Epidermal growth factor and transforming growth factor alpha specifically induce the activation- and hyperproliferation-associated keratins 6 and 16.

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells

1982 • 5,272 citations

PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERS

1991 • 1,078 citations

[36] Eukaryotic gene transcription with purified components

1983 • 992 citations

Production and auto-induction of transforming growth factor-α in human keratinocytes

1987 • 870 citations

Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-α and epidermal growth factor

1987 • 703 citations

Epidermal differentiation: the bare essentials.

1990 • 651 citations

Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: Genetic and functional analyses

1991 • 647 citations

Overexpression of Transforming Growth Factor α in Psoriatic Epidermis

1989 • 537 citations

Epidermolysis Bullosa Simplex: Evidence in Two Families for Keratin Gene Abnormalities

1991 • 426 citations

Occupation of the c-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor induction

1989 • 346 citations

c-fos Sequence Necessary for Basal Expression and Induction by Epidermal Growth Factor, 12-O-Tetradecanoyl Phorbol-13-Acetate and the Calcium Ionophore

1987 • 304 citations

The 5′ flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein.

1989 • 260 citations

Detection of transforming growth factor alpha in normal, malignant, and hyperproliferative human keratinocytes.

1988 • 227 citations

Expression and functional properties of transforming growth factor alpha and epidermal growth factor during mouse mammary gland ductal morphogenesis.

1991 • 196 citations

Basal cell-specific and hyperproliferation-related keratins in human breast cancer.

1991 • 185 citations

Modulation of keratinocyte motility. Correlation with production of extracellular matrix molecules in response to growth promoting and antiproliferative factors.

1988 • 164 citations

Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene.

1988 • 141 citations

Stimulation of casein kinase II by epidermal growth factor: relationship between the physiological activity of the kinase and the phosphorylation state of its beta subunit.

1990 • 129 citations

TGF-beta and retinoic acid: regulators of growth and modifiers of differentiation in human epidermal cells.

1990 • 129 citations

Transient synthesis of K6 and K16 keratins in regenerating rabbit corneal epithelium: keratin markers for an alternative pathway of keratinocyte differentiation

1989 • 126 citations

Mapping of epidermal growth factor-, serum-, and phorbol ester-responsive sequence elements in the c-jun promoter.

1992 • 101 citations

Expression of transfected transforming growth factor alpha induces a motile fibroblast-like phenotype with extracellular matrix-degrading potential in a rat bladder carcinoma cell line.

1990 • 95 citations

A GC-rich element confers epidermal growth factor responsiveness to transcription from the gastrin promoter.

1991 • 85 citations

Phenotypic transformation of normal rat kidney cells in a growth‐factor‐defined medium: Induction by a neuroblastoma‐derived transforming growth factor independently of the EGF receptor

1985 • 81 citations

Altered regulation of intercellular communication by epidermal growth factor, transforming growth factor-β and peptide hormones in normal human keratinocytes

1989 • 80 citations

Production of TGF-α and TGF-β by cultured keratinocytes, skin and oral squamous cell carcinomas – potential autocrine regulation of normal and malignant epithelial cell proliferation

1989 • 80 citations

Transphosphorylation as a possible mechanism for insulin and epidermal growth factor receptor activation.

1990 • 80 citations

Evolution of keratin genes: Different protein domains evolve by different pathways

1987 • 67 citations

Epithelial-specific keratin gene expression: identification of a 300 base-pair controlling segment

1990 • 41 citations

Functional Comparison of the Upstream Regulatory DNA Sequences of Four Human Epidermal Keratin Genes

1991 • 37 citations

Epidermal Growth Factor Activates Phosphoinositide Turnover and Protein Kinase C in BALB/MK Keratinocytes

1988 • 36 citations

Three parallel linkage groups of human acidic keratin genes

1990 • 23 citations

The calcium signal for BALB/MK keratinocyte terminal differentiation counteracts epidermal growth factor (EGF) very early in the EGF-induced proliferative pathway.

1988 • 22 citations

Mapping of Epidermal Growth Factor-, Serum-, and Phorbol Ester-Responsive Sequence Elements in the c-jun Promoter

1992 • 21 citations

A GC-Rich Element Confers Epidermal Growth Factor Responsiveness to Transcription from the Gastrin Promoter

1991 • 19 citations

The Calcium Signal for BALB/MK Keratinocyte Terminal Differentiation Counteracts Epidermal Growth Factor (EGF) Very Early in the EGF-Induced Proliferative Pathway

1988 • 8 citations