P16-Immunostaining Pattern as a Predictive Marker of Lymph Node Metastasis and Recurrence in Early Uterine Cervical Cancer

Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer

2003 • 6,072 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

Epidemiologic Evidence Showing That Human Papillomavirus Infection Causes Most Cervical Intraepithelial Neoplasia

1993 • 1,236 citations

The p16INK4a/CDKN2A tumor suppressor and its relatives

1998 • 917 citations

Human papillomavirus and cancer: the epidemiological evidence

2000 • 610 citations

p16(MTS-1/CDKN2/INK4a) in Cancer Progression

2001 • 470 citations

A prospective surgical pathological study of stage I squamous carcinoma of the cervix: A Gynecologic Oncology Group study

1989 • 372 citations

In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis

1999 • 321 citations

Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix.

2001 • 261 citations

Induced Expression of p16^INK4a Inhibits Both CDK4- and CDK2-Associated Kinase Activity by Reassortment of Cyclin-CDK-Inhibitor Complexes

1999 • 226 citations

p16INK4A as a marker for cervical dyskaryosis: CIN and cGIN in cervical biopsies and ThinPrepTM smears

2002 • 205 citations

Identification of prognostic factors and risk groups in patients found to have nodal metastasis at the time of radical hysterectomy for early-stage squamous carcinoma of the cervix

1989 • 194 citations

Analysis of factors contributing to treatment failures in Stages IB and IIA carcinoma of the cervix

1980 • 192 citations

Evaluation of p16INK4a and pRb expression in cervical squamous and glandular neoplasia

2004 • 175 citations

RADICAL PELVIC SURGERY VERSUS RADIATION THERAPY FOR STAGE I CARCINOMA OF THE CERVIX (EXCLUSIVE OF MICROINVASION)

1977 • 171 citations

Overexpression of p16 and p14ARF is associated with human papillomavirus infection in cervical squamous cell carcinoma and dysplasia

2002 • 107 citations

Prognostic significance of the depth of invasion relating to nodal metastases, parametrial extension, and cell types: A study of 628 cases with stage IB, IIA, and IIB cervical carcinoma

1984 • 104 citations

Identification of histopathologic risk groups in stage IB squamous cell carcinoma of the cervix.

1985 • 98 citations

Alteration of p16 and p15 genes in human uterine tumours

1999 • 97 citations

Expression of p27, p21, and p16 protein in early squamous cervical cancer and its relation to prognosis

2003 • 83 citations

Activation of cyclin D1-kinase in murine fibroblasts lacking both p21Cip1 and p27Kip1

2002 • 73 citations

Correlation between p14ARF/p16INK4A expression and HPV infection in uterine cervical cancer

2004 • 47 citations

p16 (CDKN2/cyclin-dependent kinase-4 inhibitor/multiple tumor suppressor-1) gene is not altered in uterine cervical carcinomas or cell lines.

1996 • 35 citations

Carcinoma of the Cervix: Clinicopathologic Correlation of 196 Cases

1976 • 34 citations

The prognostic impact of cyclin dependent kinase inhibitors p21^WAF1, p27^Kip1, and p16^INK4/MTS1 in adenocarcinomas of the uterine cervix

2003 • 27 citations

The prognostic significance of tumor emboli in lymphatic or vascular spaces of the cervical stroma in Stage IB squamous cell carcinoma of the cervix

1984 • 19 citations

Down-regulated p16 expression predicts poor prognosis in patients with extrahepatic biliary tract carcinomas

2002 • 13 citations