Efficient Synthesis of Antisense Phosphorothioate Oligonucleotides: Evaluation of Dichloroacetic Acid at Higher Concentration to Reduce Cycle Time

Advances in the Synthesis of Oligonucleotides by the Phosphoramidite Approach

1992 • 688 citations

Nucleosides – nucleotides

1989 • 451 citations

Arylsulfonyltetrazoles, new coupling reagents and further improvements in the triester method for the synthesis of deoxyribooligonucleotides¹

1977 • 235 citations

Rapid and selective detritylation of primary alcohols using formic acid

1986 • 117 citations

The triphenylmethyl (trityl) group and its uses in nucleotide chemistry

1980 • 97 citations

Kinetic studies on depurination and detritylation of CPG-bound intermediates during oligonucleotide synthesis

1996 • 86 citations

Synthesis of High-Quality Antisense Drugs. Addition of Acrylonitrile to Phosphorothioate Oligonucleotides: Adduct Characterization and Avoidance

2003 • 75 citations

Detritylation of Ethers Using Iodine−Alcohol Reagents: An Acid-Catalyzed Reaction

1998 • 75 citations

The use of zinc bromide for removal of dimethoxytrityl ethers from deoxynucleosides

1980 • 73 citations

Quantitative capillary gel electrophoresis assay of phosphorothioate oligonucleotides in pharmaceutical formulations

1994 • 70 citations

Dialkyl aluminium chloride: a reagent for removal of trityl group from trityl ethers of deoxynucleosides, deoxynucleotides, and oligodeoxynucleotides

1982 • 59 citations

Selectivity of anion exchange chromatography and capillary gel electrophoresis for the analysis of phosphorothioate oligonucleotides

1997 • 52 citations

Synthesis of Antisense Oligonucleotides: Replacement of 3H-1,2-Benzodithiol-3-one 1,1-Dioxide (Beaucage Reagent) with Phenylacetyl Disulfide (PADS) As Efficient Sulfurization Reagent: From Bench to Bulk Manufacture of Active Pharmaceutical Ingredient

1999 • 50 citations

Selective N-deacylation of N,O-protected nucleosides by zinc bromide

1981 • 48 citations

On the Selective Deprotection of Trityl Ethers

1999 • 45 citations

Silica gel-catalyzed detritylation of some carbohydrate derivatives

1967 • 44 citations

Detritylation with ytterbium triflate

2000 • 35 citations

Acid binding and detritylation during oligonucleotide synthesis

1996 • 35 citations

A facile method for deprotection of trityl ethers using column chromatography

2001 • 33 citations

Deoxyribonucleosides and related compounds. Part IV. The configuration at the glycosidic centre in deoxyadenosine and deoxycytidine

1954 • 32 citations

1,1,1,3,3,3-Hexafluoro-2-propanol for the removal of the 4,4′-DimethoxytrityI protecting group from the 5′-hydroxyl of acid-sensitive nucleosides and nucleotides

1995 • 32 citations

Selective deprotection by reductive cleavage with radical anions

1975 • 29 citations

Synthesis of an antisense oligonucleotide targeted against C-raf kinase: efficient oligonucleotide synthesis without chlorinated solvents

1999 • 29 citations

Removal of Acetal, Silyl, and 4,4‘-Dimethoxytrityl Protecting Groups from Hydroxyl Functions of Carbohydrates and Nucleosides with Clay in Aqueous Methanol

1996 • 29 citations

Enthalpic Studies of Complex Formation between Carboxylic Acids and 1-Alkylimidazoles

1998 • 27 citations

New detritylation method for nucleosides and nucleotides by ceric ammonium nitrate

1996 • 27 citations

Large-Scale Synthesis of Oligodeoxyribonucleotide Phosphorothioate Using Controlled-Pore Glass as Support

1995 • 24 citations

A new method for the detritylation of alcohols bearing other reducible and acid-hydrolyzable functionalities.

1993 • 22 citations

Detritylation of carbohydrate derivatives with sodium in liquid ammonia

1972 • 21 citations

Rapid oligodeoxyribonucleotide synthesis by the “filtration” method

1984 • 21 citations

Large-Scale Synthesis of Antisense Oligonucleotides without Chlorinated Solvents

1999 • 21 citations

Biopharmaceutical process validation

2000 • 20 citations

Large‐Scale Economic Synthesis of Antisense Phosphorothioate Analogues of DNA for Preclinical Investigations

1990 • 20 citations

Selective Electrochemical Removal of Protecting Groups in Nucleotide Synthesis

1979 • 19 citations

Synthesis of antisense oligonucleotides

1999 • 16 citations

Antisense Phosphorothioate Oligodeoxyribonucleotide Targeted against ICAM-1: Use of I-Linker to Eliminate 3‘-Terminal Phosphorothioate Monoester Formation

2003 • 14 citations

A Facile Method for Detritylation of 5′-O-Dimethoxytrityl-3′-O-tert-butyldimethylsilyl-2′-deoxynucleosides

1994 • 14 citations

Facile selective detritylation of 5?-primary alcohols of pyrimidine nucleosides using tetra-n-butylammonium peroxydisulfate

1997 • 10 citations

NUCLEOSIDE 3′-PHOSPHOTRIESTERS AS KEY INTERMEDIATES FOR THE OLIGORIBONUCLEOTIDES SYNTHESIS VIA PHOSPHOTRIESTER APPROACH

1979 • 8 citations

A New Method for Removal of Modified Trityl and Pixyl Groups by Use of an Acid Species Generated by Reaction of Diethyl Oxomalonate with Methanol

1994 • 8 citations

A Mild and Efficient Detritylation of Some Carbohydrate Derivatives

1994 • 6 citations

International Roundtable Conference «Actual Problems of Macedonian and Slovenian Studies»

2022 • 1 citations