The Conserved Carboxyl Terminus and Zinc Finger-like Domain of the Co-chaperone Ydj1 Assist Hsp70 in Protein Folding

Molecular chaperones in cellular protein folding

1996 • 3,540 citations

Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding

1992 • 965 citations

Escherichia coli DnaJ and GrpE heat shock proteins jointly stimulate ATPase activity of DnaK.

1991 • 835 citations

DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70

1994 • 473 citations

The Role of ATP in the Functional Cycle of the DnaK Chaperone System

1995 • 388 citations

Interaction of hsp70 with unfolded proteins: effects of temperature and nucleotides on the kinetics of binding.

1991 • 332 citations

Regulation of the Heat-shock Protein 70 Reaction Cycle by the Mammalian DnaJ Homolog, Hsp40

1996 • 323 citations

A zinc finger-like domain of the molecular chaperone DnaJ is involved in binding to denatured protein substrates.

1996 • 304 citations

The NH2-terminal 108 amino acids of the Escherichia coli DnaJ protein stimulate the ATPase activity of DnaK and are sufficient for lambda replication.

1994 • 285 citations

YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism

1992 • 280 citations

The Role of Hsp70 in Conferring Unidirectionality on Protein Translocation into Mitochondria

1994 • 269 citations

Regulation of Hsp70 function by a eukaryotic DnaJ homolog.

1992 • 262 citations

The Protein Import System of Mitochondria

1996 • 261 citations

A Conserved HPD Sequence of the J-domain Is Necessary for YDJ1 Stimulation of Hsp70 ATPase Activity at a Site Distinct from Substrate Binding

1996 • 258 citations

The emergence of the chaperone machines

1992 • 249 citations

Topology and functional domains of Sec63p, an endoplasmic reticulum membrane protein required for secretory protein translocation.

1992 • 239 citations

Role of the Protein Chaperone YDJ1 in Establishing Hsp90-Mediated Signal Transduction Pathways

1995 • 237 citations

Molecular chaperones cooperate with PIM1 protease in the degradation of misfolded proteins in mitochondria.

1994 • 237 citations

Eukaryotic DnaJ homologs and the specificity of Hsp70 activity

1993 • 228 citations

Eukaryotic homologues of Escherichia coli dnaJ: a diverse protein family that functions with hsp70 stress proteins.

1993 • 225 citations

A Bipartite Signaling Mechanism Involved in DnaJ-mediated Activation of the Escherichia coli DnaK Protein

1996 • 222 citations

Involvement of the chaperonin dnaK in the rapid degradation of a mutant protein in Escherichia coli.

1992 • 199 citations

Monomerization of RepA dimers by heat shock proteins activates binding to DNA replication origin.

1991 • 183 citations

Reconstitution of protein translocation from solubilized yeast membranes reveals topologically distinct roles for BiP and cytosolic Hsc70.

1993 • 171 citations

Nuclear Magnetic Resonance Solution Structure of the Human Hsp40 (HDJ-1) J-domain

1996 • 155 citations

Involvement of the Molecular Chaperone Ydj1 in the Ubiquitin-Dependent Degradation of Short-Lived and Abnormal Proteins in Saccharomyces cerevisiae

1996 • 153 citations

A yeast DnaJ homologue, Scj1p, can function in the endoplasmic reticulum with BiP/Kar2p via a conserved domain that specifies interactions with Hsp70s.

1995 • 151 citations

Structure-Function Analysis of the Zinc Finger Region of the DnaJ Molecular Chaperone

1996 • 150 citations

NMR structure determination of the Escherichia coli DnaJ molecular chaperone: secondary structure and backbone fold of the N-terminal region (residues 2-108) containing the highly conserved J domain.

1994 • 147 citations

MAS5, a Yeast Homolog of DnaJ Involved in Mitochondrial Protein Import

1992 • 143 citations

The Cysteine String Secretory Vesicle Protein Activates Hsc70 ATPase

1996 • 138 citations

Hormone-dependent Transactivation by the Human Androgen Receptor Is Regulated by a dnaJ Protein

1995 • 137 citations

The Conserved G/F Motif of the DnaJ Chaperone Is Necessary for the Activation of the Substrate Binding Properties of the DnaK Chaperone

1995 • 128 citations

Activation of the ATPase activity of heat-shock proteins Hsc70/Hsp70 by cysteine-string protein

1997 • 127 citations

Cooperation of the molecular chaperone Ydj1 with specific Hsp70 homologs to suppress protein aggregation

1995 • 121 citations

Differential regulation of Hsp70 subfamilies by the eukaryotic DnaJ homologue YDJ1

1994 • 101 citations

Divergent Effects of ATP on the Binding of the DnaK and DnaJ Chaperones to Each Other, or to Their Various Native and Denatured Protein Substrates

1995 • 100 citations

The delta psi- and Hsp70/MIM44-dependent reaction cycle driving early steps of protein import into mitochondria.

1996 • 99 citations

Biogenesis of mitochondrial proteins

1996 • 81 citations

Conserved ATPase and luciferase refolding activities between bacteria and yeast Hsp70 chaperones and modulators

1995 • 72 citations

1H and 15N Magnetic Resonance Assignments, Secondary Structure, and Tertiary Fold of Escherichia coli DnaJ(1-78)

1995 • 67 citations

Auxilin-Induced Interaction of the Molecular Chaperone Hsc70 with Clathrin Baskets

1997 • 67 citations

The Ydj1 molecular chaperone facilitates formation of active p60v-src in yeast.

1996 • 66 citations

Interaction of Auxilin with the Molecular Chaperone, Hsc70

1997 • 60 citations

The Escherichia coli chaperones involved in DNA replicadon

1993 • 53 citations

Coupling chemical energy by the hsp70/tim44 complex to drive protein translocation into mitochondria.

1997 • 9 citations