Oxidative Damage to Nucleic Acids in Human Prion Disease

Prions

1998 • 5,102 citations

Novel Proteinaceous Infectious Particles Cause Scrapie

1982 • 4,972 citations

Reactive Oxygen Species and the Central Nervous System

1992 • 2,931 citations

Diagnosis of Alzheimer's Disease

1985 • 2,482 citations

Mice devoid of PrP are resistant to scrapie

1993 • 2,058 citations

The cellular prion protein binds copper in vivo

1997 • 1,263 citations

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

1997 • 1,241 citations

Neurotoxicity of a prion protein fragment

1993 • 937 citations

Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

1995 • 835 citations

Prion protein is necessary for normal synaptic function

1994 • 802 citations

RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease

1999 • 718 citations

Normal prion protein has an activity like that of superoxide dismutase

1999 • 520 citations

Oxidative Stress in Huntington's Disease

1999 • 491 citations

Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene

1996 • 483 citations

Prion Protein-Deficient Cells Show Altered Response to Oxidative Stress Due to Decreased SOD-1 Activity

1997 • 447 citations

Oxidative Stress and Genetics in the Pathogenesis of Parkinson's Disease

2000 • 405 citations

Neuronal Oxidative Stress Precedes Amyloid-β Deposition in Down Syndrome

2000 • 321 citations

No propagation of prions in mice devoid of PrP

1994 • 282 citations

Oxidative Stress and Motor Neurone Disease

1999 • 220 citations

Prion Protein-Deficient Neurons Reveal Lower Glutathione Reductase Activity and Increased Susceptibility to Hydrogen Peroxide Toxicity

1999 • 191 citations

Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein

2001 • 171 citations

Normal prion protein has an activity like that of superoxide dismutase

1999 • 170 citations

Effects of Copper on Survival of Prion Protein Knockout Neurons and Glia

1998 • 159 citations

Evidence for Oxidative Stress in Experimental Prion Disease

2000 • 137 citations

Neuronal RNA Oxidation in Alzheimer's Disease and Down's Syndrome

1999 • 110 citations

Effects of oxidative stress on prion protein expression in pc12 cells

1997 • 107 citations

Differential Contribution of Superoxide Dismutase Activity by Prion Protein in Vivo

2000 • 107 citations

Oxidative Stress, Antioxidants, and Alzheimer Disease

2000 • 100 citations

Distribution of Parvalbumin-Immunoreactive Neurons in Brain Correlates with Hippocampal and Temporal Cortical Pathology in Creutzfeldt-Jakob Disease

1997 • 84 citations

Does hydrogen peroxide exist “free” in biological systems?

1991 • 84 citations

Marked increase of neuronal prion protein immunoreactivity in Alzheimer's disease and human prion diseases

2001 • 81 citations

Selective Neuronal Vulnerability in Human Prion Diseases

1999 • 71 citations

Prion Protein Glycosylation Is Sensitive to Redox Change

1999 • 67 citations

Induction of HO-1 and NOS in Doppel-Expressing Mice Devoid of PrP: Implications for Doppel Function

2001 • 64 citations

Oxidative damage and breakage of DNA in rat brain after transient MCA occlusion

1999 • 60 citations

Prion protein expression in mammalian lenses

2000 • 27 citations