Expression of granulocyte colony-stimulating factor– and granulocyte-macrophage colony-stimulating factor–associated signal transduction proteins of the JAK/STAT pathway in normal granulopoiesis and in blast cells of acute myelogenous leukemia

STATs and Gene Regulation

1997 • 3,927 citations

Epidermal growth factor-related peptides and their receptors in human malignancies

1995 • 2,689 citations

Recombinant Human Granulocyte Colony-Stimulating Factor: Effects on Normal and Leukemic Myeloid Cells

1986 • 1,260 citations

Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors

1998 • 1,155 citations

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

1996 • 915 citations

Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses

1998 • 827 citations

A TEL-JAK2 Fusion Protein with Constitutive Kinase Activity in Human Leukemia

1997 • 810 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

1992 • 661 citations

Signaling Through the Hematopoietic Cytokine Receptors

1995 • 617 citations

Fusion of TEL, the ETS-Variant Gene 6 (ETV6), to the Receptor-Associated Kinase JAK2 as a Result of t(9; 12) in a Lymphoid and t(9; 15; 12) in a Myeloid Leukemia

1997 • 494 citations

Mutations in the Gene for the Granulocyte Colony-Stimulating–Factor Receptor in Patients with Acute Myeloid Leukemia Preceded by Severe Congenital Neutropenia

1995 • 471 citations

Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects.

1995 • 460 citations

Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation.

1996 • 414 citations

STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription

1996 • 378 citations

Differential Regulation of the Alpha/Beta Interferon-Stimulated Jak/Stat Pathway by the SH2 Domain-Containing Tyrosine Phosphatase SHPTP1

1995 • 346 citations

STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line.

1996 • 345 citations

Form and Function in Protein Dephosphorylation

1996 • 334 citations

Interleukin-3 signals through multiple isoforms of Stat5.

1995 • 327 citations

STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients

1996 • 312 citations

Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: Tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines

1997 • 226 citations

Autonomous Proliferation of Leukemic Cells in Vitro as a Determinant of Prognosis in Adult Acute Myeloid Leukemia

1993 • 186 citations

Involvement of STAT3 in the Granulocyte Colony-stimulating Factor-induced Differentiation of Myeloid Cells

1997 • 183 citations

STAT5A-Deficient Mice Demonstrate a Defect in Granulocyte-Macrophage Colony-Stimulating Factor–Induced Proliferation and Gene Expression

1997 • 180 citations

Granulocyte-Macrophage Colony-stimulating Factor-activated Signaling Pathways in Human Neutrophils

1998 • 165 citations

Jak1 Plays an Essential Role for Receptor Phosphorylation and Stat Activation in Response to Granulocyte Colony-Stimulating Factor

1997 • 150 citations

JAK3: a novel JAK kinase associated with terminal differentiation of hematopoietic cells.

1994 • 145 citations

Functional Differences between Stat3α and Stat3β

1997 • 145 citations

Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2.

1994 • 136 citations

Granulocyte-Macrophage Colony-stimulating Factor Stimulates JAK2 Signaling Pathway and Rapidly Activates p93 , STAT1 p91, and STAT3 p92 in Polymorphonuclear Leukocytes

1996 • 133 citations

Granulocyte colony-stimulating factor activation of Stat3 alpha and Stat3 beta in immature normal and leukemic human myeloid cells

1996 • 130 citations

Stat1 Is Induced and Activated by All-Trans Retinoic Acid in Acute Promyelocytic Leukemia Cells

1997 • 120 citations

Granulocyte-macrophage colony-stimulating factor preferentially activates the 94-kD STAT5A and an 80-kD STAT5A isoform in human peripheral blood monocytes

1996 • 93 citations

Persistent Epstein‐Barr virus infection associated with monosomy 7 or chromosome 3 abnormality in childhood myeloproliferative disorders

1985 • 88 citations

Retinoic acid induces signal transducer and activator of transcription (STAT) 1, STAT2, and p48 expression in myeloid leukemia cells and enhances their responsiveness to interferons.

1997 • 77 citations

Granulocyte Colony-Stimulating Factor Receptor at Various Differentiation Stages of Normal and Leukemic Hematopoietic Cells

1997 • 57 citations

Increased G-CSF responsiveness of bone marrow cells from hematopoietic cell phosphatase deficient viable motheaten mice.

1997 • 52 citations

Effect of recombinant GM-CSF and recombinant G-CSF on colony formation of blast progenitors in acute myeloblastic leukemia.

1989 • 37 citations

Dissociation of the Jak kinase pathway from G-CSF receptor signaling in neutrophils.

1997 • 36 citations

JAK3: expression and mapping to chromosome 19p12-13.1.

1997 • 31 citations

STAT3 activation is a critical step in gp130 mediated-terminal differentiation and growth arrest of a myeloid cell line

2000 • 31 citations

Structure and expression of the GM-CSF receptor alpha and beta chain genes in human leukemia.

1993 • 16 citations

Blast cell proliferative activity and sensitivity to GM-CSF in vitro are associated with early response to TAD-9 induction therapy in acute myeloid leukemia.

1995 • 12 citations

Deleted Work

1955 • 0 citations