Mechanistic and phenomenological features of proton pumps in the respiratory chain of mitochondria

CHEMIOSMOTIC COUPLING IN OXIDATIVE AND PHOTOSYNTHETIC PHOSPHORYLATION

1966 • 3,631 citations

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

1990 • 2,969 citations

Possible molecular mechanisms of the protonmotive function of cytochrome systems

1976 • 1,252 citations

Oxygen activation and the conservation of energy in cell respiration

1992 • 1,121 citations

Oxidases and Related Redox Systems

1982 • 818 citations

Oxidative Phosphorylation and Photophosphorylation

1977 • 737 citations

Proton pump coupled to cytochrome c oxidase in mitochondria

1977 • 720 citations

The Influence of Respiration and ATP Hydrolysis on the Proton‐Electrochemical Gradient across the Inner Membrane of Rat‐Liver Mitochondria as Determined by Ion Distribution

1974 • 707 citations

The respiratory‐chain NADH dehydrogenase (complex I) of mitochondria

1991 • 489 citations

Cytochrome oxidase : a synthesis

1981 • 334 citations

Structure and function of energy-transducing membranes

1978 • 334 citations

Differential effects of antimycin on ubisemiquinone bound in different environments in isolated succinate . cytochrome c reductase complex.

1980 • 289 citations

Proton-pumping cytochrome c oxidase

1979 • 280 citations

Identification of the electron transfers in cytochrome oxidase that are coupled to proton-pumping

1989 • 272 citations

Oxidases and Related Redox Systems

1989 • 252 citations

Insight into the active-site structure and function of cytochrome oxidase by analysis of site-directed mutants of bacterial cytochromeaa 3 and cytochromebo

1993 • 250 citations

Proton translocation reactions in the respiratory chains

1976 • 248 citations

Redox potentiometry in mitochondrial and photosynthetic bionergetics

1974 • 242 citations

Cytochrome c oxidase: understanding nature's design of a proton pump

1990 • 189 citations

On the Redox Potentials of Ubiquinone and Cytochrome b in the Respiratory Chain

1969 • 182 citations

Heme-heme interaction in cytochrome oxidase

1972 • 174 citations

Regulation in macromolecules as illustrated by haemoglobin

1968 • 159 citations

Involvement of intramitochondrial protons in redox reactions of cytochrome a

1978 • 158 citations

Proton uptake by cytochrome c oxidase on reduction and on ligand binding

1994 • 150 citations

Slip and leak in mitochondrial oxidative phosphorylation

1989 • 150 citations

Cytochrome c oxidase as a redox-linked proton pump

1990 • 148 citations

Cytochrome oxidase as a redox-linked proton pump.

1992 • 147 citations

Energy Conservation in Biological Membranes

1978 • 147 citations

Resolution of the reaction sequence during the reduction of O2 by cytochrome oxidase.

1993 • 143 citations

Molecular slipping in redox and ATPase H+ pumps

1983 • 131 citations

Spectroelectrochemical study of cytochrome c oxidase: pH and temperature dependences of the cytochrome potentials. Characterization of site-site interactions.

1986 • 123 citations

Coordination dynamics of heme-copper oxidases. The ligand shuttle and the control and coupling of electron transfer and proton translocation

1993 • 123 citations

b-Type Cytochromes

1980 • 112 citations

Changes in permeability to protons and other cations at high proton motive force in rat liver mitochondria

1986 • 106 citations

Proton transfer during the reaction between fully reduced cytochrome c oxidase and dioxygen: pH and deuterium isotope effects

1992 • 92 citations

Coupling site I and the rotenone‐sensitive ubisemiquinone in tightly coupled submitochondrial particles

1990 • 88 citations

Chemiosmotic coupling in cytochrome oxidase

1985 • 86 citations

Haem—haem interactions in cytochrome aa3 during the anaerobic-aerobic transition

1974 • 85 citations

Spectroelectrochemical study of the cytochrome a site in carbon monoxide-inhibited cytochrome c oxidase

1986 • 83 citations

Expression of retinoic acid receptor genes in neural crest‐derived cells during mouse facial development

1990 • 82 citations

Protonmotive functions of cytochrome c oxidase in reconstituted vesicles. Influence of turnover rate on ‘proton translocation’

1983 • 73 citations

Redox-linked proton translocation in cytochrome oxidase: the importance of gating electron flow. The effects of slip in a model transducer

1986 • 72 citations

Hypothesis. Cytochrome c oxidase as a proton pump. A transition-state mechanism.

1985 • 71 citations

The cytochrome chain of mitochondria exhibits variable H⁺/e⁻ stoichiometry

1991 • 70 citations

The effect of pH on redox titrations of haem a in cyanide-liganded cytochrome-c oxidase: experimental and modelling studies

1990 • 68 citations

Uptake and release of protons during the reaction between cytochrome c oxidase and molecular oxygen: a flow-flash investigation

1991 • 67 citations

H₂O₂‐Induced Conversion of Cytochrome c Oxidase Peroxy Complex to Oxoferryl State

1988 • 64 citations

Highlights in ubiquinone research

1990 • 63 citations

Proton translocation in cytochromec oxidase: Redox linkage through proximal ligand exchange on cytochromea 3

1993 • 62 citations

The gateway to the active site of heme-copper oxidases

1993 • 61 citations

The H+/e− stoicheiometry of respiration-linked proton translocation in the cytochrome system of mitochondria

1980 • 61 citations

A new redox loop formality involving metal‐catalysed hydroxide‐ion translocation A hypothetical Cu loop mechanism for cytochrome oxidase

