presynaptic Localization Couple Differentially to Transmitter Release in Single Calyx-Type Synapses

1999 • 438 citations

Direct patch recording from identified presynaptic terminals mediating glutamatergic EPSCs in the rat CNS, in vitro.

1994 • 365 citations

Presynaptic calcium and control of vesicle fusion

2005 • 337 citations

Synaptotagmin-1, -2, and -9: Ca2+ Sensors for Fast Release that Specify Distinct Presynaptic Properties in Subsets of Neurons

2007 • 325 citations

Identification of Candidate Gene Variants in Korean MODY Families by Whole-Exome Sequencing

2015 • 319 citations

Activity-Dependent Modulation of the Rate at which Synaptic Vesicles Become Available to Undergo Exocytosis

1998 • 317 citations

Allosteric modulation of the presynaptic Ca2+ sensor for vesicle fusion

2005 • 293 citations

Modulation of Transmitter Release by Presynaptic Resting Potential and Background Calcium Levels

2005 • 272 citations

The Coupling between Synaptic Vesicles and Ca2+ Channels Determines Fast Neurotransmitter Release

2007 • 256 citations

Delayed Release of Neurotransmitter from Cerebellar Granule Cells

1998 • 254 citations

Endocannabinoid-Mediated Long-Term Plasticity Requires cAMP/PKA Signaling and RIM1α

2007 • 250 citations

Autonomous Function of Synaptotagmin 1 in Triggering Synchronous Release Independent of Asynchronous Release

2005 • 242 citations

Inhibitory Transmission Mediated by Asynchronous Transmitter Release

2000 • 235 citations

Fast Kinetics of Exocytosis Revealed by Simultaneous Measurements of Presynaptic Capacitance and Postsynaptic Currents at a Central Synapse

2001 • 234 citations

The calyx of Held

2006 • 221 citations

Quantitative Relationship between Transmitter Release and Calcium Current at the Calyx of Held Synapse

2001 • 215 citations

Synaptotagmin-2 Is Essential for Survival and Contributes to Ca²⁺Triggering of Neurotransmitter Release in Central and Neuromuscular Synapses

2006 • 214 citations

Purification of the N-type calcium channel associated with syntaxin and synaptotagmin. A complex implicated in synaptic vesicle exocytosis.

1994 • 210 citations

Developmental changes in calcium channel types mediating synaptic transmission in rat auditory brainstem

1998 • 208 citations

Local routes revisited: the space and time dependence of the Ca2+ signal for phasic transmitter release at the rat calyx of Held

2003 • 185 citations

Properties of Synchronous and Asynchronous Release During Pulse Train Depression in Cultured Hippocampal Neurons

2001 • 175 citations

Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release

2006 • 170 citations

Reciprocal regulation of P/Q-type Ca2+ channels by SNAP-25, syntaxin and synaptotagmin

1999 • 168 citations

Competition between Phasic and Asynchronous Release for Recovered Synaptic Vesicles at Developing Hippocampal Autaptic Synapses

2004 • 167 citations

Physiological Temperatures Reduce the Rate of Vesicle Pool Depletion and Short-Term Depression via an Acceleration of Vesicle Recruitment

2006 • 156 citations

The Synaptotagmin C2A Domain Is Part of the Calcium Sensor Controlling Fast Synaptic Transmission

2003 • 149 citations

Control of synaptic strength and timing by the release-site Ca2+ signal

2005 • 127 citations

Different Effects on Fast Exocytosis Induced by Synaptotagmin 1 and 2 Isoforms and Abundance But Not by Phosphorylation

2006 • 125 citations

A Mechanism Intrinsic to the Vesicle Fusion Machinery Determines Fast and Slow Transmitter Release at a Large CNS Synapse

2007 • 125 citations

Heterogeneous Presynaptic Release Probabilities: Functional Relevance for Short-Term Plasticity

2003 • 123 citations

Release kinetics, quantal parameters and their modulation during short‐term depression at a developing synapse in the rat CNS

2005 • 119 citations

Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha 1A subunit of the P/Q-type calcium channel

1997 • 116 citations

Action potentials must admit calcium to evoke transmitter release

1991 • 115 citations

Simultaneous Measurement of Intracellular Ca²⁺ and Asynchronous Transmitter Release from the same Crayfish Bouton

1997 • 81 citations

Synapsins regulate use-dependent synaptic plasticity in the calyx of Held by a Ca ²⁺ /calmodulin-dependent pathway

2006 • 78 citations

Role of Ca²⁺ in the Synchronization of Transmitter Release at Calyceal Synapses in the Auditory System of Rat

2002 • 21 citations