Nuclear β-Catenin Induces an Early Liver Progenitor Phenotype in Hepatocellular Carcinoma and Promotes Tumor Recurrence

Stem cells, cancer, and cancer stem cells

2001 • 9,488 citations

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

2008 • 8,256 citations

Liver Transplantation for the Treatment of Small Hepatocellular Carcinomas in Patients with Cirrhosis

1996 • 6,822 citations

Complex networks orchestrate epithelial–mesenchymal transitions

2006 • 3,818 citations

Cancer Stem Cells—Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem Cells

2006 • 2,961 citations

The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway

1999 • 2,206 citations

Hepatocellular carcinoma pathogenesis: from genes to environment

2006 • 1,940 citations

Wnt signalling and its impact on development and cancer

2008 • 1,518 citations

Migrating cancer stem cells — an integrated concept of malignant tumour progression

2005 • 1,323 citations

Diagnosis and Treatment of Hepatocellular Carcinoma

2008 • 1,109 citations

MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer

2004 • 842 citations

Wnt/β-catenin signaling in cancer stemness and malignant behavior

2007 • 757 citations

Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis

2003 • 679 citations

Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance☆

2004 • 612 citations

Mechanisms of Disease: mechanisms of hepatic fibrosis and therapeutic implications

2004 • 482 citations

Liver stem cells and their implication in hepatocellular and cholangiocarcinoma

2006 • 412 citations

The clinicopathological and prognostic relevance of cytokeratin 7 and 19 expression in hepatocellular carcinoma. A possible progenitor cell origin

2006 • 406 citations

Dysregulation of growth factor signaling in human hepatocellular carcinoma

2006 • 387 citations

Identification of local and circulating cancer stem cells in human liver cancer

2008 • 342 citations

Epithelial-to-Mesenchymal Transition and Integrin-Linked Kinase Mediate Sensitivity to Epidermal Growth Factor Receptor Inhibition in Human Hepatoma Cells

2008 • 307 citations

Phase 2 study of cetuximab in patients with advanced hepatocellular carcinoma

2007 • 247 citations

Laminin-5 With Transforming Growth Factor-β1 Induces Epithelial to Mesenchymal Transition in Hepatocellular Carcinoma

2005 • 243 citations

Circulating Tumor Cells and Bone Marrow Micrometastasis

2008 • 243 citations

Origin and characterization of a human bipotent liver progenitor cell line☆

2004 • 217 citations

A crucial function of PDGF in TGF-β-mediated cancer progression of hepatocytes

2006 • 205 citations

β-Catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development

2008 • 192 citations

Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-β1 and Ha-Ras: steps towards invasiveness

2002 • 184 citations

Wnt/β-catenin signaling mediates oval cell response in rodents

2007 • 171 citations

Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene

2008 • 168 citations

Immunoreactive e-cadherin, alpha-catenin,beta-catenin, and gamma-catenin proteins in hepatocellular carcinoma: Relationships with tumor grade, clinicopathologic parameters, and patients' survival

2000 • 167 citations

Stem cells, cell transplantation and liver repopulation

2007 • 166 citations

Hepatic tumor–stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge

2009 • 163 citations

Mammalian Target of Rapamycin Pathway Activity in Hepatocellular Carcinomas of Patients Undergoing Liver Transplantation

2007 • 150 citations

Wnt/frizzled signaling in hepatocellular carcinoma

2006 • 150 citations

PDGF essentially links TGF-β signaling to nuclear β-catenin accumulation in hepatocellular carcinoma progression

2006 • 137 citations

INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas

2001 • 132 citations

Signal Transducers and Activators of Transcription 5b Activation Enhances Hepatocellular Carcinoma Aggressiveness through Induction of Epithelial-Mesenchymal Transition

2006 • 116 citations

Up-regulation of Twist induces angiogenesis and correlates with metastasis in hepatocellular carcinoma.

2007 • 112 citations

Activated hepatic stellate cells induce tumor progression of neoplastic hepatocytes in a TGF‐β dependent fashion

2006 • 95 citations

ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression

2008 • 90 citations

Biology of transforming growth factor ? in hepatocarcinogenesis

2001 • 78 citations

Transforming growth factor-beta and cancer: a love-hate relationship?

1997 • 76 citations

Expression of β-catenin in hepatocellular carcinoma

2005 • 60 citations

Predictive Value of Biological Markers for Hepatocellular Carcinoma Patients Treated with Orthotopic Liver Transplantation

2004 • 52 citations

The evolution of liver transplantation for hepatocellular carcinoma (past, present, and future)

2008 • 47 citations

Transplantation for hepatocellular carcinoma: The Milan criteria and beyond

2006 • 46 citations

Integration of Ras subeffector signaling in TGF-β mediated late stage hepatocarcinogenesis

2005 • 45 citations

Outcomes and prognostic factors of cirrhotic patients with hepatocellular carcinoma after radical major hepatectomy

2007 • 44 citations

Immortalized p19ARF null hepatocytes restore liver injury and generate hepatic progenitors after transplantation

2004 • 35 citations

p14ARF gene alterations in human hepatocellular carcinoma

2004 • 22 citations