1987 • 61 citations

The oxidation‐reduction potential of the copper signal in pigeon heart mitochondria

1971 • 61 citations

H⁺/e⁻ stoichiometry of mitochondrial cytochrome complexes reconstituted in liposomes Rate‐dependent changes of the stoichiometry in the cytochrome c oxidase vesicles

1991 • 59 citations

Cytochrome c oxide as a proton pump. A transition-state mechanism

1985 • 58 citations

Proton translocation and energy transduction in mitochondria

1973 • 58 citations

Protonation states of the catalytic intermediates of cytochrome c oxidase

1992 • 56 citations

Proton translocation coupled to quinol oxidation in ox heart mitochondria

1973 • 54 citations

The stoichiometry of charge translocation by cytochrome oxidase and the cytochrome bc₁ complex of mitochondria at high membrane potential

1988 • 53 citations

Site-directed mutagenesis of highly conserved residues in helix VIII of subunit I of the cytochrome bo ubiquinol oxidase from Escherichia coli: An amphipathic transmembrane helix that may be important in conveying protons to the binuclear center

1993 • 52 citations

Alternative hypotheses of proton ejection in cytochrome oxidase vesicles

1983 • 50 citations

The mechanism of transmembrane ΔμH+ generation in mitochondria by cytochrome c oxidase

1979 • 50 citations

The Relative Proton Stoichiometries of the Mitochondrial Proton Pumps Are Independent of the Proton Motive Force

1989 • 50 citations

Keeping a light-driven proton pump under control

1984 • 49 citations

Redox bohr‐effects in the cytochrome system of mitochondria

1979 • 49 citations

Mechanism of respiration-driven proton translocation in the inner mitochondrial membrane. Analysis of proton translocation associated with oxidation of endogenous ubiquinol

1975 • 49 citations

The mechanism of proton translocation in respiration and photosynthesis

1989 • 45 citations

Flux ratios and pump stoichiometries at sites II and III in liver mitochondria. Effect of slips and leaks.

1991 • 43 citations

Effect of pH on the spectrum of cytochrome c oxidase hydrogen peroxide complex

1989 • 41 citations

Redox‐linked proton translocation in the b–c₁ complex from beef‐heart mitochondria reconstituted into phospholipid vesicles

1983 • 40 citations

Possible Protonmotive Osmochemistry in Cytochrome Oxidase

1988 • 37 citations

The osmochemistry of electron-transfer complexes

1991 • 37 citations

pH dependence of proton translocation by Escherichia coli.

1992 • 36 citations

[69] Measurement of →H+/O in mitochondria and submitochondrial vesicles

1979 • 36 citations

The H⁺/O stoicheiometry of mitochondrial respiration

1980 • 35 citations

Flash photolysis of the carbon monoxide compounds of wild-type and mutant variants of cytochrome bo from Escherichia coli

1994 • 34 citations

Characteristics of the redox‐linked proton ejection in beef‐heart cytochrome c oxidase reconstituted in liposomes

1987 • 34 citations

pH changes associated with cytochrome c oxidase reaction with H₂O₂ Protonation state of the peroxy and oxoferryl intermediates

1992 • 33 citations

Effect of papain digestion on polypeptide subunits and electron‐transfer pathways in mitochondrial b‐c₁ complex

1989 • 32 citations

Evidence for two H₂O₂‐binding sites in ferric cytochrome c oxidase Indication to the O‐cycle?

1987 • 30 citations

Protonmotive activity of cytochrome c oxidase: control of oxidoreduction of the heme centers by the protonmotive force in the reconstituted beef heart enzyme

1990 • 30 citations

Activation by reduction of the resting form of cytochrome c oxidase: Tests of different models and evidence for the involvement of CuB

1988 • 30 citations

Proton translocation by cytochrome oxidase in (antimycin + myxothiazol)-treated rat liver mitochondria using ferrocyanide or hexammineruthenium as electron donor

1986 • 28 citations

Characteristics of energy‐linked proton translocation in liposome reconstituted bovine cytochrome bc₁ complex

1992 • 26 citations

Intrinsic uncoupling in proton-pumping cytochrome c oxidase: pH dependence of cytochrome c oxidation in coupled and uncoupled phospholipid vesicles

1989 • 26 citations

Could CuB be the site of redox linkage in cytochrome c oxidase?

1992 • 25 citations

[31] Cooperative proton-transfer reactions in the respiratory chain: Redox Bohr effects

1986 • 25 citations

Heme a and a3 environments of plant cytochrome c oxidase

1990 • 24 citations

Mechanism of proton translocation associated to oxidation of N,N,N′,N′‐tetramethyl‐p‐phenylenediamine in rat liver mitochondria

1983 • 24 citations

Redox Bohr‐effects in isolated cytochrome bc₁ complex and cytochrome c oxidase from beef‐heart mitochondria

1981 • 20 citations

A Loop between Transmembrane Helixes IX and X of Subunit I of Cytochrome c Oxidase Caps the Heme a-Heme a3-CuB Center

1994 • 19 citations

Proton translocation by cytochrome oxidase vesicles catalyzing the peroxidatic oxidation of ferrocytochrome c.

1986 • 15 citations

Respiratory Chain Systems in Theory and Practice

1987 • 15 citations

Redox-Linked Proton Pumps in Mitochondria

1978 • 13 citations

[70] Determination of the H+/site and Ca2+/site ratios of mitochondrial electron transport

1979 • 11 citations